Alexandre Faille
YOU?
Author Swipe
View article: A 3.3-Å cryo-EM structure of an engineered high-affinity human prothrombinase complex
A 3.3-Å cryo-EM structure of an engineered high-affinity human prothrombinase complex Open
Thrombin is generated from prothrombin through cleavage at two sites by the enzyme prothrombinase, composed of factor (f) Xa and fVa. The affinity of fXa for fVa is low, with assembly and function dependent on phospholipid (PL) membranes. …
View article: Serious issues with cryo-EM structures of human prothrombinase
Serious issues with cryo-EM structures of human prothrombinase Open
Thrombin is generated from prothrombin through sequential cleavage at two sites by the enzyme complex prothrombinase, composed of a serine protease, factor (f) Xa and a cofactor, fVa, on phospholipid membranes. In a recent paper published …
View article: Catalytic Cycle of Type II 4′-Phosphopantetheinyl Transferases
Catalytic Cycle of Type II 4′-Phosphopantetheinyl Transferases Open
International audience
View article: Serious Issues with Cryo-EM Structures of Human Prothrombinase
Serious Issues with Cryo-EM Structures of Human Prothrombinase Open
Thrombin is generated from prothrombin through sequential cleavage at two sites by the enzyme complex prothrombinase, composed of a serine protease, factor (f) Xa, and a cofactor, fVa, on phospholipid membranes. The strict order of cleavag…
View article: The chemical landscape of the human ribosome at 1.67 Å resolution
The chemical landscape of the human ribosome at 1.67 Å resolution Open
The ability of ribosomes to translate the genetic code into protein requires a finely tuned ion and solvent ecosystem. However, the lack of high-resolution structures has precluded accurate positioning of all the functional elements of the…
View article: Teaching old drugs new tricks
Teaching old drugs new tricks Open
Understanding the mechanism by which streptomycin binds to the small subunit of the mitoribosome may help researchers design less toxic derivatives of this antibiotic.
View article: Publisher Correction: Somatic genetic rescue of a germline ribosome assembly defect
Publisher Correction: Somatic genetic rescue of a germline ribosome assembly defect Open
View article: Direct targeted therapy for MLL‐fusion‐driven high‐risk acute leukaemias
Direct targeted therapy for MLL‐fusion‐driven high‐risk acute leukaemias Open
Background Improving the poor prognosis of infant leukaemias remains an unmet clinical need. This disease is a prototypical fusion oncoprotein‐driven paediatric cancer, with MLL ( KMT2A )‐fusions present in most cases. Direct targeting of …
View article: eIF6 rebinding dynamically couples ribosome maturation and translation
eIF6 rebinding dynamically couples ribosome maturation and translation Open
Protein synthesis is a cyclical process consisting of translation initiation, elongation, termination and ribosome recycling. The release factors SBDS and EFL1—both mutated in the leukemia predisposition disorder Shwachman-Diamond syndrome…
View article: eIF6 rebinding dynamically couples ribosome maturation and translation
eIF6 rebinding dynamically couples ribosome maturation and translation Open
Protein synthesis is a cyclical process consisting of translation initiation, elongation, termination and ribosome recycling. The release factors SBDS and EFL1 (both mutated in the leukaemia predisposition disorder Shwachman-Diamond syndro…
View article: Somatic genetic rescue of a germline ribosome assembly defect
Somatic genetic rescue of a germline ribosome assembly defect Open
View article: Hemocyte siRNA uptake is increased by 5′ cholesterol-TEG addition in <i>Biomphalaria glabrata</i>, snail vector of schistosome
Hemocyte siRNA uptake is increased by 5′ cholesterol-TEG addition in <i>Biomphalaria glabrata</i>, snail vector of schistosome Open
Biomphalaria glabrata is one of the snail intermediate hosts of Schistosoma mansoni , the causative agent of intestinal schistosomiasis disease. Numerous molecular studies using comparative approaches between susceptible and resistant snai…
View article: Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases
Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases Open
Mycobacterium tuberculosis is the causative agent of the tuberculosis disease, which claims more human lives each year than any other bacterial pathogen. M. tuberculosis and other mycobacterial pathogens have developed a rang…
View article: Molecular basis for extender unit specificity of mycobacterial polyketide synthases
Molecular basis for extender unit specificity of mycobacterial polyketide synthases Open
View article: EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome
EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome Open
Shwachman-Diamond syndrome (SDS) is a recessive disorder typified by bone marrow failure and predisposition to hematological malignancies. SDS is predominantly caused by deficiency of the allosteric regulator Shwachman-Bodian-Diamond syndr…
View article: Mechanism of completion of peptidyltransferase centre assembly in eukaryotes
Mechanism of completion of peptidyltransferase centre assembly in eukaryotes Open
During their final maturation in the cytoplasm, pre-60S ribosomal particles are converted to translation-competent large ribosomal subunits. Here, we present the mechanism of peptidyltransferase centre (PTC) completion that explains how in…
View article: Author response: Mechanism of completion of peptidyltransferase centre assembly in eukaryotes
Author response: Mechanism of completion of peptidyltransferase centre assembly in eukaryotes Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract During their final maturation…
View article: Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B
Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B Open
ISRIB mechanism of action In rodents, a druglike small molecule named ISRIB enhances cognition and reverses cognitive deficits after traumatic brain injury. ISRIB activates a protein complex called eIF2B that is required for the synthesis …
View article: Binding of the integrated stress response inhibitor, ISRIB, reveals a regulatory site in the nucleotide exchange factor, elF2B
Binding of the integrated stress response inhibitor, ISRIB, reveals a regulatory site in the nucleotide exchange factor, elF2B Open
The Integrated Stress Response (ISR) is a conserved eukaryotic translational and transcriptional program implicated in mammalian metabolism, memory and immunity. The ISR is mediated by stress-induced phosphorylation of translation initiati…
View article: Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases
Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases Open