Alexandra Moffat
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View article: <i>Etv5</i> Is Required for Peripheral Nerve Function and the Injury Response
<i>Etv5</i> Is Required for Peripheral Nerve Function and the Injury Response Open
The development of Schwann cells, which myelinate axons in the peripheral nervous system, is critically dependent on MEK/ERK signaling. While Ets-domain transcription factors ( Etv1 , Etv4 , Etv5 ) are downstream effectors of this pathway,…
View article: Neocortical neurogenesis: a proneural gene perspective
Neocortical neurogenesis: a proneural gene perspective Open
The neocortex, which is the site of higher‐order cognitive functioning, is comprised of two main neuronal types: excitatory (E) and inhibitory (I). Neurodevelopmental disorders that disrupt the balance of E:I neurotransmission predispose i…
View article: Examining the NEUROG2 lineage and associated gene expression in human cortical organoids
Examining the NEUROG2 lineage and associated gene expression in human cortical organoids Open
Proneural genes are conserved drivers of neurogenesis across the animal kingdom. How their functions have adapted to guide human-specific neurodevelopmental features is poorly understood. Here, we mined transcriptomic data from human fetal…
View article: <i>NEUROG2</i>regulates a human-specific neurodevelopmental gene regulatory program
<i>NEUROG2</i>regulates a human-specific neurodevelopmental gene regulatory program Open
Unique hallmarks of human neocortical development include slower rates of neurogenesis and the establishment of an extracellular matrix-rich, outer-subventricular zone that supports basal neural progenitor cell expansion. How gene regulato…
View article: The Control of Cortical Folding: Multiple Mechanisms, Multiple Models
The Control of Cortical Folding: Multiple Mechanisms, Multiple Models Open
The cerebral cortex develops through a carefully conscripted series of cellular and molecular events that culminate in the production of highly specialized neuronal and glial cells. During development, cortical neurons and glia acquire a p…
View article: Proneural genes form a combinatorial code to diversify neocortical neural progenitor cells
Proneural genes form a combinatorial code to diversify neocortical neural progenitor cells Open
Neocortical neural progenitor cells (NPCs) are molecularly heterogeneous, yet the genes that confer distinct neuronal morphologies and connectivities during development are poorly understood. Here, we determined that a proneural gene combi…
View article: Shifting attention does not influence numerical processing
Shifting attention does not influence numerical processing Open