Explanipedia

Optimizing Dose Conversion from IR-Tac to LCP-Tac Formulations in Renal Transplant Recipients: A Population Pharmacokinetic Modeling Study Open

Zeyar Mohammed Ali, Beatriz Fernández-Alarcón, Pere Fontova, Anna Vidal‐Alabró, Raúl Rigo‐Bonnin , et al. · 2025

Background/Objectives: Tacrolimus dosing remains challenging due to its narrow therapeutic index and high inter- and intra-patient variability. The extended-release once-daily tacrolimus (LCP-Tac) formulation provides enhanced bioavailabil…

Optimizing Dose Conversion From IR-Tac to LCP-Tac Formulations in Renal Transplant Recipients: A Population Pharmacokinetic Modeling Study Open

Zeyar Mohammed Ali, Beatriz Fernández-Alarcón, Pere Fontova, Anna Vidal‐Alabró, Raúl Rigo‐Bonnin , et al. · 2025

Background/Objectives: The extended-release once-daily tacrolimus (LCP-Tac) formulation demonstrates enhanced bioavailability and a sustained pharmacokinetic profile compared to the immediate-release twice-daily tacrolimus (IR-Tac) formula…

ABS0077 MOLECULARLY DIVERSE PR3+ CELLS CHARACTERIZE LUPUS NEPHRITIS: A SPATIALLY RESOLVED MULTI-OMICS APPROACH Open

Alessandra Ida Celia, Chin‐Yun Lee, Taiwen Li, Eugene Shenderov, Kelly Casella , et al. · 2025

Role of SARS-CoV-2-specific memory B cells promoting immune protection after booster vaccination in solid organ transplantation Open

Laura Donadeu, Susana Gómez‐Ollés, Franc Casanova, Alba Torija, Manuel López‐Meseguer , et al. · 2024

Introduction Solid organ transplant (SOT) recipients display weak seroconversion and neutralizing antibody (NAb) responses after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and remain at risk of severe coronavi…

Corrigendum: Impaired antigen-specific B-cell responses after Influenza vaccination in kidney transplant recipients receiving co-stimulation blockade with Belatacept Open

Vincent Pernin, María Meneghini, Alba Torija, Thomas Jouvé, Arnaud Del Bello , et al. · 2024

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#1742 Hybrid-immunity protection against SARS-CoV-2 reinfection on kidney transplant recipients Open

Carlos Couceiro, Alexandre Favà, Laura Calatayud Semper, Núria Montero, Ana Coloma , et al. · 2024

Background and Aims Scarce data is available about the impact of hybrid immunity (vaccination plus infection) in immunocompromised patients. Several studies report a greater immunological response in hybrid individuals compared to those wh…

Hybrid Immunity Protection Against SARS-CoV-2 and Severe COVID-19 in Kidney Transplantation: A Retrospective, Comparative Cohort Study Open

Alexandre Favà, Carlos Monteagudo, Laura Calatayud, Yolanda Hernández-Hermida, Edoardo Melilli , et al. · 2024

#5672 CORTICAL IRON DEPOSITION ASSESSED BY MAGNETIC RESONANCE IMAGE IS ASSOCIATED WITH KIDNEY FIBROSIS Open

Carlos Couceiro, Sergi Codina, Diego Sandoval, Laia Oliveras, Isabel Puig , et al. · 2023

Background and Aims Fibrosis is responsible for the loss of kidney function as a result of several insults, such as ischemia-reperfusion injury or hyperfiltration. This process can continue even after cessation of the primary insult, as do…

POS0288 DEGRANULATING PR3+ MYELOID CELLS CHARACTERIZE PROLIFERATIVE LUPUS NEPHRITIS Open

Alessandra Ida Celia, Xiaoping Yang, Michelle Petri, Avi Z. Rosenberg, Alexandre Favà · 2023

POS1476 AUTOANTIBODY TRAJECTORIES ASSOCIATE WITH CLASSIFICATION AND TREATMENT RESPONSE IN LUPUS NEPHRITIS Open

Alexandre Favà, Carla J. Guthridge, John N. Kheir, Carrie Wagner, Michelle Petri , et al. · 2023

