Alexandra N. Nowbar
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View article: Therapeutic options for neurocardiogenic syncope: a meta-analysis of randomised trials with and without blinding
Therapeutic options for neurocardiogenic syncope: a meta-analysis of randomised trials with and without blinding Open
Background Neurocardiogenic syncope is a common condition with significant associated psychological and physical morbidity. The effectiveness of therapeutic options for neurocardiogenic syncope beyond placebo remains uncertain. Methods The…
View article: Why Does a Cardiologist Believe in a Therapy? The Role of Intuitiveness and Understanding the Mechanism
Why Does a Cardiologist Believe in a Therapy? The Role of Intuitiveness and Understanding the Mechanism Open
View article: A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina
A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina Open
Among patients with stable angina who were receiving little or no antianginal medication and had objective evidence of ischemia, PCI resulted in a lower angina symptom score than a placebo procedure, indicating a better health status with …
View article: Therapeutic options for syncope: a meta-analysis of trials with and without placebo control
Therapeutic options for syncope: a meta-analysis of trials with and without placebo control Open
Funding Acknowledgements Type of funding sources: None. Background 8% of the population suffer recurrent episodes of syncope which can cause physical injury and psychological morbidity. The extent to which therapeutic options effectively r…
View article: A randomized controlled trial to investigate the use of acute coronary syndrome therapy in patients hospitalized with COVID-19: the COVID-19 Acute Coronary Syndrome trial
A randomized controlled trial to investigate the use of acute coronary syndrome therapy in patients hospitalized with COVID-19: the COVID-19 Acute Coronary Syndrome trial Open
View article: Development of artificial intelligence tools for invasive Doppler-based coronary microvascular assessment
Development of artificial intelligence tools for invasive Doppler-based coronary microvascular assessment Open
Aims Coronary flow reserve (CFR) assessment has proven clinical utility, but Doppler-based methods are sensitive to noise and operator bias, limiting their clinical applicability. The objective of the study is to expand the adoption of inv…
View article: Cardiopulmonary exercise testing and efficacy of percutaneous coronary intervention: a substudy of the ORBITA trial
Cardiopulmonary exercise testing and efficacy of percutaneous coronary intervention: a substudy of the ORBITA trial Open
Aims Oxygen-pulse morphology and gas exchange analysis measured during cardiopulmonary exercise testing (CPET) has been associated with myocardial ischaemia. The aim of this analysis was to examine the relationship between CPET parameters,…
View article: Daily angina documentation versus subsequent recall: development of a symptom smartphone app
Daily angina documentation versus subsequent recall: development of a symptom smartphone app Open
Aims The traditional approach to documenting angina outcomes in clinical trials is to ask the patient to recall their symptoms at the end of a month. With the ubiquitous availability of smartphones and tablets, daily contemporaneous docume…
View article: Phasic flow patterns of right versus left coronary arteries in patients undergoing clinical physiological assessment
Phasic flow patterns of right versus left coronary arteries in patients undergoing clinical physiological assessment Open
In patients with coronary artery disease undergoing physiological assessment, diastolic flow predominance is seen in both left and right coronary arteries. Clinical interpretation of coronary physiological data should therefore not differ …
View article: Recruitment for placebo-controlled trials of interventional procedures: a patient-centred approach
Recruitment for placebo-controlled trials of interventional procedures: a patient-centred approach Open
View article: Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis
Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis Open
Aims This meta-analysis aims to quantify the association of reduced coronary flow with all-cause mortality and major adverse cardiovascular events (MACE) across a broad range of patient groups and pathologies. Methods and results We system…
View article: The Placebo-Controlled Effect of Percutaneous Coronary Intervention on Exercise Induced Changes in Anti-Malondialdehyde-LDL Antibody Levels in Stable Coronary Artery Disease: A Substudy of the ORBITA Trial
The Placebo-Controlled Effect of Percutaneous Coronary Intervention on Exercise Induced Changes in Anti-Malondialdehyde-LDL Antibody Levels in Stable Coronary Artery Disease: A Substudy of the ORBITA Trial Open
Aim: Malondialdehyde-modified low-density lipoprotein (MDA-LDL) forms a significant component of oxidised LDL. The effects of exercise on levels of MDA-LDL and anti-MDA-LDL antibodies are not well-understood. Furthermore, it is not known w…
View article: Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment
Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment Open
View article: Quality of Life Assessment in Trials of Revascularization for Chronic Stable Angina: Insights from ORBITA and the Implications of Blinding
Quality of Life Assessment in Trials of Revascularization for Chronic Stable Angina: Insights from ORBITA and the Implications of Blinding Open
The main aims of therapy in chronic stable angina are to reduce the risk of myocardial infarction and death and improve symptoms and quality of life (QoL). Unblinded trials have shown that revascularization does not reduce the risk of myoc…
View article: Placebo-Controlled Efficacy of Percutaneous Coronary Intervention for Focal and Diffuse Patterns of Stable Coronary Artery Disease
Placebo-Controlled Efficacy of Percutaneous Coronary Intervention for Focal and Diffuse Patterns of Stable Coronary Artery Disease Open
Background: Physiological assessment with pressure wire pullback can characterize coronary artery disease (CAD) with a focal or diffuse pattern. However, the clinical relevance of this distinction is unknown. We use data from the ORBITA tr…
View article: Controversies in revascularisation for stable coronary artery disease
Controversies in revascularisation for stable coronary artery disease Open
Recent randomised controlled trials, such as ISCHEMIA and ORBITA, have overturned most of what we were taught in medical school about hospital procedures considered necessary for patients with stable coronary artery disease. In this articl…
View article: Cost-effectiveness analysis of percutaneous coronary intervention for single-vessel coronary artery disease: an economic evaluation of the ORBITA trial
Cost-effectiveness analysis of percutaneous coronary intervention for single-vessel coronary artery disease: an economic evaluation of the ORBITA trial Open
Objective To evaluate the cost-effectiveness of percutaneous coronary intervention (PCI) compared with placebo in patients with single-vessel coronary artery disease and angina despite anti-anginal therapy. Design A cost-effectiveness anal…
View article: Achieving Optimal Medical Therapy: Insights From the ORBITA Trial
Achieving Optimal Medical Therapy: Insights From the ORBITA Trial Open
Background In stable coronary artery disease, medications are used for 2 purposes: cardiovascular risk reduction and symptom improvement. In clinical trials and clinical practice, medication use is often not optimal. The ORBITA (Objective …
View article: N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects
N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects Open
of N-of-1 trial of a statin, placebo, or no treatment to assess side effects.
