Alexandre Trapp
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Molecular signatures of longevity identify compounds that extend mouse lifespan and healthspan Open
Longevity interventions in mammals are typically discovered on a case-by-case basis, hindering systematic geroprotector development. We developed a platform for the identification of longevity interventions integrating longevity gene expre…
View article: Disagreement on foundational principles of biological aging
Disagreement on foundational principles of biological aging Open
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational is…
View article: Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles
Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles Open
Decades of publicly available molecular studies have generated millions of samples testing diverse interventions, yet these datasets were rarely analyzed for their effects on aging. Aging clocks now enable biological age estimation and lif…
Epigenetic profiling and incidence of disrupted development point to gastrulation as aging ground zero in <i>Xenopus laevis</i> Open
Recent studies suggest the existence of a natural rejuvenation event during early embryonic development of mice, followed by epigenetic aging. Here, by profiling embryonic DNA methylation in the African clawed frog, Xenopus laevis , we fou…
View article: Meeting Report: Aging Research and Drug Discovery
Meeting Report: Aging Research and Drug Discovery Open
Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is expanding alongside a growing focus from the i…
Epigenetic aging of the demographically non-aging naked mole-rat Open
The naked mole-rat (NMR) is an exceptionally long-lived rodent that shows no increase of mortality with age, defining it as a demographically non-aging mammal. Here, we perform bisulfite sequencing of the blood of > 100 NMRs, assessing > 3…
View article: Emerging rejuvenation strategies—Reducing the biological age
Emerging rejuvenation strategies—Reducing the biological age Open
Several interventions have recently emerged that were proposed to reverse rather than just attenuate aging, but the criteria for what it takes to achieve rejuvenation remain controversial. Distinguishing potential rejuvenation therapies fr…
Profiling Epigenetic Age in Single Cells Open
DNA methylation of a defined set of CpG dinucleotides emerged as a critical and precise biomarker of the aging process. Multi-variate machine learning models, known as epigenetic clocks, can exploit quantitative changes in the methylome to…
TIME-Seq Enables Scalable and Inexpensive Epigenetic Age Predictions Open
Epigenetic “clocks” based on DNA methylation (DNAme) have emerged as the most robust and widely employed aging biomarkers, but conventional methods for applying them are expensive and laborious. Here, we develop T agmentation-based Indexin…
Cost-effective epigenetic age profiling in shallow methylation sequencing data Open
There is a critical need for robust, high-throughput assays of biological aging trajectories. Among various approaches, epigenetic aging clocks emerged as reliable molecular trackers of the aging process. However, current methods for epige…
View article: Ectopic cervical thymi and no thymic involution until midlife in naked mole rats
Ectopic cervical thymi and no thymic involution until midlife in naked mole rats Open
Immunosenescence is a hallmark of aging and manifests as increased susceptibility to infection, autoimmunity, and cancer in the elderly. One component of immunosenescence is thymic involution, age‐associated shrinkage of the thymus, observ…
View article: Ectopic cervical thymi and no thymic involution until midlife in naked mole-rats
Ectopic cervical thymi and no thymic involution until midlife in naked mole-rats Open
Immunosenescence is a hallmark of aging and manifests as increased susceptibility to infection, autoimmunity, and cancer in the elderly. One component of immunosenescence is thymic involution, age-associated shrinkage of the thymus, observ…
View article: An abundant myeloid progenitor shapes neonatal hematopoiesis of naked mole-rats
An abundant myeloid progenitor shapes neonatal hematopoiesis of naked mole-rats Open
The naked mole-rat became an attractive model for biomedical research due to its exceptional longevity and resistance to disease, yet the developmental properties of naked mole-rat stem and progenitor compartments are poorly understood. He…
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging Open
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging.
Profiling epigenetic age in single cells Open
DNA methylation of a defined set of CpG dinucleotides emerged as a critical and precise biomarker of the aging process. Multi-variate machine learning models, known as epigenetic clocks, can exploit quantitative changes in the methylome to…
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging Open
The notion that germline cells do not age goes back to the 19 th century ideas of August Weismann. However, being in a metabolically active state, they accumulate damage and other age-related changes over time, i.e., they age. For new life…