Explanipedia

STRAF 2: New features and improvements of the STR population data analysis software Open

Alexandre Gouy, Martin Zieger · 2024

Population data in forensic genetics must be checked for a variety of statistical parameters before it can be employed for casework. Several tools exist to perform such tasks; however, it can become challenging to obtain the right results …

Genomes of <i>Microtus</i> Rodents Highlight the Importance of Olfactory and Immune Systems in Their Fast Radiation Open

Alexandre Gouy, Xuejing Wang, Adamandia Kapopoulou, Samuel Neuenschwander, Emanuel Schmid , et al. · 2024

The characterization of genes and biological functions underlying functional diversification and the formation of species is a major goal of evolutionary biology. In this study, we investigated the fast radiation of Microtus voles, one of …

A holistic approach for the selection of forensic DNA swabs Open

David Comment, Alexandre Gouy, Christian Zingg, Martin Zieger · 2023

In the present study, we compared the performance of five different ISO 18385 certified forensic swabs for DNA sampling in practice over a time period of five months. Comparisons were made for DNA profiling success rates, measured as the p…

Human background DNA on stones in an urban environment Open

Aileen Sorg, Alexandre Gouy, Colin Charles Tièche, Martin Zieger · 2023

Stones are frequently used as tools in criminal acts. In our department, around 5 % of all analysed crime scene related trace samples are contact or touch DNA traces swabbed from stones. These samples are primarily related to cases of dama…

Population genetic analysis of 12 X-chromosomal STRs in a Swiss sample Open

Michel Bottinelli, Alexandre Gouy, Silvia Utz, Martin Zieger · 2021

X-chromosomal STRs are a powerful tool to assess a broad variety of complex kinship scenarios. We introduce herewith the first Swiss X-STR dataset based on 1198 individuals (592 female, 606 male), characterized with the Qiagen Investigator…

<i>fastsimcoal2</i>: demographic inference under complex evolutionary scenarios Open

Laurent Excoffier, Nina Marchi, David A. Marques, Remi Matthey‐Doret, Alexandre Gouy , et al. · 2021

Motivation fastsimcoal2 extends fastsimcoal, a continuous time coalescent-based genetic simulation program, by enabling the estimation of demographic parameters under very complex scenarios from the site frequency spectrum under a maximum-…

Expanding the Swiss autosomal marker set to 32 STRs Open

Martin Zieger, Alexandre Gouy, Silvia Utz · 2021

By genotyping 1198 individuals with the Qiagen Investigator® HDplex Kit, we expand the Swiss autosomal STR dataset to 32 loci, providing additional resources for complex kinship cases. We present the first high-quality allele frequency dat…

Recent Evolutionary History of Tigers Highlights Contrasting Roles of Genetic Drift and Selection Open

Ellie E. Armstrong, Anubhab Khan, Ryan W. Taylor, Alexandre Gouy, Gili Greenbaum , et al. · 2021

Species conservation can be improved by knowledge of evolutionary and genetic history. Tigers are among the most charismatic of endangered species and garner significant conservation attention. However, their evolutionary history and genom…

Polygenic Patterns of Adaptive Introgression in Modern Humans Are Mainly Shaped by Response to Pathogens Open

Alexandre Gouy, Laurent Excoffier · 2019

Anatomically modern humans carry many introgressed variants from other hominins in their genomes. Some of them affect their phenotype and can thus be negatively or positively selected. Several individual genes have been proposed to be the …

Polygenic patterns of adaptive introgression in modern humans are mainly shaped by response to pathogens Open

Alexandre Gouy, Laurent Excoffier · 2019

Anatomically modern humans carry many introgressed variants from other hominins in their genomes. Some of them affect their phenotype and can thus be negatively or positively selected. Several individual genes have been proposed to be the …

Recent evolutionary history of tigers highlights contrasting roles of genetic drift and selection Open

Ellie E. Armstrong, Anubhab Khan, Ryan W. Taylor, Alexandre Gouy, Gili Greenbaum , et al. · 2019

Formulating strategies for species conservation requires knowledge of evolutionary and genetic history. Tigers are among the most charismatic of endangered species and garner significant conservation attention. However, the evolutionary hi…

Relaxed Selection During a Recent Human Expansion Open

Stephan Peischl, Isabelle Dupanloup, Adrien Foucal, Michèle Jomphe, Vanessa Bruat , et al. · 2017

Peischl et al. explore the way evolutionary forces shape genetic variability in expanding human populations. Over a few generations of separate evolution... Humans have colonized the planet through a series of range expansions, which deepl…

Detecting gene subnetworks under selection in biological pathways Open

Alexandre Gouy, Joséphine T. Daub, Laurent Excoffier · 2017

Advances in high throughput sequencing technologies have created a gap between data production and functional data analysis. Indeed, phenotypes result from interactions between numerous genes, but traditional methods treat loci independent…

Detecting gene subnetworks under selection in biological pathways Open

Alexandre Gouy, Joséphine T. Daub, Laurent Excoffier · 2017

Advances in high throughput sequencing technologies have created a gap between data production and functional data analysis. Indeed, phenotypes result from interactions between numerous genes, but traditional methods treat loci independent…

Relaxed selection during a recent human expansion Open

Stephan Peischl, Isabelle Dupanloup, Adrien Foucal, Michèle Jomphe, Vanessa Bruat , et al. · 2016

Humans have colonized the planet through a series of range expansions, which deeply impacted genetic diversity in newly settled areas and potentially increased the frequency of deleterious mutations on expanding wave fronts. To test this p…

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