#4045 IMMUNOSUPPRESSION AND POST-TRANSPLANT HYPERGLYCEMIA Open

Laia Oliveras, Ana Coloma, Luis Lino, Alexandre Favà, Anna Manonelles , et al. · 2023

Background and Aims Post-transplant diabetes mellitus (PTDM) is a frequent complication after kidney transplantation (KT), with an incidence between 20-30%. PTDM increases the risk of cardiovascular disease, which is one of the main causes…

POS0297 PROTEOMIC ANALYSIS OF HISTOLOGICAL LESIONS LUPUS NEPHRITIS IDENTIFIES AN INFLAMMATORY SIGNATURE OF FIBROUS CRESCENTS Open

Alessandra Ida Celia, Jeffrey B. Hodgin, Dawit Demeke, Avi Z. Rosenberg, Laurence S. Magder , et al. · 2023

POS0289 SERUM SOLUBLE MEDIATOR SIGNATURES OF LUPUS NEPHRITIS HISTOLOGICAL FEATURES AND RESPONSE TO TREATMENT Open

Alexandre Favà, Carla J. Guthridge, John N. Kheir, Carrie Wagner, Michelle Petri , et al. · 2023

Herramientas para un ajuste de dosis de tacrolimus más personalizado en el seguimiento de los pacientes con transplante renal. Fenotipo metabolizador según polimorfismos genéticos del CYP3A vs. el cociente concentración-dosis Open

Anna Vidal‐Alabró, Helena Colom, Pere Fontova, Gema Cerezo, Edoardo Melilli , et al. · 2022

Resumen: Antecedentes y justificación: La estrategia de la aproximación concentración-dosis (C/D) y los distintos perfiles del tacrolimus (Tac), según los polimorfismos del citocromo P450 (CYPs) se centran en el metabolismo de Tac y se pla…

Delayed initiation or reduced initial dose of calcineurin-inhibitors for kidney transplant recipients Open

Laia Oliveras, Pamela Lopez‐Vargas, Edoardo Melilli, Sergi Codina, Ana Royuela , et al. · 2022

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: This review aims to look at the benefits and harms of delayed initiation of CNI or reduced initial CNI dose as initial immunosuppression therapy for KT…

Sex differences in COVID-19 mortality risk in patients on kidney function replacement therapy Open

Priya Vart, Raphaël Duivenvoorden, Aaltje Y Adema, Adrian Covic, Patrik Finne , et al. · 2022

The Clinical Frailty Scale as a triage tool for ICU admission of dialysis patients with COVID-19: an ERACODA analysis Open

Pim Bouwmans, Lloyd Brandts, Luuk B. Hilbrands, Raphaël Duivenvoorden, Priya Vart , et al. · 2022

Background Several guidelines recommend using the Clinical Frailty Scale (CFS) for triage of critically ill coronavirus disease 2019 (COVID-19) patients. This study evaluates the impact of CFS on intensive care unit (ICU) admission rate an…

Impaired antigen-specific B-cell responses after Influenza vaccination in kidney transplant recipients receiving co-stimulation blockade with Belatacept Open

Vincent Pernin, María Meneghini, Alba Torija, Thomas Jouvé, Arnaud Del Bello , et al. · 2022

Emerging data suggest that costimulation blockade with belatacept effectively controls humoral alloimmune responses. However, whether this effect may be deleterious for protective anti-infectious immunity remains poorly understood. We perf…

Collapsing Glomerulonephritis in a Kidney Transplant Recipient after mRNA SARS-CoV-2 Vaccination Open

Francisco Gómez Preciado, Rosa Alejandra De Carvalho Ovalles, Sergi Codina, Laura Donadeu, Alexandre Favà , et al. · 2022

With the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies are describing cases of glomerulonephritis arising after vaccination. We present the first case of a kidney transplant patient who, after mR…

Effect of kidney replacement therapy modality after first kidney graft failure on second kidney transplantation outcomes Open

Carlos Couceiro, Inés Rama, Jordi Comas, Núria Montero, Anna Manonelles , et al. · 2022

