Alexandre Matet
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View article: Steroidome Dysregulation and Complement C4 Copy Number Variation in Men with Central Serous Chorioretinopathy
Steroidome Dysregulation and Complement C4 Copy Number Variation in Men with Central Serous Chorioretinopathy Open
Background Central serous chorioretinopathy (CSCR) predominantly affects middle-aged men, in which systemic glucocorticoid exposure is a well-established risk factor. Genetic studies have implicated copy number variation (CNV) in complemen…
View article: Genetic Background Predicts Uveal Melanoma Patients’ Outcomes
Genetic Background Predicts Uveal Melanoma Patients’ Outcomes Open
Objective: Single nucleotide polymorphisms (SNPs) in IRF4 and HERC2 are associated with risk for disomy or monosomy of chromosome 3 (D3 or M3) uveal melanoma (UM), respectively. The aim of this study was to assess the association between g…
View article: Correction: Practical guidelines on imaging of retinoblastoma: a 2025 update on behalf of the European Retinoblastoma Imaging Collaboration and the European Retinoblastoma Group
Correction: Practical guidelines on imaging of retinoblastoma: a 2025 update on behalf of the European Retinoblastoma Imaging Collaboration and the European Retinoblastoma Group Open
View article: Practical guidelines on imaging of retinoblastoma: a 2025 update on behalf of the European Retinoblastoma Imaging Collaboration and the European Retinoblastoma Group
Practical guidelines on imaging of retinoblastoma: a 2025 update on behalf of the European Retinoblastoma Imaging Collaboration and the European Retinoblastoma Group Open
Retinoblastoma is the most common intraocular malignancy in children. Imaging plays a crucial role in evaluating children with retinoblastoma, both to determine tumor extension and to confirm the diagnosis when necessary. The eighth editio…
View article: Preliminary evidence of CAR T‐cell therapy activity in vitreoretinal lymphomas: An LOC network study
Preliminary evidence of CAR T‐cell therapy activity in vitreoretinal lymphomas: An LOC network study Open
View article: 336 | CAR T‐CELL THERAPY IS HIGHLY EFFECTIVE IN VITREORETINAL LYMPHOMAS. A LOC NETWORK STUDY
336 | CAR T‐CELL THERAPY IS HIGHLY EFFECTIVE IN VITREORETINAL LYMPHOMAS. A LOC NETWORK STUDY Open
View article: Intraocular Myxo-Papillary Ependymoma versus Retinal Gliosis Mimicking Uveal Melanoma: Report of 2 Adult Patients with Clinical, Imaging, and Histopathologic Features
Intraocular Myxo-Papillary Ependymoma versus Retinal Gliosis Mimicking Uveal Melanoma: Report of 2 Adult Patients with Clinical, Imaging, and Histopathologic Features Open
Introduction: To report two cases of primary retinal ependymoma occurring in adults, both enucleated following initial suspicion of uveal melanoma. Uveal melanoma is the most frequent primary tumor of the eye in adults but other rare benig…
View article: Anxiety, depression and fear of cancer recurrence in uveal melanoma survivors and ophthalmologist/oncologist communication during survivorship in France – protocol of a prospective observational mixed-method study
Anxiety, depression and fear of cancer recurrence in uveal melanoma survivors and ophthalmologist/oncologist communication during survivorship in France – protocol of a prospective observational mixed-method study Open
View article: Role of inflammation in a rat model of radiation retinopathy
Role of inflammation in a rat model of radiation retinopathy Open
View article: Lymph Node Evolution in Eyelid and Orbit Squamous Cell Carcinomas
Lymph Node Evolution in Eyelid and Orbit Squamous Cell Carcinomas Open
Objectives To describe a large cohort of eyelid and periorbital SCCs, to compare the location of the tumor and of the pathological lymph nodes, and to analyze the risk factors for lymph node involvement among tumor characteristics. Methods…
View article: Intraocular Invasion by Conjunctival Squamous Cell Carcinoma: Clinical Presentation, Histopathological Findings, and Outcome
Intraocular Invasion by Conjunctival Squamous Cell Carcinoma: Clinical Presentation, Histopathological Findings, and Outcome Open
Introduction: Intraocular localization of conjunctival squamous cell carcinoma (SCC) is due to scleral or corneal invasion. Herein, we describe the clinical and histopathological findings in four cases of SCC complicated by i…
View article: Optical Density Ratio of Subretinal Fluid in Choroidal Melanomas Versus Choroidal Naevi Assessed by Optical Coherence Tomography
Optical Density Ratio of Subretinal Fluid in Choroidal Melanomas Versus Choroidal Naevi Assessed by Optical Coherence Tomography Open
SRF ODR is higher in choroidal melanoma compared to choroidal naevi. This OCT-derived imaging marker is also higher in choroidal naevi with the potential to transform into melanoma, compared to stationary naevi.
