Alexandra M. Harrington
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View article: Clinical, genetic, and pathologic differences across race, ethnicity, and sex in patients with MDS and precursor conditions from the national MDS natural history study
Clinical, genetic, and pathologic differences across race, ethnicity, and sex in patients with MDS and precursor conditions from the national MDS natural history study Open
Introduction Defining the epidemiology of myelodysplastic syndromes/neoplasms (MDS) and precursor conditions, such as clonal cytopenia of undetermined significance (CCUS), is challenging due to inconsistent reporting, complex diagnostics, …
View article: A Triple Threat: Acute Systemic Lupus Erythematosus Unveiled with Hemophagocytic Lymphohistiocytosis and Toxic Epidermal Necrolysis
A Triple Threat: Acute Systemic Lupus Erythematosus Unveiled with Hemophagocytic Lymphohistiocytosis and Toxic Epidermal Necrolysis Open
A 36-year-old man with a history of arthritis, initially diagnosed as seronegative rheumatoid arthritis, developed new-onset SLE complicated by HLH and TEN. The patient presented with fevers, abdominal pain, vomiting, fatigue, rash, and si…
View article: Outcome of Patients with TP53 Mutated Relapsed/Refractory AML with Lintuzumab-Ac225 in Combination with CLAG-M Following Venetoclax Plus Hypomethylating Agent Therapy
Outcome of Patients with TP53 Mutated Relapsed/Refractory AML with Lintuzumab-Ac225 in Combination with CLAG-M Following Venetoclax Plus Hypomethylating Agent Therapy Open
Background In acute myeloid leukemia (AML), guidelines support use of BCL2-inhibitor venetoclax (ven) and hypomethylating agents (HMAs) as frontline or salvage therapy, regardless of fitness, in patients with poor risk AML, such as TP53-mu…
View article: A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia
A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia Open
Azacitidine/venetoclax is an active regimen in patients with newly diagnosed AML. However, primary or secondary resistance to azacitidine/venetoclax is an area of unmet need and overexpression of MCL-1 is suggested to be a potential resist…
View article: Ileitis in Adult Multisystem Inflammatory Syndrome: A Case Report
Ileitis in Adult Multisystem Inflammatory Syndrome: A Case Report Open
Multisystem inflammatory syndrome (MIS) can manifest with nonspecific gastrointestinal symptoms, fever, shock, and cardiovascular dysfunction. Compared with children, MIS in adults (MIS-A) is rare. We present a definitive case of MIS-A (ba…
View article: Assessment of Molecular Residual Disease Using Circulating Tumor DNA to Identify Multiple Myeloma Patients at High Risk of Relapse
Assessment of Molecular Residual Disease Using Circulating Tumor DNA to Identify Multiple Myeloma Patients at High Risk of Relapse Open
Background Despite treatment with high-dose chemotherapy followed by autologous stem cell transplantation (AHCT), patients with multiple myeloma (MM) invariably relapse. Molecular residual disease (MRD)-negativity post-AHCT has emerged as …
View article: Comparison of the Institute for Credentialing Excellence Multi-Organization Survey of Certificants
Comparison of the Institute for Credentialing Excellence Multi-Organization Survey of Certificants Open
Introduction/Objective The Institute for Credentialing Excellence (ICE) conducted a study to measure the value that credential holders place on certification, collecting survey data from a large sample of more than 12,000 credential holder…
View article: Reducing IV-contaminated blood specimens in the clinical laboratory: A Quality Improvement Project
Reducing IV-contaminated blood specimens in the clinical laboratory: A Quality Improvement Project Open
Introduction/Objective Preanalytical errors constitute the most common errors in the laboratory, with improper specimen collection accounting for many errors. In our laboratory, we had a sentinel event related to repeated deletions of susp…
View article: The Pathologic Spectrum of Bone Marrow Involvement by Double- and Triple-hit Lymphomas
The Pathologic Spectrum of Bone Marrow Involvement by Double- and Triple-hit Lymphomas Open
Introduction/Objective B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements (double- and triple-hit lymphomas, DHL/THL) are a distinct entity due to shared biology and aggressive behavior, exhibiting poor outcomes with standard th…
View article: Ancillary Studies in the Diagnostic Evaluation of Large B-Cell Lymphoma
Ancillary Studies in the Diagnostic Evaluation of Large B-Cell Lymphoma Open
Context.— Large B-cell lymphoma classification has changed significantly over the decades, evolving from a purely morphologic categorization to one using sophisticated ancillary studies including molecular analysis, immunohistochemistry, a…
View article: Simple Laboratory Test Utilization Interventions to Reduce Inappropriate Specialty Coagulation Testing
Simple Laboratory Test Utilization Interventions to Reduce Inappropriate Specialty Coagulation Testing Open
Objectives The naming convention in coagulation may cause confusion in electronic ordering systems, leading to inappropriate test orders. We implemented test utilization efforts and studied utilization before and after interventions for tw…
View article: Factors that predict weight gain among first-year college students
Factors that predict weight gain among first-year college students Open
Aim and objectives: In the USA, undergraduate students gain more weight in the first year in college than at any other point in their lives. However, the factors that predict their weight gain are unknown. The purpose of this study was to …
View article: Carcinocythemia: A Rare Entity Becoming More Common? A 3-Year, Single-Institution Series of Seven Cases and Literature Review
Carcinocythemia: A Rare Entity Becoming More Common? A 3-Year, Single-Institution Series of Seven Cases and Literature Review Open
Carcinocythemia is a rare phenomenon defined as morphologically identifiable, circulating tumor cells (CTCs) in the peripheral blood. The presence of CTCs can cause diagnostic challenges for pathologists interpreting peripheral blood smear…
View article: Analysis of Physician-Requested Manual Differentials in Peripheral Blood Samples: An Institutional Study for Quality Improvement
Analysis of Physician-Requested Manual Differentials in Peripheral Blood Samples: An Institutional Study for Quality Improvement Open
In a recent audit of our orderables, we found a discrepancy between the Electronic Medical Record orderable “Manual Diff also order CBC” and the linked Laboratory Information System (LIS) translation “Physician requested manual smear revie…
View article: CD30 Expression in Monomorphic Posttransplant Lymphoproliferative Disorder, Diffuse Large B-Cell Lymphoma Correlates With Greater Regulatory T-Cell Infiltration
CD30 Expression in Monomorphic Posttransplant Lymphoproliferative Disorder, Diffuse Large B-Cell Lymphoma Correlates With Greater Regulatory T-Cell Infiltration Open
These findings suggest a pathophysiologic link between CD30 activity and Tregs and may indicate differential expression of CD30 in B-cell lymphomas arising in the setting of immune dysregulation.
View article: Extracavitary primary effusion lymphoma associated with hemophagocytic lymphohistiocytosis
Extracavitary primary effusion lymphoma associated with hemophagocytic lymphohistiocytosis Open
A 44-year-old African American male with history of human immunodeficiency virus (HIV) on antiretroviral therapy (ART), chronic hepatitis B, Kaposi sarcoma, and squamous cell cancer (SCC) of the anus was hospitalized with fevers and diarrh…
View article: Immunophenotypes of Chronic Myelomonocytic Leukemia (CMML) Subtypes by Flow Cytometry
Immunophenotypes of Chronic Myelomonocytic Leukemia (CMML) Subtypes by Flow Cytometry Open
These findings confirm heterogeneity within CMML subgroups and find no specific qualitative or quantitative findings characteristic of a subgroup.