Alexei A. Aravin
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View article: Auto-methylation of the histone methyltransferase SetDB1 at its histone-mimic motifs ensures the spreading and maintenance of heterochromatin
Auto-methylation of the histone methyltransferase SetDB1 at its histone-mimic motifs ensures the spreading and maintenance of heterochromatin Open
Heterochromatin plays a critical role in nuclear organization and the regulation of gene expression by directing 3D genome organization, regulating lineage-specific gene expression, and ensuring the repression of transposable elements and …
View article: Escalation of genome defense capacity enables control of an expanding meiotic driver
Escalation of genome defense capacity enables control of an expanding meiotic driver Open
From RNA interference to chromatin silencing, diverse genome defense pathways silence selfish genetic elements to safeguard genome integrity. Despite their diversity, different defense pathways share a modular organization, where numerous …
View article: Escalation of genome defense capacity enables control of an expanding meiotic driver
Escalation of genome defense capacity enables control of an expanding meiotic driver Open
Summary From RNA interference to chromatin silencing, diverse genome defense pathways silence selfish genetic elements to safeguard genome integrity 1,2 . Despite their diversity, different defense pathways share a modular organization, wh…
View article: Author Response: SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes
Author Response: SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes Open
View article: SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes
SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes Open
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, Dro…
View article: Impact of Germline Depletion of Bonus on Chromatin State in Drosophila Ovaries
Impact of Germline Depletion of Bonus on Chromatin State in Drosophila Ovaries Open
Gene expression is controlled via complex regulatory mechanisms involving transcription factors, chromatin modifications, and chromatin regulatory factors. Histone modifications, such as H3K27me3, H3K9ac, and H3K27ac, play an important rol…
View article: SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes
SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes Open
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, Dro…
View article: Author Response: SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes
Author Response: SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes Open
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, Dro…
View article: Reviewer #1 (Public Review): SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes
Reviewer #1 (Public Review): SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes Open
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, Dro…
View article: Reviewer #2 (Public Review): SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes
Reviewer #2 (Public Review): SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes Open
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, Dro…
View article: Maternally inherited siRNAs initiate piRNA cluster formation
Maternally inherited siRNAs initiate piRNA cluster formation Open
View article: A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila Open
View article: SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes
SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes Open
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, Dro…
View article: SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes
SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes Open
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, Dro…
View article: Pervasive SUMOylation of heterochromatin and piRNA pathway proteins
Pervasive SUMOylation of heterochromatin and piRNA pathway proteins Open
Genome regulation involves complex protein interactions that are often mediated through post-translational modifications (PTMs). SUMOylation-modification by the small ubiquitin-like modifier (SUMO)-has been implicated in numerous essential…
View article: Bacterial Argonaute Proteins Aid Cell Division in the Presence of Topoisomerase Inhibitors in Escherichia coli
Bacterial Argonaute Proteins Aid Cell Division in the Presence of Topoisomerase Inhibitors in Escherichia coli Open
Prokaryotic Argonautes (pAgos) are programmable nucleases with incompletely understood functions in vivo . In contrast to eukaryotic Argonautes, most studied pAgos recognize DNA targets.
