A.G. Mitchell
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View article: Perceiving less or perceiving unreliably? Disentangling thermosensory sensitivity and precision in the contexts of ageing and neuropathy
Perceiving less or perceiving unreliably? Disentangling thermosensory sensitivity and precision in the contexts of ageing and neuropathy Open
Thermal perception is determined not only by sensitivity but also by precision, yet the latter is often overlooked in thermosensation and pain research. This study examined how ageing and diabetic polyneuropathy (DPN) affect the sensitivit…
View article: Modelling perceptual uncertainty in a thermosensory illusion across the lifespan
Modelling perceptual uncertainty in a thermosensory illusion across the lifespan Open
Most studies of perceptual illusions rely on explicit reports alone, offering a limited view into the computations that underlie ambiguous sensory experiences. Here, we introduce a multivariate computational approach to model paradoxical h…
View article: Thermosensory predictive coding underpins an illusion of pain
Thermosensory predictive coding underpins an illusion of pain Open
The human brain has a remarkable ability to learn and update its beliefs about the world. Here, we investigate how thermosensory learning shapes our subjective experience of temperature and the misperception of pain in response to harmless…
View article: Beyond bias: A registered examination of the validity of using line bisection to measure non-lateralised attention
Beyond bias: A registered examination of the validity of using line bisection to measure non-lateralised attention Open
Line bisection is a task widely used to assess lateral asymmetries of attention, in which participants are asked to mark the midpoint of a horizontal line. The directional bisection error (DBE) from the objective midpoint of the line is th…
View article: Gaze and attention: Mechanisms underlying the therapeutic effect of optokinetic stimulation in spatial neglect
Gaze and attention: Mechanisms underlying the therapeutic effect of optokinetic stimulation in spatial neglect Open
Left smooth pursuit eye movement training in response to large-field visual motion (optokinetic stimulation) has become a promising rehabilitation method in left spatial inattention or neglect. The mechanisms underlying the therapeutic eff…
View article: Uncertainty in Thermosensory Expectations Enhances an Illusion of Pain
Uncertainty in Thermosensory Expectations Enhances an Illusion of Pain Open
The human brain has a remarkable ability to learn and update its beliefs about the world. Here, we investigate how thermosensory learning shapes our subjective experience of temperature and the misperception of pain in response to harmless…
View article: Assessing Individual Sensitivity to the Thermal Grill Illusion: A Two-Dimensional Adaptive Psychophysical Approach
Assessing Individual Sensitivity to the Thermal Grill Illusion: A Two-Dimensional Adaptive Psychophysical Approach Open
In the thermal grill illusion (TGI), the spatial alternation of non-noxious warm and cold temperatures elicits burning sensations that resemble the presence of noxious stimuli. Previous research has largely relied on the use of specific te…
View article: Disentangling the spinal mechanisms of illusory heat and burning sensations in the Thermal Grill Illusion
Disentangling the spinal mechanisms of illusory heat and burning sensations in the Thermal Grill Illusion Open
The Thermal Grill Illusion (TGI), a phenomenon in which the juxtaposition of innocuous warm and cold temperatures on the skin elicits a burning sensation, offers a unique perspective to how pain occurs in response to harmless stimuli. We i…
View article: Thermal Contrast Enhancement Predicts Paradoxical Heat Sensation
Thermal Contrast Enhancement Predicts Paradoxical Heat Sensation Open
Paradoxical Heat Sensation (PHS) is the remarkable feeling of warmth or heat pain while the skin is cooling. Despite its initial documentation over 100 years ago, a unified explanation for this perplexing experience remains elusive. Here w…
View article: No short-term treatment effect of prism adaptation for spatial neglect: An inclusive meta-analysis
No short-term treatment effect of prism adaptation for spatial neglect: An inclusive meta-analysis Open
Despite 25 years of research on the topic, there is still no consensus on whether prism adaptation is an effective therapy for visuospatial neglect. We have addressed this question through a meta-analysis of the most well-controlled studie…
View article: A registered re-examination of the effects of leftward prism adaptation on landmark judgements in healthy people
A registered re-examination of the effects of leftward prism adaptation on landmark judgements in healthy people Open
