Alexandra Seger
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View article: Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma
Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma Open
Relapse and treatment resistance are common in children with high-risk neuroblastoma, and novel therapies are needed. Conventional drug discovery is slow, expensive, often fails in practice, and consequently falls short in addressing pedia…
View article: Targeted ferroptosis induction enhances chemotherapy efficacy in chemoresistant neuroblastoma
Targeted ferroptosis induction enhances chemotherapy efficacy in chemoresistant neuroblastoma Open
Neuroblastoma (NB) is an aggressive pediatric solid tumor which often develops chemoresistance. Ferroptosis is a potential vulnerability in NB, but its interplay with chemoresistance and standard-of-care chemotherapy is not known. Here, we…
View article: Evaluation of TRPA1 as a Therapeutic Target in <i>MYCN</i>‐Amplified Neuroblastoma
Evaluation of TRPA1 as a Therapeutic Target in <i>MYCN</i>‐Amplified Neuroblastoma Open
Background Neuroblastoma (NB) is a childhood cancer with a high relapse rate despite intensive treatment. TRPA1 is a pain‐sensing ion channel with downstream impacts on proliferative and pro‐apoptotic pathways. Here, we evaluated TRPA1 exp…
View article: Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma
Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma Open
Relapse and treatment resistance are common in children with high-risk neuroblastoma, and novel therapies are needed. Conventional drug discovery is slow, expensive, often fails in practice, and consequently falls short in addressing pedia…
View article: Patient-derived models: Advanced tools for precision medicine in neuroblastoma
Patient-derived models: Advanced tools for precision medicine in neuroblastoma Open
Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. High-risk neuroblastoma patients have a poor overall survival and account for ~15% of childhood cancer deaths. There is thus a need for clinically relevant an…
View article: Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance
Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance Open
Chemotherapy resistance and relapses are common in high-risk neuroblastoma (NB). Here, we developed a clinically relevant in vivo treatment protocol mimicking the first-line five-chemotherapy treatment regimen of high-risk NB and applied t…
View article: Clinically-relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance
Clinically-relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance Open
Chemotherapy resistance and relapses are common in high-risk neuroblastoma (NB), an aggressive pediatric solid tumor of the sympathetic nervous system. Here, we developed a clinically-relevant in vivo treatment protocol mimicking the first…