Abdelgawad A. Fahmi
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View article: Synthesis, characterization, and cytotoxicity of doxorubicin-loaded polycaprolactone nanocapsules as controlled anti-hepatocellular carcinoma drug release system
Synthesis, characterization, and cytotoxicity of doxorubicin-loaded polycaprolactone nanocapsules as controlled anti-hepatocellular carcinoma drug release system Open
View article: The use of ultrasound (UAE) and microwaves (MAE) to improve the extraction of pharmaceutically active materials from the fruit of the prickly pear (Opuntia ficus-indica)
The use of ultrasound (UAE) and microwaves (MAE) to improve the extraction of pharmaceutically active materials from the fruit of the prickly pear (Opuntia ficus-indica) Open
Background Conventional extraction methods have many limitations and drawbacks, including, prolonged extraction time, present safety concern and environmental risks, with low quality extracts. We report the use of ultrasonic (UAE) and micr…
View article: Facile Synthesis, Biological Evaluation, DFT Studies and <i>in Silico</i> Prediction ADME/Pharmacokinetics Properties of <i>N</i>-(1-(2-Chlorobenzo[h]Quinolin-3-yl)-1-Substituted-vin-2-yl)Benzamide Derivatives
Facile Synthesis, Biological Evaluation, DFT Studies and <i>in Silico</i> Prediction ADME/Pharmacokinetics Properties of <i>N</i>-(1-(2-Chlorobenzo[h]Quinolin-3-yl)-1-Substituted-vin-2-yl)Benzamide Derivatives Open
A new series of various N-(1-(2-chlorobenzo[h]quinolin-3-yl)-1-substituted-vin-2-yl)benzamide derivatives was designed and synthesized based on the 2-chlorobenzo[h]quinoline core as potential antioxidant and insecticid…
View article: Diagnostic sensitivity of arginase, alpha-1 antitrypsin and alpha-fetoprotein in hepatitis patients
Diagnostic sensitivity of arginase, alpha-1 antitrypsin and alpha-fetoprotein in hepatitis patients Open
Chronic hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) are common liver diseases that lead to death in Egypt, especially in men. The current study aimed to evaluate the diagnostic sensitivity of arginase (ARG) activity, alpha-1…
View article: Effect of Cell Phone-Emitted Electromagnetic Waves on Levels of Male Sex Hormones and Oxidative Stress Biomarkers in Humans
Effect of Cell Phone-Emitted Electromagnetic Waves on Levels of Male Sex Hormones and Oxidative Stress Biomarkers in Humans Open
Cell phones emit Electromagnetic Waves (EMWs) that may have adverse effects on human health. The study aimed to investigate some possible health impacts associated with cell phone-derived EMWs on male sex hormones and oxidative stress biom…
View article: A sulfated polyphenols-rich extract from Sabal yapa exhibits antitumor activities in Ehrlich ascites carcinoma
A sulfated polyphenols-rich extract from Sabal yapa exhibits antitumor activities in Ehrlich ascites carcinoma Open
Cancer is the second leading cause of mortality accounting for one in every six deaths globally. Plant secondary metabolites, among them polyphenols, represent an effective and much safer alternative approach to the currently available med…
View article: Synthesis and biological activity on IBD virus of diverse heterocyclic systems derived from 2-cyano-<i>N</i>'-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)acetohydrazide
Synthesis and biological activity on IBD virus of diverse heterocyclic systems derived from 2-cyano-<i>N</i>'-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)acetohydrazide Open
A 2-cyano-N'-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)ethanohydrazide (3) was synthesized in 87% yield via condensation of 3-formyl-2-oxoquinoline (1) with 2-cyanoethanohydrazide (2). The titled compound was t…
View article: Epigallocatechin gallate-capped gold nanoparticles enhanced the tumor suppressors let-7a and miR-34a in hepatocellular carcinoma cells
Epigallocatechin gallate-capped gold nanoparticles enhanced the tumor suppressors let-7a and miR-34a in hepatocellular carcinoma cells Open
Epigallocatechin gallate (EGCG), major constituent of green tea, possesses antioxidant, antiviral, and anticancer activities. Gold nanoparticles (AuNPs) play an important role in drug delivery due to their stability, ease of surface functi…
View article: Epigallocatechin gallate-capped gold nanoparticles enhanced the tumor suppressors let-7a and miR-34a in hepatocellular carcinoma cells
Epigallocatechin gallate-capped gold nanoparticles enhanced the tumor suppressors let-7a and miR-34a in hepatocellular carcinoma cells Open
Epigallocatechin gallate (EGCG), major constituent of green tea, possesses antioxidant, antiviral, and anticancer activities. Gold nanoparticles (AuNPs) play an important role in drug delivery due to their stability, ease of surface functi…
View article: TOXICOLOGICAL AND BIOCHEMICAL EFFECTS OF PRECOCENE II AGAINST COTTON LEAFWORM, SPODOPTERA LITTORALIS (BOISD.)
