Alexanne Bouchard
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View article: CD206<sup>+</sup>macrophages are relevant non-invasive imaging biomarkers and therapeutic targets in experimental lung fibrosis
CD206<sup>+</sup>macrophages are relevant non-invasive imaging biomarkers and therapeutic targets in experimental lung fibrosis Open
Background Interstitial lung diseases (ILDs) include a large number of diseases associated with progressive pulmonary fibrosis (PPF), including idiopathic pulmonary fibrosis (IPF). Despite the rarity of each of the fibrotic ILDs individual…
View article: La protéine de stress du réticulum endoplasmique GRP94 dans le cancer du sein triple négatif, intérêt diagnostique et thérapeutique
La protéine de stress du réticulum endoplasmique GRP94 dans le cancer du sein triple négatif, intérêt diagnostique et thérapeutique Open
Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen and progesterone receptors, as well as HER2, on tumor cells. It is the most aggressive subtype of breast cancer and is associated with a higher risk of metast…
View article: The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with 99mTc-Tilmanocept SPECT
The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with 99mTc-Tilmanocept SPECT Open
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancers and is not eligible for hormone and anti-HER2 therapies. Identifying therapeutic targets and associated biomarkers in TNBC is a clinical challenge to imp…
View article: GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment
GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment Open
Glycoprotein-A repetitions predominant (GARP) is the docking receptor for latent transforming growth factor (LTGF-β) and promotes its activation. In cancer, increased GARP expression has been found in many types of cancer. GARP is expresse…