Alexandra Noble
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View article: The effect of delta-9 tetrahydrocannabinol and methamphetamine on sustained attention in the jumping spider (Trite planiceps).
The effect of delta-9 tetrahydrocannabinol and methamphetamine on sustained attention in the jumping spider (Trite planiceps). Open
Decreasing responsiveness to repeated visual stimuli (i.e., the inability to sustain attention) in jumping spiders (Salticidae) parallels that found in humans. In humans, drugs affect vigilance, and previous work on salticids has shown tha…
View article: Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III region
Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III region Open
Xue Li was supported by the Natural Science Fund for Distinguished Young Scholars of Zhejiang Province (LR22H260001) and the National Nature Science Foundation of China (No. 82204019). ET was supported by the CRUK Career Development Fellow…
View article: Peripheral blood DNA methylation signatures predict response to vedolizumab and ustekinumab in adult patients with Crohn’s disease: The EPIC-CD study
Peripheral blood DNA methylation signatures predict response to vedolizumab and ustekinumab in adult patients with Crohn’s disease: The EPIC-CD study Open
Biological therapeutics are now widely used in Crohn’s disease (CD), with evidence of efficacy from randomized trials and real-world experience. Primary non-response is a common, poorly understood problem. We assessed blood methylation as …
View article: Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease
Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease Open
View article: The impact of inversions across 33,924 families with rare disease from a national genome sequencing project
The impact of inversions across 33,924 families with rare disease from a national genome sequencing project Open
Detection of structural variants (SVs) is currently biased toward those that alter copy number. The relative contribution of inversions toward genetic disease is unclear. In this study, we analyzed genome sequencing data for 33,924 familie…
View article: Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease
Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease Open
View article: DOP55 High diagnostic accuracy of 4-probe methylation biomarkers in paediatric Inflammatory Bowel Disease by epigenome-wide analysis
DOP55 High diagnostic accuracy of 4-probe methylation biomarkers in paediatric Inflammatory Bowel Disease by epigenome-wide analysis Open
Background The application of -omics technology offers important opportunities for biomarker discovery to personalise management of patients with inflammatory bowel disease (IBD). In previous work, we reported a characteristic profile of g…
View article: Exposure to Air Pollution Increases Susceptibility to Ulcerative Colitis Through Epigenetic Alterations in CXCR2 and MHC Class III Region
Exposure to Air Pollution Increases Susceptibility to Ulcerative Colitis Through Epigenetic Alterations in CXCR2 and MHC Class III Region Open
View article: Defining Interactions Between the Genome, Epigenome, and the Environment in Inflammatory Bowel Disease: Progress and Prospects
Defining Interactions Between the Genome, Epigenome, and the Environment in Inflammatory Bowel Disease: Progress and Prospects Open
Recent advances in our understanding of the pathogenesis of inflammatory bowel disease (IBD) have highlighted the complex interplay between the genome, the epigenome, and the environment. Despite the exciting advances in genomics that have…
View article: Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC)
Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC) Open
View article: Source data for the project entitled "Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediate the effect of smoking on inflammatory bowel disease"
Source data for the project entitled "Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediate the effect of smoking on inflammatory bowel disease" Open
In this study, we aim first to assess the association between cigarette smoking and the risk of IBD through a prospective cohort study in the UK Biobank. Then, we evaluate the potential causal association between smoking behaviors and smok…
View article: A Final Frontier in Environment-Genome Interactions? Integrated, Multi-Omic Approaches to Predictions of Non-Communicable Disease Risk
A Final Frontier in Environment-Genome Interactions? Integrated, Multi-Omic Approaches to Predictions of Non-Communicable Disease Risk Open
Epidemiological and associative research from humans and animals identifies correlations between the environment and health impacts. The environment—health inter-relationship is effected through an individual’s underlying genetic variation…
View article: DNA methylation analysis using bisulphite-based amplicon sequencing of individuals exposed to maternal tobacco use during pregnancy, and offspring conduct problems in childhood and adolescence†
DNA methylation analysis using bisulphite-based amplicon sequencing of individuals exposed to maternal tobacco use during pregnancy, and offspring conduct problems in childhood and adolescence† Open
Maternal tobacco smoking during pregnancy is a large driver of health inequalities and a higher prevalence of conduct problem (CP) has been observed in exposed offspring. Further, maternal tobacco use during pregnancy can also alter offspr…
View article: Hypomethylation in<i>FASTKD1</i>detected in the association between<i>in utero</i>tobacco exposure and conduct problem in a New Zealand longitudinal study
Hypomethylation in<i>FASTKD1</i>detected in the association between<i>in utero</i>tobacco exposure and conduct problem in a New Zealand longitudinal study Open
Despite the known adverse effects of in utero tobacco exposure on offspring health, maternal tobacco use during pregnancy remains prevalent and is a major driver of health inequalities. One such health inequality is the development of cond…
View article: A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing
A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing Open
The Illumina Infinium ® MethylationEPIC BeadChip system (hereafter EPIC array) is considered to be the current gold standard detection method for assessing DNA methylation at the genome-wide level. EPIC arrays are often used for hypothesis…
View article: Peer Review #1 of "A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing (v0.1)"
Peer Review #1 of "A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing (v0.1)" Open
The Illumina Infinium® MethylationEPIC BeadChip system (hereafter EPIC array) is considered to be the current gold standard detection method for assessing DNA methylation at the genome-wide level.EPIC arrays areoften used for hypothesis ge…
View article: Peer Review #2 of "A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing (v0.1)"
Peer Review #2 of "A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing (v0.1)" Open
The Illumina Infinium® MethylationEPIC BeadChip system (hereafter EPIC array) is considered to be the current gold standard detection method for assessing DNA methylation at the genome-wide level.EPIC arrays areoften used for hypothesis ge…
View article: Peer Review #1 of "A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing (v0.2)"
Peer Review #1 of "A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing (v0.2)" Open
The Illumina Infinium® MethylationEPIC BeadChip system (hereafter EPIC array) is considered to be the current gold standard detection method for assessing DNA methylation at the genome-wide level.EPIC arrays areoften used for hypothesis ge…
View article: A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing
A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing Open
The Illumina Infinium® MethylationEPIC BeadChip system (hereafter EPIC array) is considered to be the current gold standard detection method for assessing DNA methylation at the genome-wide level. EPIC arrays are used for hypothesis genera…
View article: The impact of the environment on DNA methylation in humans and zebrafish
The impact of the environment on DNA methylation in humans and zebrafish Open
DNA methylation is a chemical modification to the DNA strand, which can control gene expression. DNA methylation can be modified by the environment. For example, tobacco use substantially alters DNA methylation, and hence DNA methylation t…