Ali Chen
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View article: Desulfovibrio vulgaris exacerbates sepsis by inducing inflammation and oxidative stress in multiple organs
Desulfovibrio vulgaris exacerbates sepsis by inducing inflammation and oxidative stress in multiple organs Open
Introduction Sepsis is a life-threatening condition that often leads to organ dysfunction and systemic inflammation, with gut microbiota dysbiosis playing a crucial role in its pathogenesis. The role of Desulfovibrio vulgaris ( D. vulgaris…
View article: [Retracted] Sinomenine hydrochloride inhibits cell survival in human hepatoma Huh7 cells
[Retracted] Sinomenine hydrochloride inhibits cell survival in human hepatoma Huh7 cells Open
[This retracts the article DOI: 10.3892/br.2018.1084.].
View article: Impulse oscillometry in assessing small airway function in asthma
Impulse oscillometry in assessing small airway function in asthma Open
Background Small airway dysfunction (SAD) can occur in asthma patients with normal spirometry, impacting symptoms and disease control. Small airway dysfunction is linked to more severe symptoms and worse spirometry, poor asthma control, no…
View article: Natural Polyphenol-Mediated Inhibition of Ferroptosis Alleviates Oxidative Damage and Inflammation in Acute Liver Injury
Natural Polyphenol-Mediated Inhibition of Ferroptosis Alleviates Oxidative Damage and Inflammation in Acute Liver Injury Open
Acetaminophen (APAP) overdose has long been recognized as the main cause of drug-induced liver injury (DILI), characterized by glutathione (GSH) depletion and reactive oxygen species (ROS) accumulation, leading to ferroptosis and inflammat…
View article: Investigating the Mechanism of Qifenggubiao Granules in COPD Treatment: An Integrated Exploration of Ferroptosis and the Gut–Lung Axis
Investigating the Mechanism of Qifenggubiao Granules in COPD Treatment: An Integrated Exploration of Ferroptosis and the Gut–Lung Axis Open
Although an increasing number of studies focus on treating chronic obstructive pulmonary disease (COPD) through the gut–lung axis and immunomodulation, its underlying mechanisms remain poorly understood. Previous research has shown that Qi…
View article: Comparison between community-acquired pneumonia and post-obstructive pneumonia associated with endobronchial tumors
Comparison between community-acquired pneumonia and post-obstructive pneumonia associated with endobronchial tumors Open
Background Endobronchial tumors can infiltrate the bronchial wall or protrude into the bronchial lumen, causing post-obstructive pneumonia (POP). Differentiating between POP and community-acquired pneumonia (CAP) is challenging due to simi…
View article: Comparison between Community-Acquired Pneumonia and Post-Obstructive Pneumonia Associated with Endobronchial Tumors
Comparison between Community-Acquired Pneumonia and Post-Obstructive Pneumonia Associated with Endobronchial Tumors Open
Background Endobronchial tumors can infiltrate the bronchial wall or protrude into the bronchial lumen, causing post-obstructive pneumonia (POP). Differentiating between POP and community-acquired pneumonia (CAP) is challenging due to simi…
View article: Investigating the mechanism of cornel iridoid glycosides on type 2 diabetes mellitus using serum and urine metabolites in rats
Investigating the mechanism of cornel iridoid glycosides on type 2 diabetes mellitus using serum and urine metabolites in rats Open
This study confirmed the antidiabetic effects of CIG and revealed that CIG effectively controlled metabolic disorders in T2DM rats. This seems to be meaningful for the clinical application of CIG, and can benefit further studies on CIG mec…
View article: Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment
Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment Open
Apatinib plus chemotherapy demonstrates good efficacy in multiple advanced carcinomas; however, its use in patients with advanced lung adenocarcinoma (LUAD) has not yet been assessed. The present study evaluated the potential benefits of a…
View article: SKP alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1α/HO-1 pathway based on network pharmacology analysis and experimental validation.
