Ali K. Albuhadily
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View article: Astrocyte response in Alzheimer’s disease: Good or bad?
Astrocyte response in Alzheimer’s disease: Good or bad? Open
Alzheimer's disease (AD) is the most common age-associated neurodegenerative disease globally. The pathogenesis of AD is related to the progressive neuronal apoptosis due to progressive accumulation of extracellular amyloid beta (Aβ) pepti…
View article: Differential Roles of Angiotensin A and Alamandine in Parkinson's Disease: A Therapeutic Perspective on Nonclassical RAS Pathways
Differential Roles of Angiotensin A and Alamandine in Parkinson's Disease: A Therapeutic Perspective on Nonclassical RAS Pathways Open
Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive neurodegeneration of dopaminergic neurons (DNs) in the substantia nigra (SN). PD neuropathology is mainly related to inflammation, mitochondri…
View article: Alzheimer disease: Amyloid peptide controversies and challenges of anti-Aβ immunotherapy
Alzheimer disease: Amyloid peptide controversies and challenges of anti-Aβ immunotherapy Open
View article: Monkeypox virus and type 1 diabetes: a molecular insight into inflammatory signaling and β-cell autoimmunity
Monkeypox virus and type 1 diabetes: a molecular insight into inflammatory signaling and β-cell autoimmunity Open
The current worldwide pandemic of monkeypox (MPXV) elicited apprehensions over its possible long-term health ramifications. Recent data indicate a potential association between MPXV infection and the onset of autoimmune disorders, such as …
View article: Targeting of the PI3 K/AKT/GSK3β Pathway in Parkinson's Disease: A Therapeutic Blueprint
Targeting of the PI3 K/AKT/GSK3β Pathway in Parkinson's Disease: A Therapeutic Blueprint Open
View article: Unlocking Alzheimer’s Disease: The Role of BDNF Signaling in Neuropathology and Treatment
Unlocking Alzheimer’s Disease: The Role of BDNF Signaling in Neuropathology and Treatment Open
View article: Epilepsy and autophagy modulators: a therapeutic split
Epilepsy and autophagy modulators: a therapeutic split Open
Epilepsy is a neurological disease characterized by repeated unprovoked seizure. Epilepsy is controlled by anti-epileptic drugs (AEDs); however, one third of epileptic patients have symptoms that are not controlled by AEDs in a condition c…
View article: The janus face of astrocytes in multiple sclerosis: Balancing protection and pathology
The janus face of astrocytes in multiple sclerosis: Balancing protection and pathology Open
View article: Glutamatergic dysfunction in neurodegenerative diseases focusing on Parkinson's disease: Role of glutamate modulators
Glutamatergic dysfunction in neurodegenerative diseases focusing on Parkinson's disease: Role of glutamate modulators Open
View article: Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition
Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition Open
Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau …
View article: The Peripheral Amyloid-β Nexus: Connecting Alzheimer’s Disease with Atherosclerosis through Shared Pathophysiological Mechanisms
The Peripheral Amyloid-β Nexus: Connecting Alzheimer’s Disease with Atherosclerosis through Shared Pathophysiological Mechanisms Open
View article: Amyloid-β and heart failure in Alzheimer’s disease: the new vistas
Amyloid-β and heart failure in Alzheimer’s disease: the new vistas Open
Alzheimer’s disease (AD) is the most common cause of dementia and represents 75% of all dementia types. AD neuropathology is due to the progressive deposition of extracellular amyloid-beta (A β ) peptide and intracellular hyperphosphorylat…
View article: The role of autophagy in Graves disease: knowns and unknowns
The role of autophagy in Graves disease: knowns and unknowns Open
Graves disease (GD), an autoimmune disease affects the thyroid gland, results in hyperthyroidisms and goiter. The main cause of GD is not clearly defined; however, stimulating autoantibodies for thyroid stimulating hormone receptor (TSHR) …
View article: The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective
The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective Open
Epilepsy is a neurological disease characterized by unprovoked recurrent epileptic seizures. Temporal lobe epilepsy (TLE) is the commonest type of focal epilepsy in adults that resist to the conventional anti-seizure medications (ASMs). In…
View article: Alterations in the Processing of Platelet <scp>APP</scp> (Amyloid Beta Precursor Protein) in Alzheimer Disease: The Possible Nexus
Alterations in the Processing of Platelet <span>APP</span> (Amyloid Beta Precursor Protein) in Alzheimer Disease: The Possible Nexus Open
Alzheimer's disease (AD) is the most common neurodegenerative disease associated with the development of dementia. The hallmarks of AD neuropathology are accumulations of amyloid peptide (Aβ) and neurofibrillary tangles (NFTs). Aβ is deriv…
View article: Neurosteroids-Mediated Neuroprotection via mTORC1/AMPK/BDNF Signaling Pathway in Alzheimer's disease
Neurosteroids-Mediated Neuroprotection via mTORC1/AMPK/BDNF Signaling Pathway in Alzheimer's disease Open
View article: Molecular Signaling Pathways of Quercetin in Alzheimer’s Disease: A Promising Arena
Molecular Signaling Pathways of Quercetin in Alzheimer’s Disease: A Promising Arena Open
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by cognitive impairment and memory deficit. Even with extensive research and studies, presently, there is no effective treatment for the management of AD. Besides, most …
View article: The Compelling Role of Brain‐Derived Neurotrophic Factor Signaling in Multiple Sclerosis: Role of <scp>BDNF</scp> Activators
The Compelling Role of Brain‐Derived Neurotrophic Factor Signaling in Multiple Sclerosis: Role of <span>BDNF</span> Activators Open
Brain‐derived neurotrophic factor (BDNF) is a neurotrophin, acting as a neurotrophic signal and neuromodulator in the central nervous system (CNS). BDNF is synthesized from its precursor proBDNF within the CNS and peripheral tissues. Throu…
View article: The role of statins in amyotrophic lateral sclerosis: protective or not?
