Alfred W. Bronkhorst
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View article: Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining
Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining Open
Identification of novel drug targets is a key component of modern drug discovery. While antimalarial targets are often identified through the mechanism of action studies on phenotypically derived inhibitors, this method tends to be time- a…
View article: Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining
Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining Open
The identification of novel drug targets for the purpose of designing small molecule inhibitors is key component to modern drug discovery. In malaria parasites, discoveries of antimalarial targets have primarily occurred retroactively by i…
View article: Author Correction: piRNA processing by a trimeric Schlafen-domain nuclease
Author Correction: piRNA processing by a trimeric Schlafen-domain nuclease Open
View article: An extended Tudor domain within Vreteno interconnects <scp>Gtsf1L</scp> and Ago3 for <scp>piRNA</scp> biogenesis in <i>Bombyx mori</i>
An extended Tudor domain within Vreteno interconnects <span>Gtsf1L</span> and Ago3 for <span>piRNA</span> biogenesis in <i>Bombyx mori</i> Open
Piwi‐interacting RNAs (piRNAs) direct PIWI proteins to transposons to silence them, thereby preserving genome integrity and fertility. The piRNA population can be expanded in the ping‐pong amplification loop. Within this process, piRNA‐ass…
View article: piRNA processing by a trimeric Schlafen-domain nuclease
piRNA processing by a trimeric Schlafen-domain nuclease Open
Transposable elements are genomic parasites that expand within and spread between genomes 1 . PIWI proteins control transposon activity, notably in the germline 2,3 . These proteins recognize their targets through small RNA co-factors name…
View article: An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in<i>Bombyx mori</i>
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in<i>Bombyx mori</i> Open
Piwi-interacting RNAs (piRNAs) direct PIWI proteins to transposons to silence them, thereby preserving genome integrity and fertility. The piRNA population can be expanded in the ping-pong amplification loop. Within this process, piRNA-ass…
View article: piRNA processing by a trimeric Schlafen-domain nuclease
piRNA processing by a trimeric Schlafen-domain nuclease Open
Transposable elements are genomic parasites that expand within and spread between genomes 1 . Piwi proteins control transposon activity, notably in the germline 2,3 . These proteins recognize their targets through small RNA co-factors name…
View article: Membrane-associated cytoplasmic granules carrying the Argonaute protein WAGO-3 enable paternal epigenetic inheritance in Caenorhabditis elegans
Membrane-associated cytoplasmic granules carrying the Argonaute protein WAGO-3 enable paternal epigenetic inheritance in Caenorhabditis elegans Open
View article: A DNA virus-encoded immune antagonist fully masks the potent antiviral activity of RNAi in <i>Drosophila</i>
A DNA virus-encoded immune antagonist fully masks the potent antiviral activity of RNAi in <i>Drosophila</i> Open
Coevolution of viruses and their hosts may lead to viral strategies to avoid, evade, or suppress antiviral immunity. An example is antiviral RNA interference (RNAi) in insects: the host RNAi machinery processes viral double-stranded RNA in…
View article: Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification
Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification Open
View article: Trimming it short: PNLDC1 is required for piRNA maturation during mouse spermatogenesis
Trimming it short: PNLDC1 is required for piRNA maturation during mouse spermatogenesis Open
View article: Tdrd6a regulates the aggregation of Buc into functional subcellular compartments that drive germ cell specification
Tdrd6a regulates the aggregation of Buc into functional subcellular compartments that drive germ cell specification Open
Summary In recent years, it has become clear that phase separation represents an important class of subcellular compartmentalization. However, relatively little is known about how the formation or disassembly of such compartments is regula…
View article: Viral suppressors of RNAi employ a rapid screening mode to discriminate viral RNA from cellular small RNA
Viral suppressors of RNAi employ a rapid screening mode to discriminate viral RNA from cellular small RNA Open
View article: Viral suppressors of RNAi employ a rapid screening mode to discriminate viral RNA from cellular small RNA
Viral suppressors of RNAi employ a rapid screening mode to discriminate viral RNA from cellular small RNA Open
RNA interference (RNAi) is an indispensable mechanism for antiviral defense in insects, including mosquitoes that transmit human diseases. To escape this antiviral defense system, viruses encode suppressors of RNAi that prevent elimination…
View article: The Epigenetic Regulator G9a Mediates Tolerance to RNA Virus Infection in Drosophila
The Epigenetic Regulator G9a Mediates Tolerance to RNA Virus Infection in Drosophila Open
Little is known about the tolerance mechanisms that reduce the negative effects of microbial infection on host fitness. Here, we demonstrate that the histone H3 lysine 9 methyltransferase G9a regulates tolerance to virus infection by shapi…