Alexandra Léary
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View article: 80 Composite score combining collagen density and spatial organization predicts immune checkpoint inhibitor resistance in mismatch repair-deficient endometrial cancer
80 Composite score combining collagen density and spatial organization predicts immune checkpoint inhibitor resistance in mismatch repair-deficient endometrial cancer Open
View article: The extracellular matrix dictates ovarian cancer cell migration in an in vivo-derived circulating environment
The extracellular matrix dictates ovarian cancer cell migration in an in vivo-derived circulating environment Open
Ovarian cancer (OC) disseminates via ascites and interaction with peritoneal extracellular matrix (ECM). To dissect the crosstalk between ECM and ascites in OC cell migration, we developed an ovarian tumor-on-chip integrating OC tumor sphe…
View article: Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): 10-year clinical outcomes and post-hoc analysis by molecular classification from a randomised phase 3 trial
Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): 10-year clinical outcomes and post-hoc analysis by molecular classification from a randomised phase 3 trial Open
View article: Maintenance olaparib after platinum-based chemotherapy for advanced/metastatic endometrial cancer: GINECO randomized phase IIb UTOLA trial
Maintenance olaparib after platinum-based chemotherapy for advanced/metastatic endometrial cancer: GINECO randomized phase IIb UTOLA trial Open
View article: Supplementary Table 8 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Supplementary Table 8 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
Individual AT83 mouse tumor volumes during EX-527 treatment.
View article: Supplementary Table 3 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Supplementary Table 3 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
list of primers used for qPCR on human (KGN, COV434) and mouse (AT29 cells) GCT cell lines
View article: Supplementary Table 1 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Supplementary Table 1 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
Bulk RNA-seq data with markers of granulosa cells
View article: Supplementary Figure 2 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Supplementary Figure 2 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
PCA analyses of RNA-seq
View article: Supplementary Table 7 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Supplementary Table 7 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
Nrf2 target genes and ferroptosis-related genes in the three cell lines.
View article: Supplementary Figure 1 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Supplementary Figure 1 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
study of SIRT1 expression
View article: Supplementary Table 6 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Supplementary Table 6 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
Genes of the MitoCarta3.0 database altered by EX-527 treatment in the three cell lines.
View article: Supplementary Table 2 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Supplementary Table 2 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
List of antibodies used for immunohistochemistry and Western blot
View article: Supplementary Table 5 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Supplementary Table 5 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
RNA-seq data showing DEGs in the three cell lines
View article: Data from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Data from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
Clinical management of patients with ovarian granulosa cell tumor (GCT) remains poor. Sirtuin-1 (SIRT1), a deacetylase enzyme involved in the regulation of tumor growth and metastasis, may represent a therapeutic target because of the avai…
View article: Supplementary Figure 4 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Supplementary Figure 4 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
RT-qPCR analyses of selected DEGs identified by RNA-seq
View article: Supplementary Table 4 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Supplementary Table 4 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
Total number of genes expressed and differential gene expression in AT29, COV434 and KGN cells
View article: Supplementary Figure 3 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Supplementary Figure 3 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways Open
Dot plots of GO-BP
View article: Primary Analysis of EPIK-O/ENGOT-ov61: Alpelisib Plus Olaparib Versus Chemotherapy in Platinum-Resistant or Platinum-Refractory High-Grade Serous Ovarian Cancer Without <i>BRCA</i> Mutation
Primary Analysis of EPIK-O/ENGOT-ov61: Alpelisib Plus Olaparib Versus Chemotherapy in Platinum-Resistant or Platinum-Refractory High-Grade Serous Ovarian Cancer Without <i>BRCA</i> Mutation Open