It has long been known that active adaptation to a shift of the visual field, caused by laterally-displacing prisms, induces short-term sensorimotor aftereffects. More recent evidence suggests that prism adaptation may also stimulate highe…
View article: Cover Image
Cover Image Open
COVER ILLUSTRATION Proprioceptive coupling between the two eyes. A brief, passive stretch of the right eye's lateral rectus muscle in humans is associated with an increase in the BOLD response in the left oculomotor and abducens nuclei, wh…
View article: No Immediate Treatment Effect of Prism Adaptation for Spatial Neglect: An Inclusive Meta-analysis
No Immediate Treatment Effect of Prism Adaptation for Spatial Neglect: An Inclusive Meta-analysis Open
Despite nearly 25 years of research on the topic, there is still no consensus on whether prism adaptation is an effective therapy for visuospatial neglect. We present a meta-analysis from 1998 to 2021 on immediate treatment effects measure…
View article: Proprioceptive contribution to oculomotor control in humans
Proprioceptive contribution to oculomotor control in humans Open
Stretch receptors in the extraocular muscles (EOMs) inform the central nervous system about the rotation of one's own eyes in the orbits. Whereas fine control of the skeletal muscles hinges critically on proprioceptive feedback, the role o…
View article: On line bisection: Validity and reliability of online measures of pseudoneglect
On line bisection: Validity and reliability of online measures of pseudoneglect Open
This study assessed pseudoneglect using line bisection and perceptual landmark tasks in two matched online sessions. Line bisection bias was characterized by the traditional measure of Directional Bisection Error (DBE), and by Endpoint Wei…
View article: On line bisection: validity and reliability of online measures of pseudoneglect
On line bisection: validity and reliability of online measures of pseudoneglect Open
This study assessed pseudoneglect using line bisection and perceptual landmark tasks in two matched online sessions. Line bisection bias was characterised by the traditional measure of Directional Bisection Error (DBE), and by Endpoint Wei…
View article: Peripheral reaching in Alzheimer's disease and mild cognitive impairment
Peripheral reaching in Alzheimer's disease and mild cognitive impairment Open
Recent evidence has implicated areas within the posterior parietal cortex (PPC) as among the first to show pathophysiological changes in Alzheimer's disease (AD). Focal brain damage to the PPC can cause optic ataxia, a specific deficit in …
View article: Peripheral reaching in Alzheimer's disease and mild cognitive impairment
Peripheral reaching in Alzheimer's disease and mild cognitive impairment Open
Recent evidence has implicated areas within the posterior parietal cortex (PPC) as among the first to show pathophysiological changes in Alzheimer’s disease (AD). Focal brain damage to the PPC can cause optic ataxia, a specific deficit in …
View article: The reliability of pseudoneglect is task dependent
The reliability of pseudoneglect is task dependent Open
Bisection tasks that require individuals to identify the midpoint of a line are often used to assess the presence of biases to spatial attention in both healthy and patient populations. These tasks have helped to uncover a phenomenon calle…
View article: Assessment of visually guided reaching in prodromal Alzheimer’s disease: a cross-sectional study protocol
Assessment of visually guided reaching in prodromal Alzheimer’s disease: a cross-sectional study protocol Open
Introduction Recent evidence has implicated the precuneus of the medial parietal lobe as one of the first brain areas to show pathological changes in Alzheimer’s disease (AD). Damage to the precuneus through focal brain injury is associate…
View article: What drives bias? : an investigation into the anatomy of extra-oculomotor proprioception and its role in spatial neglect
What drives bias? : an investigation into the anatomy of extra-oculomotor proprioception and its role in spatial neglect Open
Spatial attention is used to selectively navigate to objects within our environment that are
\nsalient or deemed important. Successful allocation of attention in space requires a
\ncombination of positional, visual and spatial information …
View article: Bias in space and time: the reliability of pseudoneglect
Bias in space and time: the reliability of pseudoneglect Open
Pseudoneglect is the presence of a left-ward asymmetry in spatial cognition in neurotypical individuals (Bowers & Heilman, Neuropsychologia, 18(4):491, 1980). This effect is commonly demonstrated using bisection tasks that show participant…