Alfonso Méndez-Tenorio
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View article: Description of the Distinctive Changes in the Colonic Microbiome Associated with Irritable Bowel Syndrome, Uncomplicated Diverticulitis, and Tubular Adenoma
Description of the Distinctive Changes in the Colonic Microbiome Associated with Irritable Bowel Syndrome, Uncomplicated Diverticulitis, and Tubular Adenoma Open
Background: The pathogenesis of various colon-related pathologies, including irritable bowel syndrome, uncomplicated diverticulitis, and tubular adenoma, remains unknown, primarily due to their multifactorial nature. These gastrointestinal…
View article: Deep Sequencing Reveals Novel Mutations in Androgen Receptor-Related Genes in Prostate Cancer
Deep Sequencing Reveals Novel Mutations in Androgen Receptor-Related Genes in Prostate Cancer Open
Prostate cancer (PCa) is the second most frequent tumor and the fifth leading cause of cancer-related death in men worldwide. PCa shows the largest clinical disparities across Asian, Caucasian, and African descendants among all cancer type…
View article: Análisis del pangenoma en Azospirillum brasilense
Análisis del pangenoma en Azospirillum brasilense Open
La bacteria Azospirillum brasilense ha sido estudiada por asociarse a la estimulación de crecimiento de plantas por producción de auxinas, especialmente del ácido indol acético, además de la fijación biológica de nitrógeno. El análisis de …
View article: CagY sequence and structural motifs are associated with ancestry and disease in world-wide<i>Helicobacter pylori</i>strains
CagY sequence and structural motifs are associated with ancestry and disease in world-wide<i>Helicobacter pylori</i>strains Open
Helicobacter pylori ( Hp ) interacts with gastric epithelial cells using a multi-protein type 4 secretion system (T4SS) whose function is regulated by CagY. CagY is the T4SS backbone, connecting the bacterial cytoplasm with the epithelial …
View article: Gene Expression Profile of Cultured Human Coronary Arterial Endothelial Cells Exposed to Serum from Chronic Kidney Disease Patients: Role of MAPK Signaling Pathway
Gene Expression Profile of Cultured Human Coronary Arterial Endothelial Cells Exposed to Serum from Chronic Kidney Disease Patients: Role of MAPK Signaling Pathway Open
Patients with end-stage renal disease (ESRD) are at increased risk of cardiovascular disease (CVD), such as myocardial infarction (MI). Uremic toxins and endothelial dysfunction are central to this process. In this exploratory study, we us…
View article: Exploring Marine Natural Compounds: Innovative Therapeutic Candidates Against Chagas Disease Through Virtual Screening and Molecular Dynamics
Exploring Marine Natural Compounds: Innovative Therapeutic Candidates Against Chagas Disease Through Virtual Screening and Molecular Dynamics Open
Chagas disease, caused by the protozoan Trypanosoma cruzi, represents a significant public health challenge, particularly in Latin America’s endemic regions. The limited efficacy and frequent adverse effects of current treatments underscor…
View article: Genome-Wide Identification and Characterization of SNPs and InDels of Capsicum annuum var. glabriusculum from Mexico Based on Whole Genome Sequencing
Genome-Wide Identification and Characterization of SNPs and InDels of Capsicum annuum var. glabriusculum from Mexico Based on Whole Genome Sequencing Open
Capsicum annuum var. glabriusculum is an economically important horticultural crop and is considered the wild genetic ancestor of chili peppers. The distribution range extends from southern North America, through Central America, to South …
View article: Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Targeted Therapy in Lung Adenocarcinoma Cell Lines
Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Targeted Therapy in Lung Adenocarcinoma Cell Lines Open
Lung adenocarcinoma is the most prevalent form of lung cancer, and drug resistance poses a significant obstacle in its treatment. This study aimed to investigate the overexpression of long non-coding RNAs (lncRNAs) as a mechanism that prom…
View article: Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Target Therapy in Lung Adenocarcinoma Cell Lines
Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Target Therapy in Lung Adenocarcinoma Cell Lines Open
Lung adenocarcinoma is the most prevalent form of lung cancer, and drug resistance is a significant obstacle in its treatment. This study aimed to investigate the overexpression of long non-coding RNAs (lncRNAs) as a mechanism that promote…
View article: A Proposal for a Consolidated Structural Model of the CagY Protein of Helicobacter pylori
A Proposal for a Consolidated Structural Model of the CagY Protein of Helicobacter pylori Open
CagY is the largest and most complex protein from Helicobacter pylori’s (Hp) type IV secretion system (T4SS), playing a critical role in the modulation of gastric inflammation and risk for gastric cancer. CagY spans from the inner to the o…
