Alexandre Lüscher
YOU?
Author Swipe
View article: Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery
Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery Open
Natural products remain vital to drug discovery, with fungi representing an underexplored source of bioactive compounds. Despite advances in LC-MS-based metabolomics that facilitate dereplication and chemical profiling of natural extracts,…
View article: Phenylalkyl Acetophenones and Anacardic Acids from Knema oblongifolia with Synthetic Analogues as Anti-infectives and Antibacterial Agents
Phenylalkyl Acetophenones and Anacardic Acids from Knema oblongifolia with Synthetic Analogues as Anti-infectives and Antibacterial Agents Open
The present study investigates the potential anti-infective and antibacterial properties of phenylalkyl acetophenones and anacardic acids isolated from the ethyl acetate extract of the leaves of Knema oblongifolia, along with synthetic der…
View article: Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates
Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates Open
Antibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from nat…
View article: Antimicrobial Peptide–Peptoid Hybrids with and without Membrane Disruption
Antimicrobial Peptide–Peptoid Hybrids with and without Membrane Disruption Open
Among synthetic analogues of antimicrobial peptides (AMPs) under investigation to address antimicrobial resistance, peptoids (N-alkylated oligoglycines) have been reported to act both by membrane disruption and on intracellular targets. He…
View article: Personalized aerosolised bacteriophage treatment of a chronic lung infection due to multidrug-resistant Pseudomonas aeruginosa
Personalized aerosolised bacteriophage treatment of a chronic lung infection due to multidrug-resistant Pseudomonas aeruginosa Open
Bacteriophage therapy has been suggested as an alternative or complementary strategy for the treatment of multidrug resistant (MDR) bacterial infections. Here, we report the favourable clinical evolution of a 41-year-old male patient with …
View article: Personalized aerosolised bacteriophage treatment of a chronic lung infection due to multidrug-resistant Pseudomonas aeruginosa
Personalized aerosolised bacteriophage treatment of a chronic lung infection due to multidrug-resistant Pseudomonas aeruginosa Open
Bacteriophage therapy has been suggested as an alternative or complementary strategy for the treatment of multidrug resistant (MDR) bacterial infections. Here, we report the favourable clinical evolution of a 41-year-old male patient with …
View article: Personalized aerosolised bacteriophage treatment of a chronic lung infection due to multidrug-resistant Pseudomonas aeruginosa
Personalized aerosolised bacteriophage treatment of a chronic lung infection due to multidrug-resistant Pseudomonas aeruginosa Open
Bacteriophage therapy has been suggested as an alternative or complementary strategy for the treatment of multidrug resistant (MDR) bacterial infections. Here, we report the favourable clinical evolution of a 41-year-old male patient with …
View article: Targeting HuR-Vav3 mRNA interaction prevents Pseudomonas aeruginosa adhesion to the cystic fibrosis airway epithelium
Targeting HuR-Vav3 mRNA interaction prevents Pseudomonas aeruginosa adhesion to the cystic fibrosis airway epithelium Open
Cystic fibrosis (CF) is characterized by chronic bacterial infections leading to progressive bronchiectasis and respiratory failure. Pseudomonas aeruginosa (Pa) is the predominant opportunistic pathogen infecting the CF airways. The guanin…
View article: Plant-Derived Catechols Are Substrates of TonB-Dependent Transporters and Sensitize Pseudomonas aeruginosa to Siderophore-Drug Conjugates
Plant-Derived Catechols Are Substrates of TonB-Dependent Transporters and Sensitize Pseudomonas aeruginosa to Siderophore-Drug Conjugates Open
Iron is an essential element for living organisms. Most bacteria synthesize species-specific iron chelators, called siderophores, able to capture iron from their host or the environment. Pseudomonas aeruginosa , an opportunistic pathogen, …
View article: Plant-derived catechols are substrates of TonB-dependent transporters and sensitize Pseudomonas aeruginosa to siderophore-drug conjugates
Plant-derived catechols are substrates of TonB-dependent transporters and sensitize Pseudomonas aeruginosa to siderophore-drug conjugates Open
The dataset contains raw data used to generate the figures of the associated mansucript
View article: Plant-derived catechols are substrates of TonB-dependent transporters and sensitize Pseudomonas aeruginosa to siderophore-drug conjugates
Plant-derived catechols are substrates of TonB-dependent transporters and sensitize Pseudomonas aeruginosa to siderophore-drug conjugates Open
The dataset contains raw data used to generate the figures of the associated mansucript
View article: Chiral Separation of Stilbene Dimers Generated by Biotransformation for Absolute Configuration Determination and Antibacterial Evaluation
Chiral Separation of Stilbene Dimers Generated by Biotransformation for Absolute Configuration Determination and Antibacterial Evaluation Open
A series of complex stilbene dimers have been generated through biotransformation of resveratrol, pterostilbene, and the mixture of both using the enzymatic secretome of Botrytis cinerea Pers. The process starts with achiral molecules and …
View article: Surface Hydration Protects Cystic Fibrosis Airways from Infection by Restoring Junctional Networks
Surface Hydration Protects Cystic Fibrosis Airways from Infection by Restoring Junctional Networks Open
