Alexi A. Wright
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View article: EOLP-04. When Is It the Right Time? A Qualitative Study of Specialty Palliative Care Timing in Brain Tumor Patients
EOLP-04. When Is It the Right Time? A Qualitative Study of Specialty Palliative Care Timing in Brain Tumor Patients Open
BACKGROUND Central nervous system (CNS) tumors have high morbidity and mortality. However, the optimal timing for specialty palliative care (SPC) in patients with CNS tumors is unknown. We sought to understand how and when SPC should be in…
View article: Barriers and Facilitators to Delivering Cancer Care in US Prisons
Barriers and Facilitators to Delivering Cancer Care in US Prisons Open
Importance Cancer is the leading cause of death in US prisons. Incarcerated patients with cancer have higher mortality than the general population, but little is known about barriers and facilitators to cancer care in prison. Objective To …
View article: Correctional Health and Oncologist Perspectives on Strategies to Improve Cancer Care in US Prisons
Correctional Health and Oncologist Perspectives on Strategies to Improve Cancer Care in US Prisons Open
Importance Individuals diagnosed with cancer while incarcerated in US prisons have worse mortality than nonincarcerated individuals. Incarceration poses numerous barriers to care, and optimal strategies to improve cancer screening, diagnos…
View article: Phase 2 study of Wee1 inhibitor adavosertib in recurrent uterine carcinosarcoma
Phase 2 study of Wee1 inhibitor adavosertib in recurrent uterine carcinosarcoma Open
View article: Frailty, disability, and quality of life in older adults with gynecologic cancer – interim data from the PROmOting gynecologic cancer patients to achieve Functional recovery (PROOF) cohort study
Frailty, disability, and quality of life in older adults with gynecologic cancer – interim data from the PROmOting gynecologic cancer patients to achieve Functional recovery (PROOF) cohort study Open
View article: Usability, Acceptability, and Barriers to Implementation of a Collaborative Agenda-Setting Intervention (CASI) to Promote Person-Centered Ovarian Cancer Care: Development Study
Usability, Acceptability, and Barriers to Implementation of a Collaborative Agenda-Setting Intervention (CASI) to Promote Person-Centered Ovarian Cancer Care: Development Study Open
Background People with advanced ovarian cancer and their caregivers report unmet supportive care needs. We developed a Collaborative Agenda-Setting Intervention (CASI) to elicit patients’ and caregivers’ needs through the patient portal be…
View article: Smartphone-based measures as real-world indicators of functional status in advanced cancer patients
Smartphone-based measures as real-world indicators of functional status in advanced cancer patients Open
Objective This study evaluated the feasibility of using smartphone-based metrics to monitor physical functioning and quality of life in patients with advanced gynecological cancers. We analyzed associations between gait (step count, cadenc…
View article: Outpatient palliative care and end-of-life care intensity: linking Massachusetts Cancer Registry with All-Payer Claims Database
Outpatient palliative care and end-of-life care intensity: linking Massachusetts Cancer Registry with All-Payer Claims Database Open
Background Early palliative care is associated with better outcomes for patients with advanced-stage cancers. Using a novel data linkage, we assessed outpatient palliative care use before death and its association with end-of-life care int…
View article: Phase 2 Study of Wee1 Inhibitor Adavosertib in Recurrent Uterine Carcinosarcoma
Phase 2 Study of Wee1 Inhibitor Adavosertib in Recurrent Uterine Carcinosarcoma Open
View article: Exploring the Relationship Between Smartphone GPS Patterns and Quality of Life in Patients With Advanced Cancer and Their Family Caregivers: Longitudinal Study
Exploring the Relationship Between Smartphone GPS Patterns and Quality of Life in Patients With Advanced Cancer and Their Family Caregivers: Longitudinal Study Open
Background Patients with advanced cancer and their family caregivers often experience poor quality of life (QOL). Self-report measures are commonly used to quantify QOL of family caregivers but may have limitations such as recall bias and …
View article: A comparison of adult-child and spousal cancer caregivers’ participation in medical decisions
A comparison of adult-child and spousal cancer caregivers’ participation in medical decisions Open
Background Family caregivers often play a key role in medical decision-making for patients with cancer. Adult-children account for nearly half of caregivers, but often have less experience with serious illness care and decision-making and …
View article: Worse Depression Profiles Are Associated With Higher Symptom Burden and Poorer Quality of Life in Patients With Gynecologic Cancer
Worse Depression Profiles Are Associated With Higher Symptom Burden and Poorer Quality of Life in Patients With Gynecologic Cancer Open
Background Depression is a pervasive symptom in patients with gynecological cancer undergoing chemotherapy. Objectives Purposes were to identify subgroups of patients with distinct depression profiles and evaluate for differences in demogr…
View article: Experiences of patients with peritoneal carcinomatosis-related complex care needs and their caregivers
Experiences of patients with peritoneal carcinomatosis-related complex care needs and their caregivers Open
View article: Developing a Collaborative Agenda-Setting Intervention (CASI) to promote patient-centered communication in ovarian cancer care: A design thinking approach
Developing a Collaborative Agenda-Setting Intervention (CASI) to promote patient-centered communication in ovarian cancer care: A design thinking approach Open
To our knowledge, the CASI is the first intervention to set the visit agenda and support communication from within the electronic health record. Future research will assess its usability and acceptability.
