Alexandre Destère
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View article: Safety profile of belatacept in a real-life setting: disproportionality analysis of the WHO pharmacovigilance database
Safety profile of belatacept in a real-life setting: disproportionality analysis of the WHO pharmacovigilance database Open
View article: Maximum cold ischemia duration for a kidney allograft: a prediction model for allograft failure at the time of organ allocation
Maximum cold ischemia duration for a kidney allograft: a prediction model for allograft failure at the time of organ allocation Open
View article: Evaluating and leveraging large language models in clinical pharmacology and therapeutics assessment: From exam takers to exam shapers
Evaluating and leveraging large language models in clinical pharmacology and therapeutics assessment: From exam takers to exam shapers Open
Aims In medical education, the ability of large language models (LLMs) to match human performance raises questions about their potential as educational tools. This study evaluates LLMs' performance on Clinical Pharmacology and Therapeutics…
View article: Artificial intelligence to guide rituximab therapy in patients with phospholipase A2 receptor–associated membranous nephropathy
Artificial intelligence to guide rituximab therapy in patients with phospholipase A2 receptor–associated membranous nephropathy Open
International audience
View article: Artificial intelligence-based personalised rituximab treatment protocol in membranous nephropathy (iRITUX): protocol for a multicentre randomised control trial
Artificial intelligence-based personalised rituximab treatment protocol in membranous nephropathy (iRITUX): protocol for a multicentre randomised control trial Open
Introduction Membranous nephropathy is an autoimmune kidney disease and the most common cause of nephrotic syndrome in non-diabetic Caucasian adults. Rituximab is now recommended as first-line therapy for membranous nephropathy. However, K…
View article: Apports des données en vie réelle à la sécurité des antipsychotiques chez l’enfant et l’adolescent
Apports des données en vie réelle à la sécurité des antipsychotiques chez l’enfant et l’adolescent Open
View article: PDL1 inhibitors may be associated with a lower risk of allograft rejection than PD1 and CTLA4 inhibitors: analysis of the WHO pharmacovigilance database
PDL1 inhibitors may be associated with a lower risk of allograft rejection than PD1 and CTLA4 inhibitors: analysis of the WHO pharmacovigilance database Open
Background Transplant recipients face increased cancer mortality due to immunosuppressive treatments. Immune checkpoint inhibitors (ICI) have improved survival rates, but data on the use of these agents in transplant recipients is scarce. …
View article: Maximum Cold Ischemia Duration for a Kidney Allograft a Prediction Model for Allograft Failure at the Time of Organ Allocation
Maximum Cold Ischemia Duration for a Kidney Allograft a Prediction Model for Allograft Failure at the Time of Organ Allocation Open
View article: Couple and Sexuality vs. Smartphone: Who Wins? Impact of Smartphone Addiction on Marital and Sexual Satisfaction in Couples
Couple and Sexuality vs. Smartphone: Who Wins? Impact of Smartphone Addiction on Marital and Sexual Satisfaction in Couples Open
View article: To be or not to be, when synthetic data meet clinical pharmacology: A focused study on pharmacogenetics
To be or not to be, when synthetic data meet clinical pharmacology: A focused study on pharmacogenetics Open
The use of synthetic data in pharmacology research has gained significant attention due to its potential to address privacy concerns and promote open science. In this study, we implemented and compared three synthetic data generation metho…
View article: A case of lenacapavir use for preventing mother-to-child HIV transmission
A case of lenacapavir use for preventing mother-to-child HIV transmission Open
International audience
View article: Deep dynamic co-clustering of count data streams: application to pharmacovigilance
Deep dynamic co-clustering of count data streams: application to pharmacovigilance Open
Co-clustering is a widely used technique that allows the analysis of complex and high-dimensional data in various domains. However, existing models mostly concentrate on continuous and dense data in fixed time situations, where cluster ass…
View article: A Plasma Pyrophosphate Cutoff Value for Diagnosing Pseudoxanthoma Elasticum
A Plasma Pyrophosphate Cutoff Value for Diagnosing Pseudoxanthoma Elasticum Open
Pseudoxanthoma elasticum (PXE) is a rare inherited systemic disease responsible for a juvenile peripheral arterial calcification disease. The clinical diagnosis of PXE is only based on a complex multi-organ phenotypic score and/or genetica…
View article: A machine learning approach to predict daptomycin exposure from two concentrations based on Monte Carlo simulations
A machine learning approach to predict daptomycin exposure from two concentrations based on Monte Carlo simulations Open
Daptomycin is a concentration-dependent lipopeptide antibiotic for which exposure/effect relationships have been shown. Machine learning (ML) algorithms, developed to predict the individual exposure to drugs, have shown very good performan…
View article: Optimization of Ganciclovir and Valganciclovir Starting Dose in Children by Machine Learning
Optimization of Ganciclovir and Valganciclovir Starting Dose in Children by Machine Learning Open
View article: Cardiac and metabolic safety profile of antipsychotics in youths: A WHO safety database analysis
Cardiac and metabolic safety profile of antipsychotics in youths: A WHO safety database analysis Open
View article: Optimization of Rituximab Therapy in Adult Patients With PLA2R1-Associated Membranous Nephropathy With Artificial Intelligence
Optimization of Rituximab Therapy in Adult Patients With PLA2R1-Associated Membranous Nephropathy With Artificial Intelligence Open
This algorithm could allow for early intensification of rituximab regimen in patients at high estimated risk of underdosing to increase the likelihood of remission.