View article: Bacterial Argonaute nucleases reveal different modes of DNA targeting <i>in vitro</i> and <i>in vivo</i>
Bacterial Argonaute nucleases reveal different modes of DNA targeting <i>in vitro</i> and <i>in vivo</i> Open
Prokaryotic Argonaute proteins (pAgos) are homologs of eukaryotic Argonautes (eAgos) and are also thought to play a role in cell defense against invaders. However, pAgos are much more diverse than eAgos and little is known about their func…
View article: SUMOylation of Bonus, the <i>Drosophila</i> homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes
SUMOylation of Bonus, the <i>Drosophila</i> homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes Open
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, Dro…
View article: Genetic control of a sex-specific piRNA program
Genetic control of a sex-specific piRNA program Open
View article: Specific targeting of plasmids with Argonaute enables genome editing
Specific targeting of plasmids with Argonaute enables genome editing Open
Prokaryotic Argonautes (pAgos) are programmable nucleases involved in cell defense against invading DNA. In vitro, pAgos can bind small single-stranded guide DNAs to recognize and cleave complementary DNA. In vivo, pAgos preferentially tar…
View article: Abstract 1277: SUMOylation “hot spots” in the piRNA pathway and heterochromatin revealed by diGly proteomics
Abstract 1277: SUMOylation “hot spots” in the piRNA pathway and heterochromatin revealed by diGly proteomics Open
View article: Genetic control of a sex-specific piRNA program
Genetic control of a sex-specific piRNA program Open
Sexually dimorphic traits in morphologies are widely studied, but those in essential molecular pathways remain largely unexplored. Previous work showed substantial sex differences in Drosophila gonadal piRNAs, which guide PIWI proteins to …
View article: <i>Drosophila</i>Males Use 5′-to-3′ Phased Biogenesis to Make<i>Stellate</i>-silencing piRNAs that Lack Homology to Maternally Deposited piRNA Guides
<i>Drosophila</i>Males Use 5′-to-3′ Phased Biogenesis to Make<i>Stellate</i>-silencing piRNAs that Lack Homology to Maternally Deposited piRNA Guides Open
PIWI-interacting RNAs (piRNAs) direct PIWI proteins to silence complementary targets such as transposons. In animals with a maternally specified germline, e.g. Drosophila melanogaster , maternally deposited piRNAs initiate piRNA biogenesis…
View article: Bacterial Argonaute proteins aid cell division in the presence of topoisomerase inhibitors in <i>Escherichia coli</i>
Bacterial Argonaute proteins aid cell division in the presence of topoisomerase inhibitors in <i>Escherichia coli</i> Open
Prokaryotic Argonaute (pAgo) proteins are guide-dependent nucleases that function in host defense against invaders. Recently, it was shown that TtAgo from Thermus thermophilus also participates in the completion of DNA replication by decat…
View article: Bacterial Argonaute nucleases reveal different modes of DNA targeting <i>in vitro</i> and <i>in vivo</i>
Bacterial Argonaute nucleases reveal different modes of DNA targeting <i>in vitro</i> and <i>in vivo</i> Open
Prokaryotic Argonaute proteins (pAgos) are homologs of eukaryotic Argonautes (eAgos) that were similarly proposed to play a role in cell defense against invaders. However, pAgos are much more diverse than eAgos and very little is known abo…
View article: Author Correction: Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity
Author Correction: Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity Open
View article: Pervasive SUMOylation of heterochromatin and piRNA pathway proteins
Pervasive SUMOylation of heterochromatin and piRNA pathway proteins Open
Genome regulation involves complex and highly regulated protein interactions that are often mediated through post-translational modifications (PTMs). SUMOylation – the covalent attachment of the s mall u biquitin-like mo difier (SUMO) – is…
View article: Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity
Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity Open
Argonaute proteins are programmable nucleases that have defense and regulatory functions in both eukaryotes and prokaryotes. All known prokaryotic Argonautes (pAgos) characterized so far act on DNA targets. Here, we describe a new class of…
View article: Specific targeting of plasmids with Argonaute enables genome editing
Specific targeting of plasmids with Argonaute enables genome editing Open
Prokaryotic Argonautes (pAgos) are programmable nucleases involved in cell defense against invading DNA. Recent studies showed that pAgos can bind small single-stranded guide DNAs (gDNAs) to recognize and cleave complementary DNA in vitro.…
View article: Maternally inherited siRNAs initiate piRNA cluster formation
Maternally inherited siRNAs initiate piRNA cluster formation Open
PIWI-interacting RNAs (piRNAs) guide repression of transposable elements in germlines of animals. In Drosophila , piRNAs are produced from heterochromatic genomic loci, called piRNA clusters, that act as a repositories of information about…