View article: THE RELATIONSHIP BETWEEN SELF-REPORTED QUALITY OF LIFE AND SMARTPHONE GPS DATA
THE RELATIONSHIP BETWEEN SELF-REPORTED QUALITY OF LIFE AND SMARTPHONE GPS DATA Open
Patients with advanced cancer and their family caregivers often experience poor quality of life. Self-reported measures are commonly used to quantify quality of life of family caregivers but may have limitations such as recall and social d…
View article: Open-Source, Step-Counting Algorithm for Smartphone Data Collected in Clinical and Nonclinical Settings: Algorithm Development and Validation Study
Open-Source, Step-Counting Algorithm for Smartphone Data Collected in Clinical and Nonclinical Settings: Algorithm Development and Validation Study Open
Background Step counts are increasingly used in public health and clinical research to assess well-being, lifestyle, and health status. However, estimating step counts using commercial activity trackers has several limitations, including a…
View article: PR072/#1519 Effort: clinical and molecular features associated with clinical benefit from adavosertib with or without olaparib in recurrent ovarian cancer following progression on PARP inhibition (NCT03579316)
PR072/#1519 Effort: clinical and molecular features associated with clinical benefit from adavosertib with or without olaparib in recurrent ovarian cancer following progression on PARP inhibition (NCT03579316) Open
Introduction EFFORT, a randomized noncomparative phase II study of adavosertib (WEE1 inhibitor) +/- olaparib [poly (ADP-ribose) polymerase inhibitor (PARPi)] in patients with PARPi-resistant ovarian cancer (OC), demonstrated efficacy and m…
View article: Opportunities for Savings in Risk Arrangements for Oncologic Care
Opportunities for Savings in Risk Arrangements for Oncologic Care Open
Importance As the US accelerates adoption of alternative payment through global payment models such as Accountable Care Organizations (ACOs) or Medicare Advantage (MA), high spending for cancer care is a potential target for savings. Objec…
View article: Organization of Cancer Specialists in US Physician Practices and Health Systems
Organization of Cancer Specialists in US Physician Practices and Health Systems Open
PURPOSE To describe the supply of cancer specialists, the organization of cancer care within versus outside of health systems, and the distance to multispecialty cancer centers. METHODS Using the 2018 Health Systems and Provider Database f…
View article: Practice-Level Variation in Molecular Testing and Use of Targeted Therapy for Patients With Non–Small Cell Lung Cancer and Colorectal Cancer
Practice-Level Variation in Molecular Testing and Use of Targeted Therapy for Patients With Non–Small Cell Lung Cancer and Colorectal Cancer Open
Importance All patients with newly diagnosed non–small cell lung cancer (NSCLC) and colorectal cancer (CRC) should receive molecular testing to identify those who can benefit from targeted therapies. However, many patients do not receive r…
View article: Validation of an open-source smartphone step counting algorithm in clinical and non-clinical settings
Validation of an open-source smartphone step counting algorithm in clinical and non-clinical settings Open
Background Step counts are increasingly used in public health and clinical research to assess wellbeing, lifestyle, and health status. However, estimating step counts using commercial activity trackers has several limitations, including a …
View article: Open-Source, Step-Counting Algorithm for Smartphone Data Collected in Clinical and Nonclinical Settings: Algorithm Development and Validation Study (Preprint)
Open-Source, Step-Counting Algorithm for Smartphone Data Collected in Clinical and Nonclinical Settings: Algorithm Development and Validation Study (Preprint) Open
