Ali Al‐Hashimi
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View article: Correction: Autoantibodies against the cell surface–associated chaperone GRP78 stimulate tumor growth via tissue factor
Correction: Autoantibodies against the cell surface–associated chaperone GRP78 stimulate tumor growth via tissue factor Open
View article: Survey and Identification of Fusarium Head Blight Pathogens of Wheat in the Western Cape Region of South Africa
Survey and Identification of Fusarium Head Blight Pathogens of Wheat in the Western Cape Region of South Africa Open
Fusarium head blight (FHB) is a major disease affecting wheat production worldwide, caused by multiple Fusarium species. In this study, seven Fusarium strains were isolated from wheat fields across the Western Cape region of South Africa a…
View article: Mechanistic insight into the anti-alternaria activity of bimetallic zinc oxide and silver/zinc oxide nanoparticles
Mechanistic insight into the anti-alternaria activity of bimetallic zinc oxide and silver/zinc oxide nanoparticles Open
View article: Phyto-Synthesis and Characterization of Silver Nanoparticles Using Box-Behnken Design and Its Anti-Alternaria Activity
Phyto-Synthesis and Characterization of Silver Nanoparticles Using Box-Behnken Design and Its Anti-Alternaria Activity Open
Alternaria alternata is a global fungal pathogen that causes symptoms such as leaf blight and seed rot resulting in economically significant yield losses in different varieties of crops. Green synthesis of nanoparticles is preferred over o…
View article: Draft Whole-Genome Sequence of <i>Penicillium simplicissimum</i> A4, a Putative Endophyte from <i>Echium plantagineum</i>
Draft Whole-Genome Sequence of <i>Penicillium simplicissimum</i> A4, a Putative Endophyte from <i>Echium plantagineum</i> Open
We report the draft whole-genome sequence of the putative endophytic fungus Penicillium simplicissimum A4, isolated from the roots of Echium plantagineum plants. The genome was sequenced using PacBio technology with an estimated genome siz…
View article: Clinical Interaction Effect of Azithromycin and Citalopram in New 2-[2- - (4,5-Di Methoxy Carboxy Phenyl) Azo]-Imidazole (DMCPAI) - Metal Complexes Against Nikethamide Induce Lethal Convulsion
Clinical Interaction Effect of Azithromycin and Citalopram in New 2-[2- - (4,5-Di Methoxy Carboxy Phenyl) Azo]-Imidazole (DMCPAI) - Metal Complexes Against Nikethamide Induce Lethal Convulsion Open
Objectives:The ligand of heterocyclic azo dye 2-[2--(4,5-dimethoxy carboxy phenyl) azo]-Imidazole, (DMCPAI) was achieve by coupling between a diazonium chloride solution of 2-amino -4,5-dimethoxy benzoic acid with imidazole in alkaline eth…
View article: The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury
The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury Open
Individuals harboring the loss-of-function (LOF) proprotein convertase subtilisin/kexin type 9 Gln152His variation (PCSK9Q152H) have low circulating low-density lipoprotein cholesterol levels and are therefore protected against cardiovascu…
View article: Acknowledgments
Acknowledgments Open
View article: Pcsk9 knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice
Pcsk9 knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice Open
View article: The Effect of ᵞ -ray doses on Phagocyte Functional activity of Granulocytes by mean of Chemiluminescence
The Effect of ᵞ -ray doses on Phagocyte Functional activity of Granulocytes by mean of Chemiluminescence Open
White blood cells are the fundamental viable defense barrier in the body immune system against foreign bodies such as bacteria parasites viruses.All types of leukocytes have the ability to produce reactive oxygen species such as singlet ox…
View article: MP81-18 INVESTIGATING A NOVEL RECOMBINANT ANTIBODY TO ATTENUATE PROSTATE CANCER PROGRESSION BY TARGETING CELL SURFACE GRP78
MP81-18 INVESTIGATING A NOVEL RECOMBINANT ANTIBODY TO ATTENUATE PROSTATE CANCER PROGRESSION BY TARGETING CELL SURFACE GRP78 Open
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology III (MP81)1 Apr 2019MP81-18 INVESTIGATING A NOVEL RECOMBINANT ANTIBODY TO ATTENUATE PROSTATE CANCER PROGRESSION BY TARGETING CELL SURFACE GRP78 Ali Al-Hashi…
View article: GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4)
GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4) Open
The heart manifests hypertrophic growth in response to elevation of afterload pressure. Cardiac myocyte growth involves new protein synthesis and membrane expansion, of which a number of cellular quality control machineries are stimulated …
View article: Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions
Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions Open
The 78-kDa glucose-regulated protein (GRP78) is an ER molecular chaperone that aids in protein folding and secretion. However, pathological conditions that cause ER stress can promote the relocalization of GRP78 to the cell surface (csGRP7…
View article: Issue Information ‐ Editorial Board
Issue Information ‐ Editorial Board Open
Rest of World), €6139 (Europe), £4854 (UK).Prices are exclusive of tax.Asia-Pacifi c GST, Canadian GST/HST and European VAT will be applied at the appropriate rates.For more information on current tax rates, please go to www.wileyonlinelib…
View article: Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation
Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation Open
Rationale: Restoration of coronary artery blood flow is the most effective means of ameliorating myocardial damage triggered by ischemic heart disease. However, coronary reperfusion elicits an increment of additional injury to the myocardi…
View article: Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained
Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained Open
The proprotein convertase subtilisin/kexin type-9 (PCSK9) plays a central role in cardiovascular disease (CVD) by degrading hepatic low-density lipoprotein receptor (LDLR). As such, loss-of-function (LOF) PCSK9 variants that fail to exit t…
View article: Autoantibodies against the cell surface–associated chaperone GRP78 stimulate tumor growth via tissue factor
Autoantibodies against the cell surface–associated chaperone GRP78 stimulate tumor growth via tissue factor Open
View article: Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism
Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism Open
Accumulating evidence implicates endoplasmic reticulum (ER) stress as a mediator of impaired lipid metabolism, thereby contributing to fatty liver disease and atherosclerosis. Previous studies demonstrated that ER stress can activate the s…
View article: Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth
Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth Open
Background Monocyte recruitment leads to accumulation of macrophage foam cells and contributes to atherosclerotic lesion growth. Recent studies have reported that lesion‐resident macrophages can proliferate and represent a major cellular c…
View article: PATHOGENESIS OF ANTI-GRP78 AUTOANTIBODIES IN PROSTATE CANCER
PATHOGENESIS OF ANTI-GRP78 AUTOANTIBODIES IN PROSTATE CANCER Open
Prostate Cancer Canada estimates that sixty-five Canadian men will be diagnosed with prostate cancer (PC) daily, thus, PCa is the most frequently diagnosed cancer and the second leading cause of caner-related deaths in men. Currently, the …
View article: Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.
Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores. Open
The phospho-eIF2␣ immunoblots for tunicamycin and thapsigargin treatment in Fig. 3A were inadvertently switched.The corrected figure is shown below.This correction does not affect the interpretation of the results or the conclusions of thi…