View article: High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy
High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy Open
View article: Diffuse Infiltrating Retinoblastoma with Anterior Chamber Involvement: Conservative Management and Identification of RB1 Alterations in Aqueous Humor
Diffuse Infiltrating Retinoblastoma with Anterior Chamber Involvement: Conservative Management and Identification of RB1 Alterations in Aqueous Humor Open
Introduction: The aim of the study was to describe the successful conservative management of diffuse infiltrating retinoblastoma (DIR). Identification of RB1 pathogenic variant was done after cell-free DNA (cfDNA) analysis in aqueous humor…
View article: L1CAM and laminin vascular network: Association with the high-risk replacement histopathologic growth pattern in uveal melanoma liver metastases
L1CAM and laminin vascular network: Association with the high-risk replacement histopathologic growth pattern in uveal melanoma liver metastases Open
View article: Nivolumab plus ipilimumab in metastatic uveal melanoma: a real-life, retrospective cohort of 47 patients
Nivolumab plus ipilimumab in metastatic uveal melanoma: a real-life, retrospective cohort of 47 patients Open
Introduction: Although combined PD-1/CTLA-4 inhibition showed limited efficacy in single-arm, phase II trials in metastatic uveal melanoma (mUM), such combination appears frequently used in mUM patients. We here report our experience with …
View article: Non-Cancer Effects following Ionizing Irradiation Involving the Eye and Orbit
Non-Cancer Effects following Ionizing Irradiation Involving the Eye and Orbit Open
The eye is an exemplarily challenging organ to treat when considering ocular tumors. It is at the crossroads of several major aims in oncology: tumor control, organ preservation, and functional outcomes including vision and quality of life…
View article: Implantation iris cysts developing 24 years after penetrating keratoplasty
Implantation iris cysts developing 24 years after penetrating keratoplasty Open
View article: A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression Open
View article: Effect of eplerenone on choroidal blood flow changes during isometric exercise in patients with chronic central serous chorioretinopathy
Effect of eplerenone on choroidal blood flow changes during isometric exercise in patients with chronic central serous chorioretinopathy Open
Purpose To investigate choroidal blood flow changes after isometric exercise in patients with chronic central serous chorioretinopathy nontreated or treated with mineralocorticoid receptor antagonists (MRA). Methods Foveolar choroidal lase…
View article: Impact of integrating objective structured clinical examination into academic student assessment: Large-scale experience in a French medical school
Impact of integrating objective structured clinical examination into academic student assessment: Large-scale experience in a French medical school Open
Purpose Objective structured clinical examinations (OSCE) evaluate clinical reasoning, communication skills, and interpersonal behavior during medical education. In France, clinical training has long relied on bedside clinical practice in …
View article: An in vitro Model of Human Retinal Detachment Reveals Successive Death Pathway Activations
An in vitro Model of Human Retinal Detachment Reveals Successive Death Pathway Activations Open
Purpose was to create an in vitro model of human retinal detachment (RD) to study the mechanisms of photoreceptor death. Methods Human retinas were obtained through eye globe donations for research purposes and cultivated as explants. Cell…
View article: Lipocalin 2 as a potential systemic biomarker for central serous chorioretinopathy
Lipocalin 2 as a potential systemic biomarker for central serous chorioretinopathy Open
No systemic biomarker of Central Serous Chorioretinopathy (CSCR) has been identified. Lipocalin 2 (LCN2 or NGAL), alone or complexed with MMP-9 (NGAL/MMP-9), is increased in several retinal disorders. Serum levels of LCN2 and NGAL/MMP-9 we…
View article: Improved clinical communication OSCE scores after simulation-based training: Results of a comparative study
Improved clinical communication OSCE scores after simulation-based training: Results of a comparative study Open
These results support the early introduction of practical training to improve communication skills in undergraduate medical curricula. Studies are required to assess the sustainability of this improvement over time and its effect on furthe…
View article: Les œdèmes maculaires
Les œdèmes maculaires Open
L’œdème maculaire est une augmentation de volume de la macula, zone centrale de la rétine, responsable de l’acuité visuelle. Des symptômes visuels handicapent la vie de millions de patients atteints d’œdème maculaire secondaire à une malad…
View article: Les œdèmes maculaires
Les œdèmes maculaires Open
View article: Lipocalin 2 is decreased in the serum of patients with Central Serous Chorioretinopathy: Towards a biomarker?
Lipocalin 2 is decreased in the serum of patients with Central Serous Chorioretinopathy: Towards a biomarker? Open
View article: Germline <i>MBD4</i> Mutations and Predisposition to Uveal Melanoma
Germline <i>MBD4</i> Mutations and Predisposition to Uveal Melanoma Open
Background Uveal melanoma (UM) arises from malignant transformation of melanocytes in the uveal tract of the eye. This rare tumor has a poor outcome with frequent chemo-resistant liver metastases. BAP1 is the only known predisposing gene f…
View article: Uveal Melanoma Management for Medical Oncologists in 2020
Uveal Melanoma Management for Medical Oncologists in 2020 Open
Uveal melanoma is a rare subtype of melanoma, intrinsically different from cutaneous melanoma. Despite optimal therapeutic management allowing local control of the primary ocular tumor, 20 to 50% of patients develop met... | Find, read and…
View article: Levels of the oxidative stress biomarker malondialdehyde in tears of patients with central serous chorioretinopathy relate to disease activity.
Levels of the oxidative stress biomarker malondialdehyde in tears of patients with central serous chorioretinopathy relate to disease activity. Open
Levels of MDA in tears, measured with an optimized analytical method, correlate with RPE leakage in CSCR.