SKP alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1α/HO-1 pathway based on network pharmacology analysis and experimental validation. Open
Backgroud Diabetic kidney disease (DKD) represents a microvascular complication of diabetes mellitus. Shenkang Pills (SKP), a traditional Chinese medicine formula, has been widely used in the treatment of DKD and has obvious antioxidant ef…
View article: AIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3
AIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3 Open
This work was devised to discuss the effect of AIM2 on the immunosuppression of LUAD tumors, as well as its molecular mechanism. An allograft mouse model was built. Mouse macrophages were isolated and collected. The infiltration level of M…
View article: Self-delivery immunological adenosine effector for photodynamic activated immunotherapy against metastatic tumors
Self-delivery immunological adenosine effector for photodynamic activated immunotherapy against metastatic tumors Open
Therapy-induced immunogenic cell death (ICD) can trigger a burst release of immunostimulatory signals, but some of them can be converted into immunosuppressive factors to extensively restrict systemic anti-tumor immunity. In this work, a s…
View article: Chimeric Peptide Engineered Nanomedicine for Synergistic Suppression of Tumor Growth and Therapy-Induced Hyperlipidemia by mTOR and PCSK9 Inhibition
Chimeric Peptide Engineered Nanomedicine for Synergistic Suppression of Tumor Growth and Therapy-Induced Hyperlipidemia by mTOR and PCSK9 Inhibition Open
Chemotherapy-induced side effects restrain anti-tumor efficiency, with hyperlipidemia being the most common accompanying disease to cause treatment failure. In this work, a chimeric peptide-engineered nanomedicine (designated as PRS) was f…
View article: Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice
Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice Open
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI). The impact of the gut microbiota and associated metabolites on APAP and liver function remains unclear. We show that APAP disturbance is associated with …
View article: Development of a Reliable ic-ELISA with a Robust Antimatrix Interference Capability Based on QuEChERS Technology for the Rapid Detection of Zearalenone in Edible and Medical Coix Seeds and Subsequent Risk Assessments
Development of a Reliable ic-ELISA with a Robust Antimatrix Interference Capability Based on QuEChERS Technology for the Rapid Detection of Zearalenone in Edible and Medical Coix Seeds and Subsequent Risk Assessments Open
Indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) is an ideal immunoassay method for large-scale screenings to detect mycotoxin contaminants. However, the matrix effect of complicated samples has always been challenging whe…
View article: Gut Commensal Fungi Protect Against Acetaminophen-Induced Hepatotoxicity by Reducing Cyp2a5 Expression in Mice
Gut Commensal Fungi Protect Against Acetaminophen-Induced Hepatotoxicity by Reducing Cyp2a5 Expression in Mice Open
Background and Aims Drug-induced liver injury (DILI) is a common cause of acute liver failure and represents a significant global public health problem. When discussing the gut-liver axis, although a great deal of research has focused on t…
View article: Self-remedied Nanomedicine for Surmounting the Achilles's Heel of Photodynamic Tumor Therapy
Self-remedied Nanomedicine for Surmounting the Achilles's Heel of Photodynamic Tumor Therapy Open
Background: Photodynamic therapy (PDT) has been recognized as a promising tumor treatment for its minimal invasiveness, low side effects and on-demand light controllability. However, the oxygen-dependent PDT could exacerbate tumor hypoxia …
View article: Guided Lamb waves in reconfigurable phononic crystal waveguides
Guided Lamb waves in reconfigurable phononic crystal waveguides Open
International audience
View article: Diagnosing Coronavirus Disease 2019 (COVID-19): Efficient Harris Hawks-Inspired Fuzzy K-Nearest Neighbor Prediction Methods
Diagnosing Coronavirus Disease 2019 (COVID-19): Efficient Harris Hawks-Inspired Fuzzy K-Nearest Neighbor Prediction Methods Open
This study is devoted to proposing a useful intelligent prediction model to distinguish the severity of COVID-19, to provide a more fair and reasonable reference for assisting clinical diagnostic decision-making. Based on patients' necessa…
View article: Tunable multifunctional fish-bone elastic metasurface for the wavefront manipulation of the transmitted in-plane waves
Tunable multifunctional fish-bone elastic metasurface for the wavefront manipulation of the transmitted in-plane waves Open
In this work, a tunable fish-bone elastic metasurface is used to manipulate in-plane waves, which are more complex than flexural or out-of-plane waves because of the coupling of P- and SV-waves. First, refracted generalized Snell's law (GS…
View article: Cu-catalyzed cross-coupling of methyl ketones and pyridin-2-amines for the synthesis of N-(2-pyridyl)-α-ketoamides
Cu-catalyzed cross-coupling of methyl ketones and pyridin-2-amines for the synthesis of N-(2-pyridyl)-α-ketoamides Open
An efficient copper-catalyzed strategy for the synthesis of α-ketoamides via cross-coupling of methyl ketones and pyridin-2-amines is described. This transformation has provided a simple process for the formation of C−N and C=O bonds to pr…
View article: Facile Synthesis of Solvent Sensitive Fluorinated Graphene Nanoscrolls and Application as a Cathode Material for Lithium Ion Batteries
Facile Synthesis of Solvent Sensitive Fluorinated Graphene Nanoscrolls and Application as a Cathode Material for Lithium Ion Batteries Open
In this work, fluorinated graphene nanoscrolls (FGN) were synthesized via facile chemical methods under simple and mild conditions. Interestingly, the formation of the featured FGN was significantly solvent sensitive. Experimental results …
View article: Thermal wave crystals based on the dual-phase-lag model
Thermal wave crystals based on the dual-phase-lag model Open
Thermal wave crystals based on the dual-phase-lag model are investigated in this paper by both theoretical analysis and numerical simulation to control the non-Fourier heat conduction process. The transfer matrix method is used to calculat…
View article: Novel Graphene/In2O3 Nanocubes Preparation and Selective Electrochemical Detection for L-Lysine of Camellia nitidissima Chi
Novel Graphene/In2O3 Nanocubes Preparation and Selective Electrochemical Detection for L-Lysine of Camellia nitidissima Chi Open
In this work, novel graphene/In2O3 (GR/In2O3) nanocubes were prepared via one-pot solvothermal treatment, reduction reaction, and successive annealing technology at 600 °C step by step. Interestingly, In2O3 with featured cubic morphology w…