View article: Gender-Related Differences in Clinical Presentation and Angiographic Findings in Patients with Ischemia and No Obstructive Coronary Artery Disease (INOCA): A Single-Center Observational Registry
Gender-Related Differences in Clinical Presentation and Angiographic Findings in Patients with Ischemia and No Obstructive Coronary Artery Disease (INOCA): A Single-Center Observational Registry Open
Ischemia and no obstructive coronary arteries (INOCA) is a common clinical presentation, with a variety of causes that are often not fully investigated in routine clinical practice. The goal of our study was to characterize a real-world po…
View article: Improving ultrasound video classification: an evaluation of novel deep learning methods in echocardiography
Improving ultrasound video classification: an evaluation of novel deep learning methods in echocardiography Open
Echocardiography is the commonest medical ultrasound examination, but automated interpretation is challenging and hinges on correct recognition of the 'view' (imaging plane and orientation). Current state-of-the-art methods for identifying…
View article: Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease
Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease Open
Background: In patients presenting with ST-segment–elevation myocardial infarction, percutaneous coronary intervention (PCI) reduces mortality when compared with fibrinolysis. In other forms of coronary artery disease (CAD), however, it ha…
View article: 483 Economic Evaluation of the ORBITA Trial, in the Australian Context
483 Economic Evaluation of the ORBITA Trial, in the Australian Context Open
View article: Fragility of the Bond Between Cardiovascular Investigators and Their Readers
Fragility of the Bond Between Cardiovascular Investigators and Their Readers Open
View article: Dobutamine Stress Echocardiography Ischemia as a Predictor of the Placebo-Controlled Efficacy of Percutaneous Coronary Intervention in Stable Coronary Artery Disease
Dobutamine Stress Echocardiography Ischemia as a Predictor of the Placebo-Controlled Efficacy of Percutaneous Coronary Intervention in Stable Coronary Artery Disease Open
Background: Dobutamine stress echocardiography is widely used to test for ischemia in patients with stable coronary artery disease. In this analysis, we studied the ability of the prerandomization stress echocardiography score to predict t…
View article: Mortality From Ischemic Heart Disease
Mortality From Ischemic Heart Disease Open
Background: Ischemic heart disease (IHD) has been considered the top cause of mortality globally. However, countries differ in their rates and there have been changes over time. Methods and Results: We analyzed mortality data submitted to …
View article: 112 Global and temporal trends in mortality from ischaemic heart disease: statistics from the World Health Organisation
112 Global and temporal trends in mortality from ischaemic heart disease: statistics from the World Health Organisation Open
Background Ischaemic heart disease (IHD) has been considered the top cause of mortality globally. However, countries differ in their rates and there have been changes over time. Methods We analysed mortality data submitted to the World Hea…
View article: Vascular Closure Devices for Transfemoral Angiography
Vascular Closure Devices for Transfemoral Angiography Open
View article: Safety profile and utility of treadmill exercise in patients with high-gradient hypertrophic cardiomyopathy
Safety profile and utility of treadmill exercise in patients with high-gradient hypertrophic cardiomyopathy Open
View article: 130 An Innovative Ambulatory Echocardiography Service Provides Rapid Access to Tests, Reduces Length of Hospital Stay and Improves Patient Care
130 An Innovative Ambulatory Echocardiography Service Provides Rapid Access to Tests, Reduces Length of Hospital Stay and Improves Patient Care Open
Introduction Demand for urgent Echocardiography in NHS Hospitals is increasing.1 Ambulatory care unit provides rapid access to investigations and improved quality of patient care in an outpatient setting. We recently introduced …