Alexandra Pincus
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View article: Distinct Metabolomic and Lipoprotein Signatures in Gall Bladder Cancer Patients of Black African Ancestry
Distinct Metabolomic and Lipoprotein Signatures in Gall Bladder Cancer Patients of Black African Ancestry Open
Background: Gall bladder cancer (GBC) is the most common biliary tract malignancy and is often diagnosed at advanced stages, partly due to the absence of reliable biomarkers and limited understanding of its biology in African populations. …
View article: Distinct Metabolomic and Lipoprotein Signatures in Gallbladder Cancer Patients of African Ancestry
Distinct Metabolomic and Lipoprotein Signatures in Gallbladder Cancer Patients of African Ancestry Open
Background Gall bladder cancer (GBC) is the most prevalent cancer of the biliary tract with a poor prognosis. Most of the patients are diagnosed at an advanced stage. This is due to a lack of reliable biomarkers and an understanding of the…
View article: Professional Title Use and Gender Representation During Grand Rounds and Invited Lectureships Across Specialties
Professional Title Use and Gender Representation During Grand Rounds and Invited Lectureships Across Specialties Open
Women remain underrepresented as grand rounds and invited speakers. Men and women were introduced by their professional title with similar frequency. Differences between departments suggested that introduction protocols increased title use…
View article: Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation
Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation Open
The appearance of misfolded and aggregated proteins is a pathological hallmark of numerous neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Sleep disruption is proposed to contribute to these pathological p…
View article: Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second-generation offspring
Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second-generation offspring Open
Asthma susceptibility is influenced by environmental, genetic, and epigenetic factors. This study shows that maternal allergen exposure during pregnancy promotes unique epigenetic trajectories in second-generation offspring at baseline and…
View article: Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring
Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring Open
SUPPLEMENTARY FIGURE LEGEND Supplemental Figure 1. Grandmaternal allergen exposure regulates differentially methylated cytosines in airway epithelium of second-generation offspring at baseline and after allergen se…
View article: Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring
Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring Open
SUPPLEMENTARY FIGURE LEGEND Supplemental Figure 1. Grandmaternal allergen sensitization during pregnancy regulates differentially methylated cytosines in airway epithelium of second-generation offspring at baseline…
View article: Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring
Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring Open
SUPPLEMENTARY FIGURE LEGEND Supplemental Figure 1. Grandmaternal allergen sensitization during pregnancy regulates differentially methylated cytosines in airway epithelium of second-generation offspring at baseline…
View article: Multicolor labeling of airway neurons and analysis of parasympathetic heterogeneity
Multicolor labeling of airway neurons and analysis of parasympathetic heterogeneity Open
We report subpopulations of airway parasympathetic neurons expressing substance P, neuronal nitric oxide synthase, and tyrosine hydroxylase, highlighting unexplored heterogeneity in this population. These neurotransmitter-specific subpopul…
View article: Grandmaternal allergen exposure causes distinct epigenetic trajectories in offspring associated with airway hyperreactivity and inflammation
Grandmaternal allergen exposure causes distinct epigenetic trajectories in offspring associated with airway hyperreactivity and inflammation Open
Maternal asthma increases childhood asthma risk through multiple mechanisms including epigenetic regulation of asthma-associated genes. DNA methylation is one form of epigenetic regulation that is both inherited and modified by environment…
View article: Airway Reactivity to Optogenetic Parasympathetic Nerve Stimulation Is Enhanced by Acute but Not Chronic Eosinophilia in Mice
Airway Reactivity to Optogenetic Parasympathetic Nerve Stimulation Is Enhanced by Acute but Not Chronic Eosinophilia in Mice Open
Rationale: Airway parasympathetic nerves provide the dominant control of airway tone.To study airway parasympathetic nerve-mediated bronchoconstriction in vivo, we developed an optogenetic mouse strain that expresses channelrhodopsin 2 dri…
View article: Maternal Allergen Exposure Causes Fetal Epigenetic Modification That Increases Allergen Responsiveness in Future Generations
Maternal Allergen Exposure Causes Fetal Epigenetic Modification That Increases Allergen Responsiveness in Future Generations Open
View article: Mini review: Neural mechanisms underlying airway hyperresponsiveness
Mini review: Neural mechanisms underlying airway hyperresponsiveness Open
View article: Live predator stress in adolescence results in distinct adult behavioral consequences and dorsal diencephalic brain activation patterns
Live predator stress in adolescence results in distinct adult behavioral consequences and dorsal diencephalic brain activation patterns Open
View article: Optogenetic Control of Airway Cholinergic Neurons<i>In Vivo</i>
Optogenetic Control of Airway Cholinergic Neurons<i>In Vivo</i> Open
Dysregulation of airway nerves leads to airway hyperreactivity, a hallmark of asthma. Although changes to nerve density and phenotype have been described in asthma, the relevance of these changes to nerve function has not been investigated…
View article: Eosinophil and airway nerve interactions in asthma
Eosinophil and airway nerve interactions in asthma Open
Airway eosinophils are increased in asthma and are especially abundant around airway nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways contract excessively to inhaled stimuli) develops when eosi…
View article: Droplet Interface Bilayers on a Petri Dish - Formation Methods and Characterization
Droplet Interface Bilayers on a Petri Dish - Formation Methods and Characterization Open