Alfred Ian Lee
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View article: Molecular clues to venous thromboembolism recurrence
Molecular clues to venous thromboembolism recurrence Open
View article: A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry
A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry Open
Introduction Antiphospholipid syndrome (APS) is an autoimmune disease with thromboembolic and obstetric morbidity arising via a model of immunothrombosis. Individuals with APS may present with thrombotic (TAPS), obstetric (OAPS), or microv…
View article: Initial management of patients with acquired aplastic anemia in the United States: results from a large national claims database
Initial management of patients with acquired aplastic anemia in the United States: results from a large national claims database Open
Acquired aplastic anemia (AA) is an immune-mediated disorder leading to bone marrow failure characterized by pancytopenia, with infectious and bleeding complications. The disease course may be complicated by paroxysmal nocturnal hemoglobin…
View article: Intercontinental variations in the presentation and management of venous thromboembolism
Intercontinental variations in the presentation and management of venous thromboembolism Open
Objective: Venous thromboembolism (VTE) is a global disease with significant morbidity and mortality. However, variations in presentation and management of VTE between different continents have not been studied. This retrospective analysis…
View article: In-human clinical experience with direct stick embolization of low-flow vascular malformations using a mammalian target of rapamycin inhibitor
In-human clinical experience with direct stick embolization of low-flow vascular malformations using a mammalian target of rapamycin inhibitor Open
View article: American Society of Hematology living guidelines on use of anticoagulation for thromboprophylaxis for patients with COVID-19: executive summary
American Society of Hematology living guidelines on use of anticoagulation for thromboprophylaxis for patients with COVID-19: executive summary Open
Background COVID-19–related critical and acute illness is associated with an increased risk of venous thromboembolism (VTE). These evidence-based recommendations of the American Society of Hematology (ASH) are intended to support patients,…
View article: Cost-effectiveness of iptacopan for paroxysmal nocturnal hemoglobinuria
Cost-effectiveness of iptacopan for paroxysmal nocturnal hemoglobinuria Open
Iptacopan, a novel oral factor B inhibitor, recently obtained US Food and Drug Administration approval for treating paroxysmal nocturnal hemoglobinuria, a rare blood disorder characterized by persistent complement-mediated hemolytic anemia…
View article: Evaluating the impact of a year-long external mentorship pilot program in classical hematology
Evaluating the impact of a year-long external mentorship pilot program in classical hematology Open
Effective mentorship is a pivotal factor in shaping the career trajectory of trainees interested in classical hematology (CH), which is of critical importance due to the anticipated decline in the CH workforce. However, there is a lack of …
View article: Trainees’ perspectives on sickle cell education: a qualitative needs assessment
Trainees’ perspectives on sickle cell education: a qualitative needs assessment Open
Background Sickle cell disease (SCD) exemplifies many of the social, racial, and healthcare equity issues in the United States. Despite its high morbidity, mortality, and cost of care, SCD has not been prioritized in research and clinical …
View article: Cost‐effectiveness of sutimlimab in cold agglutinin disease
Cost‐effectiveness of sutimlimab in cold agglutinin disease Open
Primary cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia caused by cold‐reactive antibodies that bind to red blood cells and lead to complement‐mediated hemolysis. Patients with primary CAD experience the burden of incre…
View article: Providing 0.1 Full-Time Equivalent (FTE) Support to Fellowship Core Faculty Improves Faculty Involvement in Fellowship Education and Recruitment
Providing 0.1 Full-Time Equivalent (FTE) Support to Fellowship Core Faculty Improves Faculty Involvement in Fellowship Education and Recruitment Open
View article: Evaluating the clinical validity of genes related to hemostasis and thrombosis using the Clinical Genome Resource gene curation framework
Evaluating the clinical validity of genes related to hemostasis and thrombosis using the Clinical Genome Resource gene curation framework Open
View article: The 2023 <scp>ACR</scp>/<scp>EULAR</scp> Antiphospholipid Syndrome Classification Criteria
The 2023 <span>ACR</span>/<span>EULAR</span> Antiphospholipid Syndrome Classification Criteria Open
Objective To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) and EULAR. Methods This int…
View article: 2023 ACR/EULAR antiphospholipid syndrome classification criteria
2023 ACR/EULAR antiphospholipid syndrome classification criteria Open
View article: Association of renalase with clinical outcomes in hospitalized patients with COVID-19
Association of renalase with clinical outcomes in hospitalized patients with COVID-19 Open
Renalase is a secreted flavoprotein with anti-inflammatory and pro-cell survival properties. COVID-19 is associated with disordered inflammation and apoptosis. We hypothesized that blood renalase levels would correspond to severe COVID-19 …
View article: Consensus recommendations on peripheral blood smear review: defining curricular standards and fellow competency
Consensus recommendations on peripheral blood smear review: defining curricular standards and fellow competency Open
Graduate medical education training in hematology in North America is accredited by the Accreditation Council for Graduate Medical Education (ACGME). Trainees routinely review peripheral blood smears (PBS) in providing clinical care. Compe…
View article: Summiting thrombotic hazards in glioma
Summiting thrombotic hazards in glioma Open
View article: Case 8-2023: A 71-Year-Old Woman with Refractory Hemolytic Anemia
Case 8-2023: A 71-Year-Old Woman with Refractory Hemolytic Anemia Open
A 71-year-old woman with breast cancer and systemic sclerosis was admitted because of refractory hemolytic anemia. A diagnostic test was performed.
