Explanipedia

Predictive value of Shanghai score system in patients with drug-induced type 1 Brugada electrocardiographic pattern Open

Vincenzo Russo, Alfredo Caturano, Federico Migliore, Federico Guerra, Pietro Francia , et al. · 2025

Background The Shanghai score system was developed to enhance the risk stratification in Brugada Syndrome (BrS); however, its prognostic value in drug-induced type 1 BrS remains unclear. Methods This study involved 698 patients with drug-i…

305 | RADIATION THERAPY ON SINGLE RESIDUAL PET POSITIVE LESIONS AFTER FRONTLINE CHEMIOIMMUNOTHERAPY IN DIFFUSE LARGE B CELL LYMPHOMA: A SINGLE CENTER RETROSPECTIVE ANALYSIS Open

Francesco Ballardini, Stefania Ferrari, Monica Rondi, F. Filippone, Roberta Muni , et al. · 2025

568 | REAL‐WORLD DATA ANALYSIS WITH INFORMATICS FOR INTEGRATING BIOLOGY AND THE BEDSIDE (I2B2): A RELIABLE TOOL FOR EVIDENCE GENERATION IN FOLLICULAR LYMPHOMA Open

Giuseppe Gritti, Stefania Ferrari, Anna Maria Barbui, Andrea Rossi, Monica Rondi , et al. · 2025

Regional differences in the right ventricular activation and repolarization patterns between Brugada patients and controls Open

Paolo Seghetti, S Latrofa, V Hartwig, Martina Nesti, Gernot Plank , et al. · 2025

Background Brugada Syndrome (BrS) is an electrophysiological disorder affecting the right ventricular outflow tract (RVOT). The two leading theories of BrS pathophysiology suggest that arrhythmogenesis arises from either repolarization or …

Electrophysiological patterns and structural substrates of Brugada syndrome: Critical appraisal and computational analyses Open

Paolo Seghetti, S Latrofa, Niccolò Biasi, Alberto Giannoni, Valentina Hartwig , et al. · 2024

Brugada syndrome (BrS) is a cardiac electrophysiological disease with unknown etiology, associated with sudden cardiac death. Symptomatic patients are treated with implanted cardiac defibrillator, but no risk stratification strategy is eff…

Unraveling the Enigma of Moderate Aortic Stenosis: Challenges and Future Prospects Open

Gloria Santangelo, Gabriele Tumminello, Lucia Barbieri, G Mallardi, Andrea Faggiano , et al. · 2024

According to current guidelines, only clinical surveillance is recommended for patients with moderate aortic valve stenosis (AS), while aortic valve replacement may be considered in patients undergoing surgery for other indications. Recent…

Atrial voltage analysis following vein of marshall alcohol infusion predicts mitral line block Open

Simone Taddeucci, S Garibaldi, Martina Nesti, Gianluca Mirizzi, Umberto Startari , et al. · 2024

Background The vein of Marshall (VOM) is a promising therapeutic target for the atrial fibrillation (AF) treatment, fitting perfectly with the "Coumel triangle" as it contains triggers of focal activities and stable reentries, autonomic pa…

miRNAs as a tool for the diagnosis of suspected Brugada Syndrome Open

Manuela Cabiati, Elisa Persiani, Silvia Del Ry, Marcello Piacenti, Andrea Rossi , et al. · 2024

Background/Introduction Brugada syndrome (BrS) is a life-threatening arrhythmogenic disease that can lead to sudden unexplained death/cardiac arrest in otherwise healthy individuals. ECG represents the gold standard for the diagnosis. In 3…

Acute impact of vein of marshall ethanol infusion combined with anatomical ablation validated by pacing in redo ablation of persistent atrial fibrillation Open

Martina Nesti, Andrea Rossi, S Garibaldi, Luca Panchetti, Gianluca Mirizzi , et al. · 2024

Background Catheter ablation with radiofrequency in persistent atrial fibrillation (PeAF) has limited success and a significant proportion of patients requires redo ablation. Several trials showed that addition of vein of Marshall ethanol …

ATRIAL VOLTAGE ANALYSIS FOLLOWING VEIN OF MARSHALL ETHANOL INFUSION PREDICTS MITRAL LINE BLOCK Open

Simone Taddeucci, S Garibaldi, Martina Nesti, Federico Landra, Umberto Startari , et al. · 2024

Background The vein of Marshall (VoM) is a promising target for atrial fibrillation (AF) treatment, matching with the ‘Coumel triangle‘ by housing triggers, autonomic connections, and serving as a substrate for perimitral flutters. Lateral…

Endocardial repolarization dispersion in BrS: A novel automatic algorithm for mapping activation recovery interval Open

S Latrofa, Valentina Hartwig, Lorenzo Bachi, Pasquale Notarstefano, S Garibaldi , et al. · 2024