The role of statins in amyotrophic lateral sclerosis: protective or not? Open
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of motor neurons characterized by muscle weakness, muscle twitching, and muscle wasting. ALS is regarded as the third-most frequent neurodegenerative disease, s…
View article: The potential role of brain renin‐angiotensin system in the neuropathology of Parkinson disease: Friend, foe or turncoat?
The potential role of brain renin‐angiotensin system in the neuropathology of Parkinson disease: Friend, foe or turncoat? Open
Parkinson disease (PD) is one of the most common neurodegenerative diseases of the brain. Of note, brain renin‐angiotensin system (RAS) is intricate in the PD neuropathology through modulation of oxidative stress, mitochondrial dysfunction…
View article: The functional and molecular roles of p75 neurotrophin receptor (p75<sup>NTR</sup>) in epilepsy
The functional and molecular roles of p75 neurotrophin receptor (p75<sup>NTR</sup>) in epilepsy Open
Epilepsy is a chronic neurological disorder manifested by recurring unprovoked seizures resulting from an imbalance in the inhibitory and excitatory neurotransmitters in the brain. The process of epileptogenesis involves a complex interpla…
View article: The efficacy and safety of Acetaminophen for pain relief
The efficacy and safety of Acetaminophen for pain relief Open
Acetaminophen is a non-narcotic analgesic used as an analgesic and antipyretic. Acetaminophen is used for mild to moderate pain; its efficacy is low as analgesic as compared to non-steroidal anti-inflammatory drugs (NSAIDs) as it has no an…
View article: Sleep disorders cause Parkinson's disease or the reverse is true: Good GABA good night
Sleep disorders cause Parkinson's disease or the reverse is true: Good GABA good night Open
Background Parkinson's disease (PD) is a progressive neurodegenerative brain disease due to degeneration of dopaminergic neurons (DNs) presented with motor and non‐motor symptoms. PD symptoms are developed in response to the disturbance of…
View article: Therapeutic Potential Effect of Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors in Parkinson Disease: Exploring an Overlooked Avenue
Therapeutic Potential Effect of Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors in Parkinson Disease: Exploring an Overlooked Avenue Open
Parkinson’s disease (PD) is a progressive neurodegenerative disease of the brain due to degeneration of dopaminergic neurons in the substantia nigra (SN). Glycogen synthase kinase 3 beta (GSK-3β) is implicated in the pathogenesis of PD. Th…
View article: Role of brain renin–angiotensin system in depression: A new perspective
Role of brain renin–angiotensin system in depression: A new perspective Open
Depression is a mood disorder characterized by abnormal thoughts. The pathophysiology of depression is related to the deficiency of serotonin (5HT), which is derived from tryptophan (Trp). Mitochondrial dysfunction, oxidative stress, and n…
View article: Celiprolol and sympatho‐immune interface in <scp>COVID</scp>‐19
Celiprolol and sympatho‐immune interface in <span>COVID</span>‐19 Open
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
View article: Antidepressants and type 2 diabetes: highways to knowns and unknowns
Antidepressants and type 2 diabetes: highways to knowns and unknowns Open
Type 2 diabetes (T2D) is a metabolic disease caused by the development of insulin resistance (IR), relative insulin deficiency, and hyperglycemia. Hyperglycemia-induced neurochemical dysregulation activates the progression of depression in…
View article: SARS‐CoV‐2 induced HDL dysfunction may affect the host's response to and recovery from COVID‐19
SARS‐CoV‐2 induced HDL dysfunction may affect the host's response to and recovery from COVID‐19 Open
Introduction Covid‐19 is linked with the development of cardio‐metabolic disorders, including dyslipidemia, dysregulation of high‐density lipoprotein (HDL), and low‐density lipoprotein (LDL). Furthermore, SARS‐Co‐2 infection is associated …
View article: Mixed storm in SARS‐CoV‐2 infection: A narrative review and new term in the Covid‐19 era
Mixed storm in SARS‐CoV‐2 infection: A narrative review and new term in the Covid‐19 era Open
Coronavirus disease 2019 (Covid‐19) is caused by a novel severe acute respiratory syndrome coronavirus virus type 2 (SARS‐CoV‐2) leading to the global pandemic worldwide. Systemic complications in Covid‐19 are mainly related to the direct …
View article: Is sitagliptin effective for SARS-CoV-2 infection: false or true prophecy?
Is sitagliptin effective for SARS-CoV-2 infection: false or true prophecy? Open
Coronavirus disease 2019 (Covid-19) is caused by severe acute respiratory syndrome type 2 (SARS-CoV-2). Covid-19 is characterized by hyperinflammation, oxidative stress, and multi-organ injury (MOI) such as acute lung injury (ALI) and acut…