Alfred Ross
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View article: A high-resolution data set of fatty acid-binding protein structures. I. Dynamics of FABP4 and ligand binding
A high-resolution data set of fatty acid-binding protein structures. I. Dynamics of FABP4 and ligand binding Open
Fatty acid-binding proteins (FABPs) are involved in the uptake and intracellular trafficking of fatty acids for metabolic and gene-regulatory purposes. FABPs are known to associate with membranes and also enter the nucleus. Using NMR and a…
View article: Liquid crystal phase formation and non-Newtonian behavior of oligonucleotide formulations
Liquid crystal phase formation and non-Newtonian behavior of oligonucleotide formulations Open
Viscosity behavior of liquid oligonucleotide therapeutics and its dependence on formulation properties has been poorly studied to date. We observed a high increase in viscosity and solidification of therapeutic oligonucleotide formulations…
View article: Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics
Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics Open
The increased interest in using monoclonal antibodies (mAbs) as a platform for biopharmaceuticals has led to the need for new analytical techniques that can precisely assess physicochemical properties of these large and very complex drugs …
View article: Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies
Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies Open
Doublecortin is a microtubule-associated protein produced during neurogenesis. The protein stabilizes microtubules and stimulates their polymerization, which allows migration of immature neurons to their designated location in the brain. M…