François Tremblay
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View article: Are Changes in Corticomotor Excitability Associated with Improved Arm Functional Performance Following a Tailored Strength Training Intervention in Chronic Stroke Survivors?
Are Changes in Corticomotor Excitability Associated with Improved Arm Functional Performance Following a Tailored Strength Training Intervention in Chronic Stroke Survivors? Open
Background/Objectives: We showed that a tailored strengthening intervention based on the size of motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) in the affected hemisphere resulted in an improved affected…
View article: Corticomotor excitability of the pelvic floor muscles in females: Characteristics of motor evoked potentials and test–retest reliability
Corticomotor excitability of the pelvic floor muscles in females: Characteristics of motor evoked potentials and test–retest reliability Open
Our findings highlight the possibility of extending TMS applications to investigate changes in corticomotor excitability that may contribute to conditions that are associated with high PFM tone, such as vulvovaginal pain.
View article: 20 years of the Montreal Cystic Fibrosis Related Diabetes Screening Cohort: key insights
20 years of the Montreal Cystic Fibrosis Related Diabetes Screening Cohort: key insights Open
Introduction The Montreal Cystic Fibrosis Related Diabetes Screening Cohort (MCFC) was established in 2004 to study the prevalence, risk factors and management of cystic fibrosis-related diabetes, a significant extrapulmonary complication …
View article: Long-term benefits of a tailored strength training intervention on arm function in chronic stroke survivors: a follow-up study
Long-term benefits of a tailored strength training intervention on arm function in chronic stroke survivors: a follow-up study Open
Objective: We showed that a tailored strengthening intervention based on the size of motor evoked potentials (MEPs) in the affected arm was effective in improving function in chronic stroke survivors. Here, we investigated whether the shor…
View article: Association between cystic fibrosis transmembrane regulator genotype and clinical outcomes, glucose homeostasis indices and CF-related diabetes risk in adults with CF
Association between cystic fibrosis transmembrane regulator genotype and clinical outcomes, glucose homeostasis indices and CF-related diabetes risk in adults with CF Open
People living with cystic fibrosis (pwCF) homozygous for F508del present more severe phenotypes. PwCF with compound heterozygous genotypes F508del /A455E and F508del /L206W may have milder cystic fibrosis (CF) phenotypes. We compared F508d…
View article: Effect of a tailored upper extremity strength training intervention combined with direct current stimulation in chronic stroke survivors: A Randomized Controlled Trial
Effect of a tailored upper extremity strength training intervention combined with direct current stimulation in chronic stroke survivors: A Randomized Controlled Trial Open
Strengthening exercises are recommended for managing persisting upper limb (UL) weakness following a stroke. Yet, strengthening exercises often lead to variable gains because of their generic nature. For this randomized controlled trial (R…
View article: Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4
Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4 Open
Protease-activated receptor 4 (PAR4) is a G-protein coupled receptor that is expressed on human platelets and activated by the coagulation enzyme thrombin. PAR4 plays a key role in blood coagulation, and its importance in pathological thro…
View article: Ultrasound-Derived Diaphragm Contractile Reserve as a Marker of Clinical Status in Patients With Cystic Fibrosis
Ultrasound-Derived Diaphragm Contractile Reserve as a Marker of Clinical Status in Patients With Cystic Fibrosis Open
Introduction: In patients with cystic fibrosis (CF), the monitoring of respiratory muscle activity using electromyography can provide information on the demand-to-capacity ratio of the respiratory system and act as a clinical marker of dis…
View article: Facilitation of Motor Evoked Potentials in Response to a Modified 30 Hz Intermittent Theta-Burst Stimulation Protocol in Healthy Adults
Facilitation of Motor Evoked Potentials in Response to a Modified 30 Hz Intermittent Theta-Burst Stimulation Protocol in Healthy Adults Open
Theta-burst stimulation (TBS) is a form of repetitive transcranial magnetic stimulation (rTMS) developed to induce neuroplasticity. TBS usually consists of 50 Hz bursts at 5 Hz intervals. It can facilitate motor evoked potentials (MEPs) wh…