Background There is a lack of information regarding which is the best dialysis technique after kidney transplant (KT) failure. The aim of this study is to compare the effect of kidney replacement therapy modality-peritoneal dialysis (TX-PD…

Risk Factors and Outcomes of Acute Graft Pyelonephritis with Bacteremia Due to Multidrug-Resistant Gram-Negative Bacilli among Kidney Transplant Recipients Open

Núria Sabé, M. Maristany-Bosch, Manel Tuells, Alexandre Favà, Edoardo Melilli , et al. · 2022

Acute graft pyelonephritis (AGP) is the leading cause of bloodstream infection in kidney transplant (KT) recipients. The prevalence of urinary tract infections caused by multidrug-resistant (MDR) Gram-negative bacilli is increasing. This 1…

Page Kidney In Kidney Transplantation: A Case Series Open

Raül Sánchez-Marin, Núria Montero, Edoardo Melilli, Ana Coloma, Alexandre Favà , et al. · 2022

A 70-year-old male with hypertension, ischemic cardiac diseaseand with a chronic kidney disease due to membranous nephropathy, received a KT from a controlled cardiac death donor. He received as a induction therapy basiliximab.

Association of obesity with 3-month mortality in kidney failure patients with COVID-19 Open

Ekamol Tantisattamo, Céline Imhof, Kitty J. Jager, Luuk B. Hilbrands, Rebecca Guidotti , et al. · 2022

Background In the general population with coronavirus disease 2019 (COVID-19), obesity is associated with an increased risk of mortality. Given the typically observed obesity paradox among patients on kidney function replacement therapy (K…

A comprehensive assessment of long-term SARS-CoV-2–specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients Open

Alexandre Favà, Laura Donadeu, Thomas Jouvé, José González‐Costello, Laura Lladó , et al. · 2022

Recovery of dialysis patients with COVID-19: health outcomes 3 months after diagnosis in ERACODA Open

Marc H. Hemmelder, Marlies Noordzij, Priya Vart, Luuk B. Hilbrands, Kitty J. Jager , et al. · 2022

Background Coronavirus disease 2019 (COVID-19)-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery in a large cohort of dialysis patients 3 months …

COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study Open

Éric Goffin, Alexandre Candellier, Priya Vart, Marlies Noordzij, Miha Arnol , et al. · 2021

Background Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and kidney transplant (KT) recipients to an unprecedented life-threatening infectious disease, raising concerns about kidney replacement therapy (KRT) s…

Clinical triage of patients on kidney replacement therapy presenting with COVID-19: an ERACODA registry analysis Open

Sandip Mitra, Anuradha Jayanti, Priya Vart, Armando Coca, Maurizio Gallieni , et al. · 2021

Background Patients on kidney replacement therapy (KRT) are at very high risk of coronavirus disease 2019 (COVID-19). The triage pathway for KRT patients presenting to hospitals with varying severity of COVID-19 illness remains ill-defined…

MO993IMMUNOSUPPRESSION MINIMIZATION IN KIDNEY TRANSPLANT RECIPIENTS HOSPITALIZED FOR COVID-19 Open

Paula Antón Pampols, Hernando Trujillo, Edoardo Melilli, Blanca Urban, Justo Sandino , et al. · 2021

Background and Aims Immunosuppressed patients such as kidney transplant recipients (KTs) have increased mortality risk in the setting of coronavirus disease 2019 (COVID-19). The role and management of chronic immunosuppressive therapies du…

SARS-CoV-2-specific serological and functional T cell immune responses during acute and early COVID-19 convalescence in solid organ transplant patients Open

Alexandre Favà, Laura Donadeu, Núria Sabé, Vincent Pernin, José González‐Costello , et al. · 2021

Donor/Recipient HLA Molecular Mismatch Scores Predict Primary Humoral and Cellular Alloimmunity in Kidney Transplantation Open

María Meneghini, Elena Crespo, Matthias Niemann, Alba Torija, Núria Lloberas , et al. · 2021

Donor/recipient molecular human leukocyte antigen (HLA) mismatch predicts primary B-cell alloimmune activation, yet the impact on de novo donor-specific T-cell alloimmunity (dnDST) remains undetermined. The hypothesis of our study is that …

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