Alexandre Méloux
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View article: Electrical Stimulation‐Induced Muscle Damage Alters Hippocampal BDNF Signaling
Electrical Stimulation‐Induced Muscle Damage Alters Hippocampal BDNF Signaling Open
This study investigates whether electrical stimulation (ES) could mimic traditional exercise in enhancing brain‐derived neurotrophic factor (BDNF)‐dependent neuroplasticity via muscle‐brain communication, specifically through the fibronect…
View article: Anxio-depressive phenotype and impaired memory in mice with a conditional knockout of brain-derived neurotrophic factor in endothelial cells
Anxio-depressive phenotype and impaired memory in mice with a conditional knockout of brain-derived neurotrophic factor in endothelial cells Open
The study provides the proof of concept that endothelial brain-derived neurotrophic factor (BDNF) plays a crucial role in postnatal synaptogenesis and development of behavior/memory. It also shows that neuronal tropomyosin-related kinase t…
View article: Proximal and distant expression of growth differentiation factor 15 (GDF15) correlate with neurological deficit following experimental ischemic stroke
Proximal and distant expression of growth differentiation factor 15 (GDF15) correlate with neurological deficit following experimental ischemic stroke Open
Background and purpose Growth differentiation factor 15 (GDF15) has emerged as a promising biomarker in cerebro-cardiovascular disease, particularly in acute and chronic inflammatory stress situations. However, understanding the origins, t…
View article: Cerebral Benefits Induced by Electrical Muscle Stimulation: Evidence from a Human and Rat Study
Cerebral Benefits Induced by Electrical Muscle Stimulation: Evidence from a Human and Rat Study Open
Physical exercise (EX) is well established for its positive impact on brain health. However, conventional EX may not be feasible for certain individuals. In this regard, this study explores electromyostimulation (EMS) as a potential altern…
View article: Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin
Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin Open
The positive effects of physical exercise (EX) are well known to be mediated by cerebral BDNF (brain-derived neurotrophic factor), a neurotrophin involved in learning and memory, the expression of which could be induced by circulating iris…
View article: Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction
Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction Open
Accumulating evidence supports that physical exercise (EX) is the most effective non-pharmacological strategy to improve brain health. EX prevents cognitive decline associated with age and decreases the risk of developing neurodegenerative…
View article: Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study
Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study Open
Background Atrial cardiomyopathy (AC) is an emerging concept explaining the pathophysiology of cardioembolic strokes in absence of atrial fibrillation (AF). A definition based on the presence of electrical abnormality (P-wave terminal forc…
View article: Multimodal Approach for the Prediction of Atrial Fibrillation Detected After Stroke: SAFAS Study
Multimodal Approach for the Prediction of Atrial Fibrillation Detected After Stroke: SAFAS Study Open
Background Intensive screening for atrial fibrillation (AF) has led to a better recognition of this cause in stroke patients. However, it is currently debated whether AF Detected After Stroke (AFDAS) has the same pathophysiology and emboli…
View article: Association between Serum Osteoprotegerin Levels and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction
Association between Serum Osteoprotegerin Levels and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction Open
Background. Osteoprotegerin (OPG), a glycoprotein of the tumour necrosis factor (TNF) superfamily, is one of the main biomarkers for vascular calcification. Aim. We aimed to evaluate the association between serum OPG levels and extent of c…
View article: Mitochondrial SLC25 Carriers: Novel Targets for Cancer Therapy
Mitochondrial SLC25 Carriers: Novel Targets for Cancer Therapy Open
The transfer of metabolites through the mitochondrial membranes is a vital process that is highly controlled and regulated by the inner membrane. A variety of metabolites, nucleotides, and cofactors are transported across the inner mitocho…
View article: Anti-Aging Effects of GDF11 on Skin
Anti-Aging Effects of GDF11 on Skin Open
Human skin is composed of three layers: the epidermis, the dermis, and the hypodermis. The epidermis has four major cell layers made up of keratinocytes in varying stages of progressive differentiation. Skin aging is a multi-factorial proc…
View article: Association Between Growth Differentiation Factor-15 and Heart Failure Complicating Acute Myocardial Infarction
Association Between Growth Differentiation Factor-15 and Heart Failure Complicating Acute Myocardial Infarction Open
International audience
View article: Growth Differentiation Factor-8 (GDF8)/Myostatin Is a Predictor of Troponin I Peak and a Marker of Clinical Severity after Acute Myocardial Infarction
Growth Differentiation Factor-8 (GDF8)/Myostatin Is a Predictor of Troponin I Peak and a Marker of Clinical Severity after Acute Myocardial Infarction Open
Objective: Growth differentiation factor-8 (GDF8), also known as myostatin, is a member of the transforming growth factor-β superfamily that inhibits skeletal muscle growth. We aimed to investigate the association between GDF8 and peak tro…
View article: Brain-Heart Interactions During Ischemic Processes
Brain-Heart Interactions During Ischemic Processes Open
International audience
View article: Growth Differentiation Factor-15 (GDF-15) Is Associated With Mortality in Ischemic Stroke Patients Treated With Acute Revascularization Therapy
Growth Differentiation Factor-15 (GDF-15) Is Associated With Mortality in Ischemic Stroke Patients Treated With Acute Revascularization Therapy Open
Background and Aims: Growth differentiation factor-15 (GDF-15) has been identified as a robust marker of developing cardiovascular disease, however, little is currently known about its prognostic value in stroke patients. In a context of g…
View article: The Role of Osteoprotegerin and Its Ligands in Vascular Function
The Role of Osteoprotegerin and Its Ligands in Vascular Function Open
The superfamily of tumor necrosis factor (TNF) receptors includes osteoprotegerin (OPG) and its ligands, which are receptor activators of nuclear factor kappa-B ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL). The OPG/RANK…
View article: Regenerative Capacity of Endogenous Factor: Growth Differentiation Factor 11; a New Approach of the Management of Age-Related Cardiovascular Events
Regenerative Capacity of Endogenous Factor: Growth Differentiation Factor 11; a New Approach of the Management of Age-Related Cardiovascular Events Open
Aging is a complicated pathophysiological process accompanied by a wide array of biological adaptations. The physiological deterioration correlates with the reduced regenerative capacity of tissues. The rejuvenation of tissue regeneration …
View article: Ischemic Stroke Increases Heart Vulnerability to Ischemia-Reperfusion and Alters Myocardial Cardioprotective Pathways
Ischemic Stroke Increases Heart Vulnerability to Ischemia-Reperfusion and Alters Myocardial Cardioprotective Pathways Open
Background and Purpose— For years, the relationship between cardiac and neurological ischemic events has been limited to overlapping pathophysiological mechanisms and common risk factors. However, acute stroke may induce dramatic changes i…
View article: 1203Post-ischemic stroke-induced myocardial dysfunction is associated with nitro-oxidative stress and sympathetic overactivity
1203Post-ischemic stroke-induced myocardial dysfunction is associated with nitro-oxidative stress and sympathetic overactivity Open
tic patients revealed the lowest functional and physical capacity.Systemic inflammation might play a central role in the development of cachexia in chronic stroke. 1201Predictive value of neutrophil-to-lymphocyte ratio for stroke-related o…