View article: A Proposal for a Consolidated Structural Model of the CagY Protein of Helicobacter pylori
A Proposal for a Consolidated Structural Model of the CagY Protein of Helicobacter pylori Open
CagY is the largest and most complex protein from Helicobacter pylori's type IV secretion system (T4SS) and may participate in the modulation of gastric tissue inflammation. A three-dimensional structure has been reported for only two segm…
View article: Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma
Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma Open
Resistance to cisplatin is the main cause of treatment failure in lung adenocarcinoma. Drug-tolerant-persister (DTP) cells are responsible for intrinsic resistance, since they survive the initial cycles of treatment, representing a reservo…
View article: Bioinformatics analysis of GPCRs: A window into breast tumorigenesis and metastasis
Bioinformatics analysis of GPCRs: A window into breast tumorigenesis and metastasis Open
G-protein-coupled receptors (GPCRs) are known signal transducers and are increasingly implicated in tumorigenesis, but their precise roles in breast cancer progression remain underexplored. We scrutinized the mRNA expression profiles of fi…
View article: Phylogenetic origin of Helicobacter pylori pathogenicity island and risk of stomach cancer and high-grade premalignant gastric lesions
Phylogenetic origin of Helicobacter pylori pathogenicity island and risk of stomach cancer and high-grade premalignant gastric lesions Open
Infection by Helicobacter pylori (Hp) has been causally linked to risk of gastric cancer (GC). The coevolution of Hp and humans shaped the risk of GC as our species left Africa and migrated to the other continents. Latin America (LatAm) is…
View article: In Silico Identification and Characterization of circRNAs as Potential Virulence-Related miRNA/siRNA Sponges from Entamoeba histolytica and Encystment-Related circRNAs from Entamoeba invadens
In Silico Identification and Characterization of circRNAs as Potential Virulence-Related miRNA/siRNA Sponges from Entamoeba histolytica and Encystment-Related circRNAs from Entamoeba invadens Open
Ubiquitous eukaryotic non-coding circular RNAs regulate transcription and translation. We have reported full-length intronic circular RNAs (flicRNAs) in Entamoeba histolytica with esterified 3′ss and 5′ss. Their 5′ss GU-rich elements are e…
View article: Herpesvirus Screening in Childhood Hematopoietic Transplant Reveals High Systemic Inflammation in Episodes of Multiple Viral Detection and an EBV Association with Elevated IL-1β, IL-8 and Graft-Versus-Host Disease
Herpesvirus Screening in Childhood Hematopoietic Transplant Reveals High Systemic Inflammation in Episodes of Multiple Viral Detection and an EBV Association with Elevated IL-1β, IL-8 and Graft-Versus-Host Disease Open
Infections remain a major cause of morbidity and mortality among hematopoietic stem cell transplant (HSCT) recipients. Unlike Epstein–Barr Virus (EBV) and Human Cytomegalovirus (HCMV), Human Herpesvirus (HHV) 6, HHV7 and HHV8 are not routi…
View article: The Lack of the TetR-Like Repressor Gene BCG_2177c (Rv2160A) May Help Mycobacteria Overcome Intracellular Redox Stress and Survive Longer Inside Macrophages When Surrounded by a Lipid Environment
The Lack of the TetR-Like Repressor Gene BCG_2177c (Rv2160A) May Help Mycobacteria Overcome Intracellular Redox Stress and Survive Longer Inside Macrophages When Surrounded by a Lipid Environment Open
Mycobacteria, like other microorganisms, survive under different environmental variations by expressing an efficient adaptive response, oriented by regulatory elements, such as transcriptional repressors of the TetR family. These repressor…
View article: A Novel Adult Murine Model of Typical Enteroaggregative Escherichia coli Infection Reveals Microbiota Dysbiosis, Mucus Secretion, and AAF/II-Mediated Expression and Localization of β-Catenin and Expression of MUC1 in Ileum
A Novel Adult Murine Model of Typical Enteroaggregative Escherichia coli Infection Reveals Microbiota Dysbiosis, Mucus Secretion, and AAF/II-Mediated Expression and Localization of β-Catenin and Expression of MUC1 in Ileum Open
Typical enteroaggregative Escherichia coli (tEAEC) is a diarrheagenic E. coli pathotype associated with pediatric and traveler’s diarrhea. Even without diarrhea, EAEC infections in children also lead to increased gut inflammation and growt…
View article: Global expression profiling of CD10 + /CD19 + pre-B lymphoblasts from Hispanic B-ALL patients correlates with comparative TARGET database analysis
Global expression profiling of CD10 + /CD19 + pre-B lymphoblasts from Hispanic B-ALL patients correlates with comparative TARGET database analysis Open
View article: Characterization and identification of lactic acid bacteria from Mexican stingless bees (Apidae: Meliponini)