Introduction Repolarization dispersion in the right ventricular outflow tract (RVOT) contributes to the type‐1 electrocardiographic (ECG) phenotype of Brugada syndrome (BrS), while data on the significance and feasibility of mapping repola…

A proposed index of myocardial staining for vein of Marshall ethanol infusion: an Italian single-center experience Open

Federico Landra, Martina Nesti, S Garibaldi, Gianluca Mirizzi, Umberto Startari , et al. · 2024

Identification of the Arrhythmogenic Substrate in Brugada Syndrome: A Computational Study Open

Paolo Seghetti, Niccolò Biasi, Matteo Mercati, Valentina Hartwig, Andrea Rossi , et al. · 2024

Sensitivity and Specificity of Transthoracic Echocardiography in Diagnosing the Presence of the Anomalous Origin of Left Circumflex Coronary Artery From the Right Sinus of Valsalva in an Adult Population Open

Stefano Bonapace, Laura Lanzoni, Andrea Rossi, Carmelo Cicciò, Mariantonietta Cicoira , et al. · 2023

Baseline‐PET derived metrics are the most relevant factors for risk stratification in early‐stage nonbulky HL: preliminary results of the RAFTING trial Open

Jan Maciej Zaucha, Marco Picardi, Michał Kurlapski, Caterina Patti, Eva Domingo‐Doménech , et al. · 2023

Introduction: The efficacy of combined-modality treatment (Tx) with chemotherapy (CT) and radiotherapy (RT) in early-stage Hodgkin Lymphoma (eHL) is offset by long-term morbidity, with a cumulative incidence of 2nd primary malignancy at 40…

Left atrial strain predicts outcome in cardiovascular diseases: a systematic review and meta-analysis Open

Francesca Rizzetto, Caterina Maffeis, A. Mandurino-Mirizzi, Annalisa De Silvestri, Stefano Ghio , et al. · 2023

Funding Acknowledgements Type of funding sources: None. Aims The prognostic role of left atrial volume is well established in a variety of cardiovascular conditions but left atrial enlargement may occur at a relatively advanced stage of di…

A novel workflow for advanced mapping of repolarization dispersion from endocardial unipolar electrograms in patients with coved-type brugada syndrome Open

S Latrofa, S Garibaldi, Shaiana Vilella Hartwig, Luca Panchetti, M S Morelli , et al. · 2023

Funding Acknowledgements Type of funding sources: None. Background Accentuation of the action potential notch in the epicardium causes the prolongation of the epicardial action potentials in the right ventricular outflow tract (RVOT) and i…

C46 ELECTROPHYSIOLOGICAL ASSESSMENT OF ATRIAL TACHYCARDIA SUBSTRATES IN PATIENTS WITH REPAIRED TETRALOGY OF FALLOT Open

Gianluca Mirizzi, S Garibaldi, Umberto Startari, Andrea Rossi, Luca Panchetti , et al. · 2023

Introduction Adults with repaired tetralogy of Fallot (rToF) experience episodes of atrial tachycardia (AT) and radiofrequency catheter ablation (RFCA) is often required but systematic evaluation of the mechanisms and recurrences is lackin…

P162 ARRHYTHMIC MITRAL VALVE PROLAPSE OCCURRING AS ABORTED SUDDEN CARDIAC DEATH Open

Antonino Maria Quintilio Alberio, S Garibaldi, Gianluca Mirizzi, Massimo Piergiuseppe Franchi, Cecilia Viacava , et al. · 2023

Mitral valve prolapse (MVP) is the common valvular heart disease, with a prevalence about 1–3% in the population. MVP is characterized on echocardiography by an abnormal systolic displacement of mitral valve leaflets into left atrium (LA) …

Role of Rituximab Addition to First-line Chemotherapy Regimens in Nodular Lymphocyte-predominant Hodgkin Lymphoma: A Study by Fondazione Italiana Linfomi Open

Manuel Gotti, Roberta Sciarra, Alessandro Pulsoni, Francesco Merli, Stefano Luminari , et al. · 2023

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare entity whose neoplastic cells retain a B-cell phenotype with expression of CD20. Radiotherapy is recommended for favorable stage IA disease while for other stages guidelines…

Left Atrial Strain in the Assessment of Diastolic Function in Heart Failure: A Machine Learning Approach Open

Erberto Carluccio, Matteo Cameli, Andrea Rossi, Frank Lloyd Dini, Paolo Biagioli , et al. · 2023

Background: Diastolic dysfunction (DD) assessment in heart failure is still challenging. Peak atrial longitudinal strain (PALS) is strongly related to end-diastolic pressure and prognosis, but it is still not part of standard DD assessment…

