Alexandre Leytens
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View article: Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy
Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy Open
Macroautophagy/autophagy is a constitutively active catabolic lysosomal degradation pathway, often found dysregulated in human diseases. It is often considered to act in a cytoprotective manner and is commonly upregulated in cells undergoi…
View article: An APEX2-based proximity-dependent biotinylation assay with temporal specificity to study protein interactions during autophagy in the yeast <i>Saccharomyces cerevisiae</i>
An APEX2-based proximity-dependent biotinylation assay with temporal specificity to study protein interactions during autophagy in the yeast <i>Saccharomyces cerevisiae</i> Open
Autophagosome biogenesis is a complex process orchestrated by dynamic interactions between Atg (autophagy-related) proteins and characterized by the turnover of specific cargoes, which can differ over time and depending on how autophagy is…
View article: Dipeptidyl Peptidase-4–Mediated Fibronectin Processing Evokes a Profibrotic Extracellular Matrix
Dipeptidyl Peptidase-4–Mediated Fibronectin Processing Evokes a Profibrotic Extracellular Matrix Open
View article: Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy
Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy Open
Autophagy is a constitutively active catabolic lysosomal degradation pathway, often found dysregulated in human diseases. It is often considered to act in a cytoprotective manner and is commonly upregulated in cells undergoing stress. Its …
View article: The dynamin Vps1 mediates Atg9 transport to the sites of autophagosome formation
The dynamin Vps1 mediates Atg9 transport to the sites of autophagosome formation Open
View article: The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress
The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress Open
Tumours face tryptophan (Trp) depletion, but the mechanisms sustaining protein biosynthesis under Trp stress remain unclear. We report that Trp stress increases the levels of the translation repressor EIF4EBP1. Yet, at the same time, EIF4E…
View article: DRAMing for autophagy
DRAMing for autophagy Open
Autophagy, a catabolic lysosomal recycling pathway, is often found dysregulated in human diseases. Whereas its prime cell stress‐related function is cytoprotection, autophagy has also been linked to the activation of apoptosis and cell dea…
View article: ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy
ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy Open