Characterization and identification of lactic acid bacteria from Mexican stingless bees (Apidae: Meliponini) Open
Stingless bees (family Apidae; tribe Meliponini), native from Mexico, are essential in tropical ecosystems. They are responsible for the pollination of many crops, native flora, and honey production. Lactic Acid Bacteria (LAB) are a regula…
View article: Whole Genome Sequencing of Pediatric Klebsiella pneumoniae Strains Reveals Important Insights Into Their Virulence-Associated Traits
Whole Genome Sequencing of Pediatric Klebsiella pneumoniae Strains Reveals Important Insights Into Their Virulence-Associated Traits Open
Klebsiella pneumoniae is recognized as a common cause of nosocomial infections and outbreaks causing pneumonia, septicemia, and urinary tract infections. This opportunistic bacterium shows an increasing acquisition of antibiotic-resistance…
View article: Analyses of publicly available <i>Hungatella hathewayi</i> genomes revealed genetic distances indicating they belong to more than one species
Analyses of publicly available <i>Hungatella hathewayi</i> genomes revealed genetic distances indicating they belong to more than one species Open
Hungatella hathewayi has been observed to be a member of the gut microbiome. Unfortunately, little is known about this organism in spite of being associated with human fatalities; it is important to understand virulence mechanisms a…
View article: Gene Expression Profile of HCAEC Cells Exposed to Serum From Chronic Kidney Disease Patients: Role of MAPK Signaling Pathway
Gene Expression Profile of HCAEC Cells Exposed to Serum From Chronic Kidney Disease Patients: Role of MAPK Signaling Pathway Open
End-stage renal disease (ESRD) patients have an elevated risk of cardiovascular (CV) complications including acute myocardial infarction (AMI); endothelial dysfunction and accumulation of uremic toxins have been associated with such CV-eve…
View article: Claudin-Low Breast Cancer Inflammatory Signatures Support Polarization of M1-Like Macrophages with Protumoral Activity
Claudin-Low Breast Cancer Inflammatory Signatures Support Polarization of M1-Like Macrophages with Protumoral Activity Open
We previously reported that triple-negative breast cancer (BRCA) cells overexpress the cytokines GM-CSF, G-CSF, MCP-1, and RANTES, and when monocytes were 3-D co-cultured with them, M1-like macrophages were generated with the ability to in…
View article: A 500-year tale of co-evolution, adaptation, and virulence: <i>Helicobacter pylori</i> in the Americas
A 500-year tale of co-evolution, adaptation, and virulence: <i>Helicobacter pylori</i> in the Americas Open
Helicobacter pylori is a common component of the human stomach microbiota, possibly dating back to the speciation of Homo sapiens. A history of pathogen evolution in allopatry has led to the development of genetically distinct H. pylori su…
View article: Enhanced Antigiardial Effect of Omeprazole Analog Benzimidazole Compounds
Enhanced Antigiardial Effect of Omeprazole Analog Benzimidazole Compounds Open
Giardiasis is a diarrheal disease that is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; however, failures in drug therapy are common, and have adverse effects and increased res…
View article: Phylogeny, evolution, and potential ecological relationship of cytochrome CYP52 enzymes in Saccharomycetales yeasts
Phylogeny, evolution, and potential ecological relationship of cytochrome CYP52 enzymes in Saccharomycetales yeasts Open
View article: Genetic polymorphisms in the cag pathogenicity island of <i>Helicobacter pylori</i> and risk of stomach cancer and high‐grade premalignant gastric lesions
Genetic polymorphisms in the cag pathogenicity island of <i>Helicobacter pylori</i> and risk of stomach cancer and high‐grade premalignant gastric lesions Open
Helicobacter pylori (Hp) infects the stomach of about half of the human population and is strongly associated with the risk of gastric cancer (GC) and its premalignant precursors. The cag pathogenicity island (cagPAI) is a region of the Hp…
View article: Variations in cag pathogenicity island genes of Helicobacter pylori from Latin American groups may influence neoplastic progression to gastric cancer
Variations in cag pathogenicity island genes of Helicobacter pylori from Latin American groups may influence neoplastic progression to gastric cancer Open
View article: Prediction of Structure and Molecular Interaction with DNA of BvrR, a Virulence-Associated Regulatory Protein of Brucella
Prediction of Structure and Molecular Interaction with DNA of BvrR, a Virulence-Associated Regulatory Protein of Brucella Open
Brucellosis, also known as “undulant fever” is a zoonotic disease caused by Brucella, which is a facultative intracellular bacterium. Despite efforts to eradicate this disease, infection in uncontrolled domestic animals persists in several…