Alexandre Bory
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View article: Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery
Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery Open
Natural products remain vital to drug discovery, with fungi representing an underexplored source of bioactive compounds. Despite advances in LC-MS-based metabolomics that facilitate dereplication and chemical profiling of natural extracts,…
View article: Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates
Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates Open
Antibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from nat…
View article: A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data
A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data Open
MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can s…
View article: A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data
A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data Open
MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can s…
View article: Bioactivity of Spongian Diterpenoid Scaffolds from the Antarctic Sponge Dendrilla antarctica
Bioactivity of Spongian Diterpenoid Scaffolds from the Antarctic Sponge Dendrilla antarctica Open
The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary …
View article: <scp>WRINKLED</scp>1 and <scp>ACYL‐COA:DIACYLGLYCEROL ACYLTRANSFERASE</scp>1 regulate tocochromanol metabolism in Arabidopsis
<span>WRINKLED</span>1 and <span>ACYL‐COA:DIACYLGLYCEROL ACYLTRANSFERASE</span>1 regulate tocochromanol metabolism in Arabidopsis Open
Summary Photosynthetic organisms such as plants, algae and some cyanobacteria synthesize tocochromanols, a group of compounds that encompasses tocopherols and tocotrienols and that exhibits vitamin E activity in animals. While most vitamin…