Ali Azghani
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View article: Sentinel Surveillance: Hepatitis E and the Case for Domestic Animal Surveillance
Sentinel Surveillance: Hepatitis E and the Case for Domestic Animal Surveillance Open
Globalization and geoclimatic changes are driving the emergence and spread of infectious diseases. Today, nearly two thirds of emerging Infectious diseases are zoonotic in nature (75% originating in wildlife). Despite individuals generally…
View article: Intrapleural Fibrinolytic Interventions for Retained Hemothoraces in Rabbits
Intrapleural Fibrinolytic Interventions for Retained Hemothoraces in Rabbits Open
Bleeding within the pleural space may result in persistent clot formation called retained hemothorax (RH). RH is prone to organization, which compromises effective drainage, leading to lung restriction and dyspnea. Intrapleural fibrinolyti…
View article: A Novel Rabbit Model of Retained Hemothorax with Pleural Organization
A Novel Rabbit Model of Retained Hemothorax with Pleural Organization Open
Retained hemothorax (RH) is a commonly encountered and potentially severe complication of intrapleural bleeding that can organize with lung restriction. Early surgical intervention and intrapleural fibrinolytic therapy have been advocated.…
View article: Targeting the PAI-1 Mechanism with a Small Peptide Increases the Efficacy of Alteplase in a Rabbit Model of Chronic Empyema
Targeting the PAI-1 Mechanism with a Small Peptide Increases the Efficacy of Alteplase in a Rabbit Model of Chronic Empyema Open
The incidence of empyema is increasing and associated with a mortality rate of 20% in patients older than 65 years. Since 30% of patients with advanced empyema have contraindications to surgical treatment, novel, low-dose, pharmacological …
View article: Precision targeting of the plasminogen activator inhibitor‐1 mechanism increases efficacy of fibrinolytic therapy in empyema
Precision targeting of the plasminogen activator inhibitor‐1 mechanism increases efficacy of fibrinolytic therapy in empyema Open
Plasminogen activator inhibitor-1 (PAI-1) is an endogenous irreversible inhibitor of tissue-type (tPA) and urokinase (uPA) plasminogen activators. PAI-1-targeted fibrinolytic therapy (PAI-1-TFT) is designed to decrease the therapeutic dose…
View article: Inhibition of Platelet Adhesion from Surface Modified Polyurethane Membranes
Inhibition of Platelet Adhesion from Surface Modified Polyurethane Membranes Open
Coronary thrombosis is one of the leading causes of mortality and morbidity in cardiovascular diseases, and patients who received vascular stent treatments are likely to suffer from restenosis due to tissue damage from stenting procedures …
View article: Precision Targeting of the Plasminogen Activator Inhibitor-1 Mechanism Increases Efficacy of Fibrinolytic Therapy in Empyema
Precision Targeting of the Plasminogen Activator Inhibitor-1 Mechanism Increases Efficacy of Fibrinolytic Therapy in Empyema Open
Plasminogen activator inhibitor-1 (PAI-1) is an endogenous irreversible inhibitor of tissue-type (tPA) and urokinase (uPA) plasminogen activators. PAI-1-targeted fibrinolytic therapy (PAI-1-TFT) is designed to decrease the therapeutic dose…
View article: Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits
Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits Open
Elevated active plasminogen activator inhibitor-1 (PAI-1) has an adverse effect on the outcomes of intrapleural fibrinolytic therapy (IPFT) in tetracycline-induced pleural injury in rabbits. To enhance IPFT with prourokinase (scuPA), two m…
View article: Efficacy of neutral and negatively charged liposome-loaded gentamicin on planktonic bacteria and biofilm communities
Efficacy of neutral and negatively charged liposome-loaded gentamicin on planktonic bacteria and biofilm communities Open
We investigated the efficacy of liposomal gentamicin formulations of different surface charges against Pseudomonas aeruginosa and Klebsiella oxytoca. The liposomal gentamicin formulations were prepared by the dehydration-rehydration method…
View article: Precision-guided, Personalized Intrapleural Fibrinolytic Therapy for Empyema and Complicated Parapneumonic Pleural Effusions: The Case for The Fibrinolytic Potential
Precision-guided, Personalized Intrapleural Fibrinolytic Therapy for Empyema and Complicated Parapneumonic Pleural Effusions: The Case for The Fibrinolytic Potential Open
Complicated pleural effusions and empyema with loculation and failed drainage are common clinical problems. In adults, intrapleural fibrinolytic therapy is commonly used with variable results and therapy remains empiric. Despite the intrap…
View article: Dose dependency of outcomes of intrapleural fibrinolytic therapy in new rabbit empyema models
Dose dependency of outcomes of intrapleural fibrinolytic therapy in new rabbit empyema models Open
The incidence of empyema (EMP) is increasing worldwide; EMP generally occurs with pleural loculation and impaired drainage is often treated with intrapleural fibrinolytic therapy (IPFT) or surgery. A number of IPFT options are used clinica…
View article: The time course of resolution of adhesions during fibrinolytic therapy in tetracycline-induced pleural injury in rabbits
The time course of resolution of adhesions during fibrinolytic therapy in tetracycline-induced pleural injury in rabbits Open
The time required for the effective clearance of pleural adhesions/organization after intrapleural fibrinolytic therapy (IPFT) is unknown. Chest ultrasonography and computed tomography (CT) were used to assess the efficacy of IPFT in a rab…