Alfonso Grimaldi
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View article: Diagnostic Value of JC Polyomavirus Viruria, Viremia, Serostatus and microRNA Expression in Multiple Sclerosis Patients Undergoing Immunosuppressive Treatment
Diagnostic Value of JC Polyomavirus Viruria, Viremia, Serostatus and microRNA Expression in Multiple Sclerosis Patients Undergoing Immunosuppressive Treatment Open
Markers of JC polyomavirus (JCPyV) activity can be used to evaluate the risk of progressive multifocal leukoencephalopathy (PML) in treated multiple sclerosis (MS) patients. The presence of JCPyV DNA and microRNA (miR-J1-5p), the anti-JCV …
View article: Microglia control glutamatergic synapses in the adult mouse hippocampus
Microglia control glutamatergic synapses in the adult mouse hippocampus Open
Microglia cells are active players in regulating synaptic development and plasticity in the brain. However, how they influence the normal functioning of synapses is largely unknown. In this study, we characterized the effects of pharmacolo…
View article: Antibiotics Treatment Modulates Microglia–Synapses Interaction
Antibiotics Treatment Modulates Microglia–Synapses Interaction Open
‘Dysbiosis’ of the adult gut microbiota, in response to challenges such as infection, altered diet, stress, and antibiotics treatment has been recently linked to pathological alteration of brain function and behavior. Moreover, gut microbi…
View article: Risk Assessment of Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis Patients during 1 Year of Ocrelizumab Treatment
Risk Assessment of Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis Patients during 1 Year of Ocrelizumab Treatment Open
Background: Progressive multifocal leukoencephalopathy (PML) caused by the JC virus is the main limitation to the use of disease modifying therapies for treatment of multiple sclerosis (MS). Methods: To assess the PML risk in course of ocr…
View article: The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca<sup>2+</sup>‐activated K<sub>Ca</sub>3.1 channels
The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca<sup>2+</sup>‐activated K<sub>Ca</sub>3.1 channels Open
Background and Purpose Amyotrophic lateral sclerosis (ALS) patients exhibit dysfunctional energy metabolism and weight loss, which is negatively correlated with survival, together with neuroinflammation. However, the possible contribution …
View article: Antibiotics Treatment Modulates Microglia-Synapses Interaction Through CX3CL1/CX3CR1 Axis
Antibiotics Treatment Modulates Microglia-Synapses Interaction Through CX3CL1/CX3CR1 Axis Open
‘Dysbiosis’ of the adult gut microbiota, in response to challenges such as infection, altered diet, stress, and antibiotics treatment has been recently linked to pathological alteration of brain func-tion and behavior. Moreover…
View article: Patient’s point of view on the use of telemedicine in multiple sclerosis: a web-based survey
Patient’s point of view on the use of telemedicine in multiple sclerosis: a web-based survey Open
Restrictions in the access to healthcare facilities during COVID-19 pandemic have raised the need for remote monitoring of chronic medical conditions, including multiple sclerosis (MS). In order to enable the continuity of care in these ci…
View article: Microglia control glutamatergic synapses in the adult mouse hippocampus
Microglia control glutamatergic synapses in the adult mouse hippocampus Open
Microglial cells are active players in regulating synaptic development and plasticity in the brain. However, how these cells influence the normal functioning of synapses is largely unknown. In this study, we characterized the effects of ph…
View article: Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer’s Disease Patients, Possible Biomarkers for Early Diagnosis
Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer’s Disease Patients, Possible Biomarkers for Early Diagnosis Open
Alzheimer's disease (AD), a primary cause of dementia in the aging population, is characterized by extracellular amyloid-beta peptides aggregation, intracellular deposits of hyperphosphorylated tau, neurodegeneration and glial activation i…
View article: Microglia-Derived Microvesicles Affect Microglia Phenotype in Glioma
Microglia-Derived Microvesicles Affect Microglia Phenotype in Glioma Open
Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic ac…
View article: Microglia shape presynaptic properties at developing glutamatergic synapses
Microglia shape presynaptic properties at developing glutamatergic synapses Open
Deficient neuron–microglia signaling during brain development is associated with abnormal synaptic maturation. However, the precise impact of deficient microglia function on synaptic maturation and the mechanisms involved remain poorly def…
View article: Scattering-assisted localization microscopy
Scattering-assisted localization microscopy Open
Super-resolution fluoresce microscopy techniques break the diffraction limit in biological systems, promising a resolution ultimately limited only by the size of the emitting molecules. These methods, however, demand high numerical apertur…
View article: Scattering Assisted Imaging
Scattering Assisted Imaging Open
An ideal imaging system provides a spatial resolution that is ultimately dictated by the numerical aperture (NA) of the illumination and collection optics. In biological tissue, resolution is further affected by scattering limiting the pen…
View article: Mycolactone displays anti-inflammatory effects on the nervous system
Mycolactone displays anti-inflammatory effects on the nervous system Open
The present study provides in vitro and in vivo evidence that mycolactone suppresses the inflammatory responses of sensory neurons, Schwann cells and microglia, without affecting the cell viability. Together with previous studies using per…
View article: The Glycoside Oleandrin Reduces Glioma Growth with Direct and Indirect Effects on Tumor Cells
The Glycoside Oleandrin Reduces Glioma Growth with Direct and Indirect Effects on Tumor Cells Open
Oleandrin is a glycoside that inhibits the ubiquitous enzyme Na + /K + -ATPase. In addition to its known effects on cardiac muscle, recent in vitro and in vivo evidence highlighted its potential for anticancer properties. Here, we evaluate…
View article: Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells
Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells Open
Glioblastoma cells feature mammalian target of rapamycin (mTOR) up-regulation which relates to a variety of effects such as: lower survival, higher infiltration, high stemness and radio- and chemo-resistance. Recently, it was demonstrated …
View article: KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment
KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment Open
Malignant gliomas are among the most frequent and aggressive cerebral tumors, characterized by high proliferative and invasive indexes. Standard therapy for patients, after surgery and radiotherapy, consists of temozolomide (TMZ), a methyl…