BACKGROUND Step counts are increasingly used in public health and clinical research to assess well-being, lifestyle, and health status. However, estimating step counts using commercial activity trackers has several limitations, including …
View article: Racial and Ethnic Disparities in Opioid Access and Urine Drug Screening Among Older Patients With Poor-Prognosis Cancer Near the End of Life
Racial and Ethnic Disparities in Opioid Access and Urine Drug Screening Among Older Patients With Poor-Prognosis Cancer Near the End of Life Open
PURPOSE To characterize racial and ethnic disparities and trends in opioid access and urine drug screening (UDS) among patients dying of cancer, and to explore potential mechanisms. METHODS Among 318,549 non-Hispanic White (White), Black, …
View article: Adoption of Innovative Therapies Across Oncology Practices—Evidence From Immunotherapy
Adoption of Innovative Therapies Across Oncology Practices—Evidence From Immunotherapy Open
Importance Immunotherapies reflect an important breakthrough in cancer treatment, substantially improving outcomes for patients with a variety of cancer types, yet little is known about which practices have adopted this novel therapy or th…
View article: Predicting 180-day mortality for women with ovarian cancer using machine learning and patient-reported outcome data
Predicting 180-day mortality for women with ovarian cancer using machine learning and patient-reported outcome data Open
Contrary to national guidelines, women with ovarian cancer often receive treatment at the end of life, potentially due to the difficulty in accurately estimating prognosis. We trained machine learning algorithms to guide prognosis by predi…
View article: TP015/#1566 A phase 2, two-stage, study of mirvetuximab soravtansine (IMGN853) in combination with pembrolizumab in patients with microsatellite stable (MSS) recurrent or persistent endometrial cancer (EC)
TP015/#1566 A phase 2, two-stage, study of mirvetuximab soravtansine (IMGN853) in combination with pembrolizumab in patients with microsatellite stable (MSS) recurrent or persistent endometrial cancer (EC) Open
Objectives Folate receptor-alpha (FRα) expression is associated with poor prognosis in endometrial cancer (EC). Mirvetuximab soravtansine (MIRV), an antibody drug conjugate (ADC) comprising a FRα-binding antibody, cleavable linker, and the…
View article: Racial and ethnic disparities in cancer caregiver burden and potential sociocultural mediators
Racial and ethnic disparities in cancer caregiver burden and potential sociocultural mediators Open
Purpose Black and Hispanic cancer patients experience many worse care quality and health outcomes than non-Hispanic White patients, yet less is known about disparities in caregiving responsibilities and burden among cancer caregivers. Meth…
View article: Racial and ethnic disparities in cancer caregiver burden and potential sociocultural mediators
Racial and ethnic disparities in cancer caregiver burden and potential sociocultural mediators Open
Purpose Black and Hispanic cancer patients experience many worse care quality and health outcomes than non-Hispanic White patients, yet less is known about disparities in caregiving responsibilities and burden among cancer caregivers. Meth…
View article: Cancer Caregivers’ Prognostic and End-of-Life Communication Needs and Experiences and their Impact
Cancer Caregivers’ Prognostic and End-of-Life Communication Needs and Experiences and their Impact Open
View article: Evaluation of Treatment With Talazoparib and Avelumab in Patients With Recurrent Mismatch Repair Proficient Endometrial Cancer
Evaluation of Treatment With Talazoparib and Avelumab in Patients With Recurrent Mismatch Repair Proficient Endometrial Cancer Open
Importance Although the activity of pembrolizumab and lenvatinib (the only US Food and Drug Administration–approved immunotherapy for mismatch repair proficient endometrial cancer [MMRP EC]) is compelling, there are no biomarkers of respon…