PURPOSE Patients with platinum-resistant/platinum-refractory high-grade serous ovarian cancer (HGSOC) without a BRCA mutation have poor prognosis and limited treatment options. We report efficacy and biomarker data from EPIK-O, which inves…
View article: Prognostic Value of a Joint K‐PD Model With Tumor Size Dynamics and CA‐125 Kinetics in Recurrent Ovarian Cancer Patients: BOLD Phase II GINECO Study
Prognostic Value of a Joint K‐PD Model With Tumor Size Dynamics and CA‐125 Kinetics in Recurrent Ovarian Cancer Patients: BOLD Phase II GINECO Study Open
In patients with recurrent advanced ovarian cancer, there is a need for companion tests to guide the development of innovative chemotherapy‐free treatments. The modeled longitudinal CA‐125 ELIMination rate constant K KELIM‐B was a major pr…
View article: Supplementary Data 1 from Clonal Evolution of <i>PPM1D</i> Mutations in the Spectrum of Myeloid Disorders
Supplementary Data 1 from Clonal Evolution of <i>PPM1D</i> Mutations in the Spectrum of Myeloid Disorders Open
Supplementary Figures
View article: Data from Clonal Evolution of <i>PPM1D</i> Mutations in the Spectrum of Myeloid Disorders
Data from Clonal Evolution of <i>PPM1D</i> Mutations in the Spectrum of Myeloid Disorders Open
Purpose:PPM1D, a central regulator of the DNA damage response, is commonly mutated in therapy-related clonal hematopoiesis, acute myeloid leukemia (AML), and myelodysplastic syndromes (MDS). PPM1D mutations have been shown to…
View article: Supplementary Data 1 from Clonal Evolution of <i>PPM1D</i> Mutations in the Spectrum of Myeloid Disorders
Supplementary Data 1 from Clonal Evolution of <i>PPM1D</i> Mutations in the Spectrum of Myeloid Disorders Open
Supplementary Tables
View article: Randomized study evaluating optimal dose, efficacy, and safety of E7386 plus lenvatinib versus treatment of physician’s choice in advanced/recurrent endometrial carcinoma previously treated with platinum-based chemotherapy and immune checkpoint inhibitors
Randomized study evaluating optimal dose, efficacy, and safety of E7386 plus lenvatinib versus treatment of physician’s choice in advanced/recurrent endometrial carcinoma previously treated with platinum-based chemotherapy and immune checkpoint inhibitors Open
The trial is registered at ClinicalTrials.gov, NCT04008797.
View article: Olaparib combined to metronomic cyclophosphamide and metformin in women with recurrent advanced/metastatic endometrial cancer: the ENDOLA phase I/II trial
Olaparib combined to metronomic cyclophosphamide and metformin in women with recurrent advanced/metastatic endometrial cancer: the ENDOLA phase I/II trial Open
View article: High-Temperature Stability of Co-Based Amorphous/Nanocomposite Alloys in Terms of Oxidation and Secondary Crystallization Behavior
High-Temperature Stability of Co-Based Amorphous/Nanocomposite Alloys in Terms of Oxidation and Secondary Crystallization Behavior Open
View article: Clinical and biological characteristics associated with of loss-of-heterozygosity in endometrial cancer
Clinical and biological characteristics associated with of loss-of-heterozygosity in endometrial cancer Open
In this large multiethnic cohort, 17% of EC exhibited high LOH and correlated with hormone-receptor-negative tumors and poorer survival rates. LOH may serve as a tool for identifying EC cases with high genomic instability that could potent…
View article: Patterns of genomic instability in > 2000 patients with ovarian cancer across six clinical trials evaluating olaparib
Patterns of genomic instability in > 2000 patients with ovarian cancer across six clinical trials evaluating olaparib Open
Background The introduction of poly(ADP-ribose) polymerase (PARP) inhibitors represented a paradigm shift in the treatment of ovarian cancer. Genomic data from patients with high-grade ovarian cancer in six phase II/III trials involving th…
View article: Prognostic value of circulating tumor DNA at diagnosis and its early decrease after one cycle of neoadjuvant chemotherapy for patients with advanced epithelial ovarian cancer. An ancillary analysis of the CHIVA phase II GINECO trial
Prognostic value of circulating tumor DNA at diagnosis and its early decrease after one cycle of neoadjuvant chemotherapy for patients with advanced epithelial ovarian cancer. An ancillary analysis of the CHIVA phase II GINECO trial Open
Early decrease of ctDNA ratio can provide prognostic information early in the management of patients, allowing a more accurate information to patients and an early preparation for CRS (prehabilitation).
View article: Consensus on drivers of maintenance treatment choice and patterns of care in advanced ovarian cancer
Consensus on drivers of maintenance treatment choice and patterns of care in advanced ovarian cancer Open
View article: Prediction of homologous recombination deficiency from routine histology with attention-based multiple instance learning in nine different tumor types
Prediction of homologous recombination deficiency from routine histology with attention-based multiple instance learning in nine different tumor types Open