1038 RIGHT VENTRICULAR-PULMONARY ARTERIAL (UN)COUPLING ESTIMATION IN PATIENTS WITH TRICUSPID REGURGITATION Open

Manuela Iseppi, Lorenzo Niro, Elvin Tafciu, Caterina Maffeis, Giovanni Benfari , et al. · 2022

Background right-ventricular (RV)-pulmonary arterial (PA) uncoupling expressed by Tricuspid Annular Plane Systolic Excursion (TAPSE)/Pulmonary Artery Systolic Pressure (PAPs) ratio is associated with poor outcomes in patients with heart fa…

897 PEAK RIGHT ATRIAL LONGITUDINAL STRAIN: A NEW PARAMETER IN PREDICTING VENOUS CONGESTION Open

Lorenzo Niro, Manuela Iseppi, Diego Fanti, Caterina Maffeis, Corinna Bergamini , et al. · 2022

Background tricuspid regurgitation (TR) of either organic or functional etiology can lead to systemic venous congestion particularly in its more severe forms. Little is known about the role of the right atrium (RA) which acts as an interme…

501 CASEOUS CALCIFICATION OF THE MITRAL ANNULUS AND THE IMPORTANCE OF ITS IDENTIFICATION IN THE CLINICAL PRACTICE: A REPRESENTATIVE CASE Open

Luca Ciceri, Paolo Springhetti, Alberto Dotto, Caterina Maffeis, Elvin Tafciu , et al. · 2022

1. Introduction Caseous Calcification of the Mitral Annulus (CCMA) is a rare condition characterized by a liquefaction degeneration that usually involves posterior mitral ring and it is considered a variant of mitral annulus calcification.…

1082 LEFT VENTRICULAR FUNCTION ESTIMATION: WHEN VOLUMES MEASUREMENT IS NOT FEASIBLE Open

Sara Pazzi, Laura Bariselli Maffignoli, Gabriele Bertani, Corinna Bergamini, Monica Pegoretti , et al. · 2022

Background Contrast echocardiography is mainly performed for the assessment of global left ventricular (LV) function, left ventricular ejection fraction (LVEF) and stroke volume (SV) thanks to improved visualization of endocardial LV borde…

224 RIGHT VENTRICULAR MECHANICS AND THE CLINICAL IMPLICATION OF 2D SPECKLE TRACKING ASSESSMENT IN SEVERE AORTIC STENOSIS Open

Paolo Springhetti, Luca Ciceri, G Urbani, Alberto Dotto, Caterina Maffeis , et al. · 2022

Introduction The prognostic role of RV function assessment in severe AS has been demonstrated in previous studies. However, the role of 2D speckle tracking RV evaluation in the context of severe AS has not been completely clarified. Method…

608 PEAK ATRIAL SYSTOLIC LONGITUDINAL STRAIN (PALS) AS AN EARLY PARAMETER OF CANCER THERAPY-RELATED CARDIAC DYSFUNCTION Open

Ilaria Minnucci, Corinna Bergamini, Lorenzo Niro, Paolo Springhetti, Laura Trento , et al. · 2022

Background Trastuzumab (TZ) is widely used for his key role in HER2 positive breast cancer. However, the most concerning cardiovascular complication is cardiotoxicity. Many studies have highlighted the importance of screening for subclinic…

218 PERSISTENT LEFT SUPERIOR VENA CAVA IN AN ADULT PATIENT WITH AN IMPLANTED PACEMAKER: A CASE REPORT Open

A Varriale, Chiara Nannelli, Paolo Springhetti, Andrea Rossi, Corinna Bergamini , et al. · 2022

Introduction Persistent left superior vena cava (PLSVC) is the most common thoracic venous anomaly, although infrequent in the general population (prevalence estimates as 0.2-3%). It begins at the junction of the left subclavian and intern…

1000 THE EFFECT OF RIGHT VENTRICULAR SIZE AND FUNCTION ON TRICUSPID REGURGITATION SEVERITY Open

Lorenzo Niro, Manuela Iseppi, Elvin Tafciu, Caterina Maffeis, Corinna Bergamini , et al. · 2022

Background Tricuspid regurgitation (TR) is a relatively common echocardiographic finding and its proportional influence on prognosis and quality of life has been well described. A bidirectional relationship connects TR severity and its vol…

146 AORTIC ACCELERATION TIME/EJECTION TIME RATIO AND BI-VENTRICULAR PERFORMANCE IN SEVERE AORTIC STENOSIS Open

Alberto Dotto, Luca Ciceri, Paolo Springhetti, G Urbani, Paolo Alberto Del Sole , et al. · 2022

Introduction Echocardiographic evaluation of severe aortic stenosis (SAS) is is important to guide the therapeutic approach but often challenging. Recent studies have demonstrated that the ratio of acceleration time/ejection time (AT/ET) i…

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