Defective hydration of airway surface mucosa is associated with recurrent lung infection in cystic fibrosis (CF), a disease caused by CF transmembrane conductance regulator (CFTR) gene mutations. Whether the composition and/or presence of …
View article: Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns
Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns Open
Multidrug resistance infections are the main cause of failure in the pro-regenerative cell-mediated therapy of burn wounds. The collagen-based matrices for delivery of cells could be potential substrates to support bacterial growth and sub…
View article: Combined Bacteriophage and Antibiotic Treatment Prevents Pseudomonas aeruginosa Infection of Wild Type and cftr- Epithelial Cells
Combined Bacteriophage and Antibiotic Treatment Prevents Pseudomonas aeruginosa Infection of Wild Type and cftr- Epithelial Cells Open
With the increase of infections due to multidrug resistant bacterial pathogens and the shortage of antimicrobial molecules with novel targets, interest in bacteriophages as a therapeutic option has regained much attraction. Before the laun…
View article: Adaptive and Mutational Responses to Peptide Dendrimer Antimicrobials in Pseudomonas aeruginosa
Adaptive and Mutational Responses to Peptide Dendrimer Antimicrobials in Pseudomonas aeruginosa Open
Colistin (polymyxin E) is a last-resort antibiotic against multidrug-resistant isolates of Pseudomonas aeruginosa . However, the nephro-toxicity of colistin limits its use, spurring the interest in novel antimicrobial peptides (AMP). Here,…
View article: Lowe syndrome–linked endocytic adaptors direct membrane cycling kinetics with OCRL in <i>Dictyostelium discoideum</i>
Lowe syndrome–linked endocytic adaptors direct membrane cycling kinetics with OCRL in <i>Dictyostelium discoideum</i> Open
Mutations of the inositol 5-phosphatase OCRL cause Lowe syndrome (LS), characterized by congenital cataract, low IQ, and defective kidney proximal tubule resorption. A key subset of LS mutants abolishes OCRL’s interactions with endocytic a…
View article: Lowe Syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in<i>Dictyostelium discoideum</i>
Lowe Syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in<i>Dictyostelium discoideum</i> Open
Summary Mutations of the inositol 5-phosphatase OCRL cause Lowe Syndrome (LS), characterized by congenital cataract, low IQ and defective kidney proximal tubule resorption. A key subset of LS mutants abolishes OCRL’s interactions with endo…
View article: Additional file 3: of Transcriptional profiling of Pseudomonas aeruginosa and Staphylococcus aureus during in vitro co-culture
Additional file 3: of Transcriptional profiling of Pseudomonas aeruginosa and Staphylococcus aureus during in vitro co-culture Open
Table S1. Differentially expressed genes in S. aureus in co-culture versus mono-culture (average of three replicates, after normalization). (XLSX 35 kb)
View article: Additional file 4: of Transcriptional profiling of Pseudomonas aeruginosa and Staphylococcus aureus during in vitro co-culture
Additional file 4: of Transcriptional profiling of Pseudomonas aeruginosa and Staphylococcus aureus during in vitro co-culture Open
Table S2. Differentially expressed genes in P. aeruginosa in co-culture versus mono-culture (average of three replicates, after normalization). (XLSX 36 kb)
View article: Additional file 6: of Transcriptional profiling of Pseudomonas aeruginosa and Staphylococcus aureus during in vitro co-culture
Additional file 6: of Transcriptional profiling of Pseudomonas aeruginosa and Staphylococcus aureus during in vitro co-culture Open
Table S4. Primers used in this study. (DOCX 18 kb)
View article: TonB-Dependent Receptor Repertoire of Pseudomonas aeruginosa for Uptake of Siderophore-Drug Conjugates
TonB-Dependent Receptor Repertoire of Pseudomonas aeruginosa for Uptake of Siderophore-Drug Conjugates Open
The conjugation of siderophores to antimicrobial molecules is an attractive strategy to overcome the low outer membrane permeability of Gram-negative bacteria. In this Trojan horse approach, the transport of drug conjugates is redirected v…
View article: Co-evolution with <i>Staphylococcus aureus</i> leads to lipopolysaccharide alterations in <i>Pseudomonas aeruginosa</i>
Co-evolution with <i>Staphylococcus aureus</i> leads to lipopolysaccharide alterations in <i>Pseudomonas aeruginosa</i> Open
Detrimental and beneficial interactions between co-colonizing bacteria may influence the course of infections. In cystic fibrosis (CF) airways, Staphylococcus aureus prevails in childhood, whereas Pseudomonas aeruginosa progressively predo…
View article: Structure and Function of the PiuA and PirA Siderophore-Drug Receptors from Pseudomonas aeruginosa and Acinetobacter baumannii
Structure and Function of the PiuA and PirA Siderophore-Drug Receptors from Pseudomonas aeruginosa and Acinetobacter baumannii Open
The outer membrane of Gram-negative bacteria presents an efficient barrier to the permeation of antimicrobial molecules. One strategy pursued to circumvent this obstacle is to hijack transport systems for essential nutrients, such as iron.…
View article: Design, crystal structure and atomic force microscopy study of thioether ligated<scp>d</scp>,<scp>l</scp>-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa
Design, crystal structure and atomic force microscopy study of thioether ligated<span>d</span>,<span>l</span>-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa Open
A new family of cyclic antimicrobial peptides is reported targeting multidrug resistantPseudomonas aeruginosaby membrane disruption.