Alexandru Odainic
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View article: Alterations in CNS-derived blood biomarkers during 30 days simulated microgravity
Alterations in CNS-derived blood biomarkers during 30 days simulated microgravity Open
Introduction Spaceflight induces physiological adaptations, including headward fluid shifts that may impact the central nervous system (CNS). Ground-based analogs such as 6° head-down tilt bed rest (HDTBR) provide a controlled setting to s…
View article: Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes
Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes Open
Microglia are crucial for maintaining brain health and neuron function. Here, we report that microglia establish connections with neurons using tunneling nanotubes (TNTs) in both physiological and pathological conditions. These TNTs facili…
View article: NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing
NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing Open
The blood proteome holds great promise for precision medicine but poses substantial challenges due to the low abundance of most plasma proteins and the vast dynamic range of the plasma proteome. Here we address these challenges with NUclei…
View article: No evidence for neuronal damage or astrocytic activation in cerebrospinal fluid of Neuro-COVID-19 patients with long-term persistent headache
No evidence for neuronal damage or astrocytic activation in cerebrospinal fluid of Neuro-COVID-19 patients with long-term persistent headache Open
View article: A multi-organ map of the human immune system across age, sex and ethnicity
A multi-organ map of the human immune system across age, sex and ethnicity Open
Summary Understanding tissue biology’s heterogeneity is crucial for advancing precision medicine. Despite the centrality of the immune system in tissue homeostasis, a detailed and comprehensive map of immune cell distribution and interacti…
View article: CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity
CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity Open
Antiviral CD8+ T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these signals for decoding by T cells remains unclear. Here, we describe gradual interfero…
View article: NULISA: a novel proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing
NULISA: a novel proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing Open
The blood proteome holds great promise for precision medicine but poses substantial challenges due to the low abundance of most plasma proteins and the vast dynamic range across the proteome. We report a novel proteomic technology – NUclei…
View article: Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury
Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury Open
View article: Toll-like receptor-3 contributes to the development of aortic valve stenosis
Toll-like receptor-3 contributes to the development of aortic valve stenosis Open
Aortic valve stenosis (AS) development is driven by distinct molecular and cellular mechanisms which include inflammatory pathways. Toll-like-receptor-3 (TLR3) is a lysosomal pattern-recognition receptor that binds double-stranded RNA and …
View article: No serological evidence for neuronal damage or reactive gliosis in neuro-COVID-19 patients with long-term persistent headache
No serological evidence for neuronal damage or reactive gliosis in neuro-COVID-19 patients with long-term persistent headache Open
Recent studies have indicated that long-term neurological sequelae after COVID-19 are not accompanied by an increase of canonical biomarkers of central nervous system injury in blood, but subgroup stratifications are lacking. This is a par…
View article: Comparative Analysis of Antibody Titers against the Spike Protein of SARS-CoV-2 Variants in Infected Patient Cohorts and Diverse Vaccination Regimes
Comparative Analysis of Antibody Titers against the Spike Protein of SARS-CoV-2 Variants in Infected Patient Cohorts and Diverse Vaccination Regimes Open
The presence of neutralizing antibodies against SARS-CoV-2 correlates with protection against infection and severe COVID-19 disease courses. Understanding the dynamics of antibody development against the SARS-CoV-2 virus is important for r…
View article: Suppression of systemic T cell immunity to viral infection during liver injury is prevented by inhibition of interferon and IL-10 signaling
Suppression of systemic T cell immunity to viral infection during liver injury is prevented by inhibition of interferon and IL-10 signaling Open
Patients with liver injury such as cirrhosis are at increased risk of intractable viral infections and are hyporesponsive to vaccination. Here, we report that liver injury leads to inhibition of systemic T cell immunity ( LIST ), which abr…
View article: Brain-Derived Neurotrophic Factor in Gestational Diabetes: Analysis of Maternal Serum and Cord Blood Pairs and Comparison of Dietary- and Insulin-Dependent GDM
Brain-Derived Neurotrophic Factor in Gestational Diabetes: Analysis of Maternal Serum and Cord Blood Pairs and Comparison of Dietary- and Insulin-Dependent GDM Open
The Objective of our study was to investigate the influence of dietary (dGDM) and insulin-dependent (iGDM) gestational diabetes (GDM) on BDNF blood levels of corresponding maternal-neonatal pairs and compare them to pregnancies unaffected …
View article: High maternal BMI and low maternal blood BDNF may determine the limit of detection of amniotic fluid BDNF throughout gestation: Analysis of mother-fetus trios and literature review
High maternal BMI and low maternal blood BDNF may determine the limit of detection of amniotic fluid BDNF throughout gestation: Analysis of mother-fetus trios and literature review Open
Objective An increasing number of studies show the importance of brain-derived neurotrophic factor (BDNF) acting at the feto-placental interface, however, only a few studies describe BDNF levels in amniotic fluid (AF). Methods In this cros…
View article: Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination
Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination Open
We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and…
View article: Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes Open
View article: Inferred retinal sensitivity in recessive Stargardt disease using machine learning
Inferred retinal sensitivity in recessive Stargardt disease using machine learning Open
View article: Prediction of Function in ABCA4-Related Retinopathy Using Ensemble Machine Learning
Prediction of Function in ABCA4-Related Retinopathy Using Ensemble Machine Learning Open
Full-field electroretinogram (ERG) and best corrected visual acuity (BCVA) measures have been shown to have prognostic value for recessive Stargardt disease (also called “ABCA4-related retinopathy”). These functional tests may serve as a p…