View article: Combined Indeterminate and Impaired Glucose Tolerance Is a Novel Group at High Risk of Cystic Fibrosis-Related Diabetes
Combined Indeterminate and Impaired Glucose Tolerance Is a Novel Group at High Risk of Cystic Fibrosis-Related Diabetes Open
Background Indeterminate glycemia (INDET) and impaired glucose tolerance (IGT) are independently associated with cystic fibrosis-related diabetes (CFRD) risk. We determined whether patients meeting both criteria have increased risk of diab…
View article: CCDC 1937149: Experimental Crystal Structure Determination
CCDC 1937149: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Hepatic enzyme ALT as a marker of glucose abnormality in men with cystic fibrosis
Hepatic enzyme ALT as a marker of glucose abnormality in men with cystic fibrosis Open
Adult CF men with higher ALT show an increased frequency of dysglycemia and de novo CFRD, lower insulin sensitivity and higher eight. Our data suggests that ALT levels could be an interesting tool to guide targeted diabetes screening, part…
View article: Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy
Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy Open
In an effort to identify novel antithrombotics, we have investigated protease-activated receptor 4 (PAR4) antagonism by developing and evaluating a tool compound, UDM-001651, in a monkey thrombosis model. Beginning with a high-throughput s…
View article: Data for: Differential Modulation of Mechanical Pain Threshold in response to Transcutaneous Spinal Direct Current Stimulation with Physical Activity Level
Data for: Differential Modulation of Mechanical Pain Threshold in response to Transcutaneous Spinal Direct Current Stimulation with Physical Activity Level Open
Data showed variations in pain pressure thresholds determined at three sites in the lower extremity in two groups (MOD, moderately active, High, highly active) of young healthy adults before T0) and after (T5, T30) application of transcuta…
View article: Examining the Interactions Between Expectations and tDCS Effects on Motor and Cognitive Performance
Examining the Interactions Between Expectations and tDCS Effects on Motor and Cognitive Performance Open
Background: Despite a growing literature and commercial market, the effectiveness of transcranial direct current stimulation (tDCS) remains questionable. Notably, studies rarely examine factors such as expectations of outcomes, which may i…
View article: Modulation of corticomotor excitability in response to distal focal cooling
Modulation of corticomotor excitability in response to distal focal cooling Open
Background Thermal stimulation has been proposed as a modality to facilitate motor recovery in neurological populations, such as stroke. Recently (Ansari, Remaud & Tremblay, 2018), we showed that application of cold or warm stimuli distall…
View article: Peer Review #1 of "Modulation of corticomotor excitability in response to distal focal cooling (v0.1)"
Peer Review #1 of "Modulation of corticomotor excitability in response to distal focal cooling (v0.1)" Open
Background: Thermal stimulation has been proposed as a modality to facilitate motor recovery in neurological populations, such as stroke.Recently (Ansari et al. 2018) , we showed that application of cold or warm stimuli distally to a singl…
View article: Peer Review #1 of "Modulation of corticomotor excitability in response to distal focal cooling (v0.2)"
Peer Review #1 of "Modulation of corticomotor excitability in response to distal focal cooling (v0.2)" Open
Background: Thermal stimulation has been proposed as a modality to facilitate motor recovery in neurological populations, such as stroke.Recently (Ansari et al. 2018) , we showed that application of cold or warm stimuli distally to a singl…
View article: Adrenal Insufficiency in Cystic Fibrosis: A Rare Phenomenon?
Adrenal Insufficiency in Cystic Fibrosis: A Rare Phenomenon? Open
Background . The prevalence of adrenal insufficiency (AI) in cystic fibrosis (CF) is unknown. The frequent use of glucocorticoids (inhaled or systemic) may induce the long-term suppression of the hypothalamic-pituitary-adrenal axis. Method…
View article: Age differences in tactile pattern recognition at the fingertip
Age differences in tactile pattern recognition at the fingertip Open
Young (21-26 years, n=20) and Old (55-86 years, n=25) participants were tested for their ability to recognize raised letters (6-mm high, 1-mm relief) by touch. Spatial resolution thresholds were also measured with grating domes to derive a…
View article: IAU volume 13 issue S337 Cover and Front matter
IAU volume 13 issue S337 Cover and Front matter Open
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