View article: Tacrolimus population pharmacokinetics in adult heart transplant patients
Tacrolimus population pharmacokinetics in adult heart transplant patients Open
Introduction Tacrolimus is an immunosuppressant largely used in heart transplantation. However, the calculation of its exposure based on the area under the curve (AUC) requires the use of a population pharmacokinetic (PK) model. The aims o…
View article: The Neuropsychiatric Safety Profile of Lasmiditan: A Comparative Disproportionality Analysis with Triptans
The Neuropsychiatric Safety Profile of Lasmiditan: A Comparative Disproportionality Analysis with Triptans Open
View article: CAR-T Cells and the Kidney: Insights from the WHO Safety Database
CAR-T Cells and the Kidney: Insights from the WHO Safety Database Open
This study is limited by the inherent flaws of pharmacovigilance approaches. Nonetheless, our findings suggest that ARF and an array of hydroelectrolytic disorders are potential ADRs of CAR-T cell therapy, in real-life settings and in a no…
View article: Safety Signal Generation for Sudden Sensorineural Hearing Loss Following Messenger RNA COVID-19 Vaccination: Postmarketing Surveillance Using the French Pharmacovigilance Spontaneous Reporting Database
Safety Signal Generation for Sudden Sensorineural Hearing Loss Following Messenger RNA COVID-19 Vaccination: Postmarketing Surveillance Using the French Pharmacovigilance Spontaneous Reporting Database Open
Background The World Health Organization recently described sudden sensorineural hearing loss (SSNHL) as a possible adverse effect of COVID-19 vaccines. Recent discordant pharmacoepidemiologic studies invite robust clinical investigations …
View article: A Hybrid Algorithm Combining Population Pharmacokinetic and Machine Learning for Isavuconazole Exposure Prediction
A Hybrid Algorithm Combining Population Pharmacokinetic and Machine Learning for Isavuconazole Exposure Prediction Open
View article: A Hplc-Dad Method Facilitates Large-Scale Monitoring of Dalbavancin
A Hplc-Dad Method Facilitates Large-Scale Monitoring of Dalbavancin Open
View article: Safety Signal Generation for Sudden Sensorineural Hearing Loss Following Messenger RNA COVID-19 Vaccination: Postmarketing Surveillance Using the French Pharmacovigilance Spontaneous Reporting Database (Preprint)
Safety Signal Generation for Sudden Sensorineural Hearing Loss Following Messenger RNA COVID-19 Vaccination: Postmarketing Surveillance Using the French Pharmacovigilance Spontaneous Reporting Database (Preprint) Open
BACKGROUND The World Health Organization recently described sudden sensorineural hearing loss (SSNHL) as a possible adverse effect of COVID-19 vaccines. Recent discordant pharmacoepidemiologic studies invite robust clinical investigations…
View article: Monitoring of renal transplant patients treated with tacrolimus using population pharmacokinetics and machine learning
Monitoring of renal transplant patients treated with tacrolimus using population pharmacokinetics and machine learning Open
Le tacrolimus, pierre angulaire de la thérapie immunosuppressive dans la transplantation d’organe solide, possède un intervalle thérapeutique étroit ainsi qu’une variabilité interindividuelle importante exposant rapidement le patient à un …
View article: Antipsychotic Abuse, Dependence, and Withdrawal in the Pediatric Population: A Real-World Disproportionality Analysis
Antipsychotic Abuse, Dependence, and Withdrawal in the Pediatric Population: A Real-World Disproportionality Analysis Open
Antipsychotic drugs (APs) aim to treat schizophrenia, bipolar mania, and behavioral symptoms. In child psychiatry, despite limited evidence regarding their efficacy and safety, APs are increasingly subject to off-label use. Studies investi…
View article: Iohexol plasma and urinary concentrations in cirrhotic patients: A pilot study
Iohexol plasma and urinary concentrations in cirrhotic patients: A pilot study Open
Plasma clearance of iohexol seems useful for determining GFR regardless of the ascites grade. We will secondly devise a pharmacokinetics model requiring fewer samples andvalidate the BM equation.
View article: Drug-Associated Parosmia: New Perspectives from the WHO Safety Database
Drug-Associated Parosmia: New Perspectives from the WHO Safety Database Open
Parosmia is a qualitative distortion of smell perception. Resulting from central causes, sinonasal diseases, and infections, parosmia has also been associated with medications. Therefore, we aimed to investigate potential signals for drugs…
View article: Optimization of Vancomycin Initial Dose in Term and Preterm Neonates by Machine Learning
Optimization of Vancomycin Initial Dose in Term and Preterm Neonates by Machine Learning Open
View article: Medications as a Trigger of Sleep-Related Eating Disorder: A Disproportionality Analysis
Medications as a Trigger of Sleep-Related Eating Disorder: A Disproportionality Analysis Open
Sleep-related eating disorder (SRED) is a parasomnia with recurrent, involuntary, amnestic eating episodes during sleep. There is growing evidence of the association between SRED and medications. Therefore, we aimed to rank drugs showing t…