Alfred C. Aplin
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View article: Role of the Pancreatic Islet Microvasculature in Health and Disease
Role of the Pancreatic Islet Microvasculature in Health and Disease Open
The pancreatic islet vasculature comprises microvascular endothelial cells surrounded by mural cells (pericytes). Both cell types support the islet by providing (1) a conduit for delivery and exchange of nutrients and hormones; (2) paracri…
View article: Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice
Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice Open
View article: 9: Pancreatic and islet vasculature are significantly diminished in CF donors – a potential contributor to insulin deficiency in CF
9: Pancreatic and islet vasculature are significantly diminished in CF donors – a potential contributor to insulin deficiency in CF Open
View article: SGLT2-i improves markers of islet endothelial cell function in db/db diabetic mice
SGLT2-i improves markers of islet endothelial cell function in db/db diabetic mice Open
Islet endothelial cells produce paracrine factors important for islet beta-cell function and survival. Under conditions of type 2 diabetes, islet endothelial cells exhibit a dysfunctional phenotype including increased expression of genes i…
View article: Consensus guidelines for the use and interpretation of angiogenesis assays
Consensus guidelines for the use and interpretation of angiogenesis assays Open
View article: Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury
Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury Open