TOXICOLOGICAL AND BIOCHEMICAL EFFECTS OF PRECOCENE II AGAINST COTTON LEAFWORM, SPODOPTERA LITTORALIS (BOISD.) Open
he cotton leafworm, Spodoptera littoralis (Boisd.) is very polyphagous insect against the most economic plants all over the world.The traditional synthetic chemical insecticides had dramatic effect on the living organisms including man.Ant…
View article: Synthesis, Characterization and Optimization of PCL ˗ based Nanocapsules for Delivery of Anticancer Chemotheraputic Drug
Synthesis, Characterization and Optimization of PCL ˗ based Nanocapsules for Delivery of Anticancer Chemotheraputic Drug Open
Nanocapsules based drug delivery system has provided an efficient tools in cancer treatment in recent times. The toxicity of anticancer drugs can be decreased through nano-encapsulation using polymeric nanocapsules. This study aimed to syn…
View article: Detection of Y-Chromosome microdeletions in Egyptian infertile males
Detection of Y-Chromosome microdeletions in Egyptian infertile males Open
The major genetic causes in male infertility are chromosomal abnormalities and Y chromosomal microdeletions (YCMs). YCMs occur in approximately 15% of azoospermic patients and 10% of severe oligospermic patients. These microdeletions lead …
View article: Chemical composition and protective role of Pulicaria undulata (L.) C.A. Mey. subsp. undulata against gastric ulcer induced by ethanol in rats
Chemical composition and protective role of Pulicaria undulata (L.) C.A. Mey. subsp. undulata against gastric ulcer induced by ethanol in rats Open
Pulicaria undulata subsp. undulata (Family; Asteraceae) is a medicinal plant used to treat inflammation. The objective of this study is to explore the protective effect of the ethanol extract of P. undulata subsp. u…
View article: The effect of orientation of the lateral methyl substituent on the mesophase behaviour of 4-alkoxyphenylazo aryl benzoates
The effect of orientation of the lateral methyl substituent on the mesophase behaviour of 4-alkoxyphenylazo aryl benzoates Open
Two homologous series of 4-alkoxyphenylazo 4ʹ-(2ʺ- (and 3ʺ-) methyl-) 4ʹ-substituted benzoates (IIna–f and IIIna–f, six series each) were prepared and investigated. Within each series, the …
View article: The relation between glutathione S-Transferase M1 null-genotype and cardiac problems in beta-thalassemia.
The relation between glutathione S-Transferase M1 null-genotype and cardiac problems in beta-thalassemia. Open
This work was carried out to investigate the role of Glutathione S-Transferase M1 (GSTM1) null genotype frequency in prognosis of β-thalassemia, and to detect the correlation between GSTM1 null genotype and appearance of cardiac complicati…
View article: Biochemical and phytochemical studies on Balanities aegyptiaca fruits
Biochemical and phytochemical studies on Balanities aegyptiaca fruits Open
Objectives: Phytochemical screeninig of Balanities aegyptiaca (B.a.) extract and invitro determination of some biochemical effects. Methods: preparation of defatted Balanities aegyptiaca total extract, it's characterization was done throug…
View article: The effect of inversion of the ester group on the mesophase behaviour of some azo/ester compounds
The effect of inversion of the ester group on the mesophase behaviour of some azo/ester compounds Open
Five homologous series of 4-substituted phenyl 4′-(4″-alkoxy phenylazo) benzoates (Ina–−e) were prepared in which, within each homologous series, the length of the terminal alkoxy group varies…