Alexandre Storto
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View article: Viral suppression and HIV-1 drug resistance 1 year after pragmatic transitioning to dolutegravir first-line therapy in Malawi: a prospective cohort study
Viral suppression and HIV-1 drug resistance 1 year after pragmatic transitioning to dolutegravir first-line therapy in Malawi: a prospective cohort study Open
For the French and Portuguese translations of the abstract see Supplementary Materials section.
View article: Erratum to: Prevalence of genotypic baseline risk factors for cabotegravir + rilpivirine failure among ARV-naive patients
Erratum to: Prevalence of genotypic baseline risk factors for cabotegravir + rilpivirine failure among ARV-naive patients Open
International audience
View article: High-sensitivity SARS-CoV-2 group testing by digital PCR among symptomatic patients in hospital settings
High-sensitivity SARS-CoV-2 group testing by digital PCR among symptomatic patients in hospital settings Open
View article: Performance evaluation of the QIAstat-Dx® Respiratory SARS-CoV-2 Panel
Performance evaluation of the QIAstat-Dx® Respiratory SARS-CoV-2 Panel Open
View article: Evaluation of the RealStar® SARS-CoV-2 RT-PCR kit RUO performances and limit of detection
Evaluation of the RealStar® SARS-CoV-2 RT-PCR kit RUO performances and limit of detection Open
View article: High-sensitivity COVID-19 group testing by digital PCR
High-sensitivity COVID-19 group testing by digital PCR Open
Background: Worldwide demand for SARS-CoV-2 RT-PCR testing is increasing as more countries are impacted by COVID-19 and as testing remains central to contain the spread of the disease, both in countries where the disease is emerging and in…
View article: Prevalence of doravirine-associated resistance mutations in HIV-1-infected antiretroviral-experienced patients from two large databases in France and Italy
Prevalence of doravirine-associated resistance mutations in HIV-1-infected antiretroviral-experienced patients from two large databases in France and Italy Open
Objectives Doravirine, a novel NNRTI, selects for specific mutations in vitro, including mutations at reverse transcriptase (RT) positions 106, 108, 188, 227, 230 and 234. The aim of this study was to examine the prevalence of doravirine-a…
View article: Rare occurrence of doravirine resistance-associated mutations in HIV-1-infected treatment-naive patients
Rare occurrence of doravirine resistance-associated mutations in HIV-1-infected treatment-naive patients Open
The prevalence of doravirine resistance-associated mutations is very low in antiretroviral-naive patients. These results are very reassuring for doravirine use in naive patients.
View article: Evaluation of different analysis pipelines for the detection of HIV-1 minority resistant variants
Evaluation of different analysis pipelines for the detection of HIV-1 minority resistant variants Open
We found an excellent correlation between the various UDS analysis pipelines that we tested. However, our results indicate that specific attention should be paid to low-level MRVs, for which the use of two different analysis pipelines and …
View article: A28 Phylogeographic analysis of HIV-2 ANRS CO5 cohort reveals new trends in HIV-2 epidemic patterns in West Africa
A28 Phylogeographic analysis of HIV-2 ANRS CO5 cohort reveals new trends in HIV-2 epidemic patterns in West Africa Open
high-throughput sequencing to observe how SAMHD1 expression alters the mutational profile (frequency and spectra) of integrated proviruses.We will explore how mutation rates of HIV-2 can be manipulated through the use of nucleoside analogs…
View article: Minority resistant variants are also present in HIV-2-infected antiretroviral-naive patients
Minority resistant variants are also present in HIV-2-infected antiretroviral-naive patients Open
In this first study assessing the prevalence of MRV in HIV-2 infection among ART-naive patients, we observed a 2-3-fold higher prevalence of RAM when a 1% detection threshold of mutations was used compared with a 20% threshold. Similarly, …
View article: Phenotypic analysis of HIV-1 E157Q integrase polymorphism and impact on virological outcome in patients initiating an integrase inhibitor-based regimen
Phenotypic analysis of HIV-1 E157Q integrase polymorphism and impact on virological outcome in patients initiating an integrase inhibitor-based regimen Open
Assessment of virological response in 39 patients initiating an INI-based regimen with E157Q-mutated virus, in combination with phenotypic analysis, suggests that particular attention should be paid to antiretroviral-naive patients and dol…
View article: Disparities in <scp>HIV</scp>‐1 transmitted drug resistance detected by ultradeep sequencing between men who have sex with men and heterosexual populations
Disparities in <span>HIV</span>‐1 transmitted drug resistance detected by ultradeep sequencing between men who have sex with men and heterosexual populations Open
Objectives Transmitted drug resistance ( TDR ) can impair the response to first‐line antiretroviral therapy. In treatment‐naïve patients chronically infected with HIV type 1 ( HIV ‐1), it was previously shown through Sanger sequencing that…
View article: Correlation between HIV-2 RNA and HIV-2 total DNA levels
Correlation between HIV-2 RNA and HIV-2 total DNA levels Open