View article: Please Do Call Us Classical Hematologists
Please Do Call Us Classical Hematologists Open
View article: Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome
Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome Open
Patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) often receive antibacterial prophylaxis. Antibacterial agents can cause elevations in the prothrombin time and international normalized ratio (INR). The impact o…
View article: Thrombosis questions from the inpatient wards
Thrombosis questions from the inpatient wards Open
The multifaceted pathophysiologic processes that comprise thrombosis and thromboembolic diseases take on a particular urgency in the hospitalized setting. In this review, we explore 3 cases of thrombosis from the inpatient wards: purpura f…
View article: COVID-19 and antiphospholipid antibodies
COVID-19 and antiphospholipid antibodies Open
View article: American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis for patients with COVID-19: March 2022 update on the use of anticoagulation in critically ill patients
American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis for patients with COVID-19: March 2022 update on the use of anticoagulation in critically ill patients Open
Background: COVID-19–related critical illness is associated with an increased risk of venous thromboembolism (VTE). Objective: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, cl…
View article: American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: January 2022 update on the use of therapeutic-intensity anticoagulation in acutely ill patients
American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: January 2022 update on the use of therapeutic-intensity anticoagulation in acutely ill patients Open
Background: COVID-19–related acute illness is associated with an increased risk of venous thromboembolism (VTE). Objective: These evidence-based guidelines from the American Society of Hematology (ASH) are intended to support patients, cli…
View article: Burnout in US hematologists and oncologists: impact of compensation models and advanced practice provider support
Burnout in US hematologists and oncologists: impact of compensation models and advanced practice provider support Open
Burnout is prevalent throughout medicine. Few large-scale studies have examined the impact of physician compensation or clinical support staff on burnout among hematologists and oncologists. In 2019, the American Society of Hematology cond…
View article: Association of renalase with clinical outcomes in hospitalized patients with COVID-19
Association of renalase with clinical outcomes in hospitalized patients with COVID-19 Open
Renalase is a secreted flavoprotein with anti-inflammatory and pro-cell survival properties. COVID-19 is associated with disordered inflammation and apoptosis. We hypothesized that blood renalase levels would correspond to severe COVID-19 …
View article: A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences
A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences Open
View article: Cost‐effectiveness of second‐line therapies in adults with chronic immune thrombocytopenia
Cost‐effectiveness of second‐line therapies in adults with chronic immune thrombocytopenia Open
Major options for second‐line therapy in adults with chronic immune thrombocytopenia (ITP) include splenectomy, rituximab, and thrombopoietin receptor agonists (TRAs). The American Society of Hematology guidelines recommend rituximab over …
View article: Clinical characteristics, time course, and outcomes of major bleeding according to bleeding site in patients with venous thromboembolism
Clinical characteristics, time course, and outcomes of major bleeding according to bleeding site in patients with venous thromboembolism Open
View article: Impact of COVID-19 on Hematology-Oncology Fellowship Programs: A Quantitative and Qualitative Survey Assessment of Fellowship Program Directors
Impact of COVID-19 on Hematology-Oncology Fellowship Programs: A Quantitative and Qualitative Survey Assessment of Fellowship Program Directors Open
PURPOSE: The COVID-19 pandemic led to unprecedented challenges in medical training, and we sought to assess the specific impact of COVID-19 on hematology-oncology (HO) fellowship programs. METHODS: We conducted a cross-sectional anonymous …