Alexis Fay
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View article: A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice
A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice Open
Iron plays a major role in the deterioration of β-thalassemia. Indeed, the high levels of transferrin saturation and iron delivered to erythroid progenitors are associated with production of α-globin precipitates that negatively affect ery…
View article: PI3KCIIα-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice
PI3KCIIα-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice Open
BACKGROUND: The ability to respond to mechanical forces is a basic requirement for maintaining endothelial cell (ECs) homeostasis, which is continuously subjected to low shear stress (LSS) and high shear stress (HSS). In arteries, LSS and …
View article: LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA
LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA Open
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View article: Distribution spatiale et mobilité du phosphore sédimentaire dans une retenue hydroélectrique
Distribution spatiale et mobilité du phosphore sédimentaire dans une retenue hydroélectrique Open
Malgré la réduction des rejets de phosphore (P) dans l’environnement, les efflorescences phytoplanctoniques sont toujours observées dans un grand nombre de masses d’eau. C’est notamment le cas dans les retenues de barrage où la perturbatio…