Mohamed M. Ali
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View article: Proposed Definitions and Clinical Recommendations for the Management of Weight Recurrence, Partial Response, and Nonresponse Following Metabolic and Bariatric Surgery
Proposed Definitions and Clinical Recommendations for the Management of Weight Recurrence, Partial Response, and Nonresponse Following Metabolic and Bariatric Surgery Open
Background Weight recurrence (WR), partial response, and nonresponse following metabolic and bariatric surgery (MBS) remain poorly defined. This lack of standardization hinders timely diagnosis, clinical management, and outcomes research. …
View article: Participant Satisfaction, Effectiveness, and Safety With a Novel Dual-Applicator Cryolipolysis System: A Prospective, Multicountry Study
Participant Satisfaction, Effectiveness, and Safety With a Novel Dual-Applicator Cryolipolysis System: A Prospective, Multicountry Study Open
BACKGROUND Cryolipolysis is an effective, well-tolerated noninvasive subcutaneous fat reduction treatment. OBJECTIVE Assess participant satisfaction, effectiveness, and safety of a dual-applicator cryolipolysis system that can deliver simu…
View article: Adiposome Proteomics Uncover Molecular Signatures of Cardiometabolic Risk in Obese Individuals
Adiposome Proteomics Uncover Molecular Signatures of Cardiometabolic Risk in Obese Individuals Open
Background: Adipose-derived extracellular vesicles (adiposomes) are emerging as key mediators of inter-organ communication, yet their molecular composition and role in obesity-related pathophysiology remain underexplored. This study integr…
View article: Pathways for accelerated bacterial spore killing with ohmic heating
Pathways for accelerated bacterial spore killing with ohmic heating Open
The mechanism by which ohmic heating (OH) accelerates bacterial spore killing compared to conventional heating (CH) is unclear. This study used genetically modified Bacillus subtilis spores to investigate OH’s impact on specific components…
View article: Mitral Valve Infective Endocarditis Complicated by Aortic Root Abscess: A Rare and Fatal Progression
Mitral Valve Infective Endocarditis Complicated by Aortic Root Abscess: A Rare and Fatal Progression Open
Infective endocarditis (IE) is a life-threatening condition associated with high morbidity and mortality. Although aortic root abscesses are most commonly associated with aortic valve involvement, this case illustrates that mitral valve en…
View article: MMP-8, IL-6, and IL-1;beta;: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis
MMP-8, IL-6, and IL-1;beta;: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis Open
Periodontitis, Salivary biomarkers, Saliva, Interleukin 1beta, Interleukin 6, Matrix metalloproteinases 8.
View article: Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk
Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk Open
BACKGROUNDObesity, a growing health concern, often leads to metabolic disturbances, systemic inflammation, and vascular dysfunction. Emerging evidence suggests that adipose tissue-derived extracellular vesicles (adiposomes) may propagate o…
View article: Performance of Automatic Urine Analyzer Compared with Manual Microscopy in Urinary Tract Infection Cases in a Tertiary Care Hospital
Performance of Automatic Urine Analyzer Compared with Manual Microscopy in Urinary Tract Infection Cases in a Tertiary Care Hospital Open
Objectives: This study aimed to assess and compare the results of automated urine analyzers and manual urine analysis in the evaluation of urinary tract infections (UTIs) at Pakistan Navy Shifa Hospital Karachi. Study Design and Setting: A…
View article: Insight into the lifestyle of young people with chronic liver disease
Insight into the lifestyle of young people with chronic liver disease Open
The impact of chronic liver disease (CLD) in young people on lifestyle is poorly explored. One hundred four young people (20.51 years, male 44%), including 37% with autoimmune liver disease and 19% post‐liver transplantation, completed an …
View article: Formulation and evaluation of mucoadhesive gastro-retentive tablets of domperidone
Formulation and evaluation of mucoadhesive gastro-retentive tablets of domperidone Open
Objective: This study was aimed at the formation and evaluation of the mucoadhesive gastro-retentive tablet of domperidone to overcome the drawbacks related to the oral administration of drugs. These gastro retentive formulations stay in t…
View article: Evaluating tourniquet duration in total knee replacement: short-term outcomes of short versus long durations, a randomized controlled trial
Evaluating tourniquet duration in total knee replacement: short-term outcomes of short versus long durations, a randomized controlled trial Open
Background Total knee arthroplasty (TKA) is an effective treatment for severe osteoarthritis. We aim to compare the advantages and disadvantages related to the duration of tourniquet application in TKA surgeries. Patients and methods This …
View article: Transulnar versus Transradial Approach for Percutaneous Coronary Procedures
Transulnar versus Transradial Approach for Percutaneous Coronary Procedures Open
Background: Transradial access (TRA) for percutaneous coronary procedures has become a widely adopted approach, with proven safety and feasibility. However, the transulnar approach remains a promising alternative. This study aimed to compa…
View article: Adiposomes from Obese-Diabetic Individuals Promote Endothelial Dysfunction and Loss of Surface Caveolae
Adiposomes from Obese-Diabetic Individuals Promote Endothelial Dysfunction and Loss of Surface Caveolae Open
Glycosphingolipids (GSLs) are products of lipid glycosylation that have been implicated in the development of cardiovascular diseases. In diabetes, the adipocyte microenvironment is characterized by hyperglycemia and inflammation, resultin…
View article: CHA2DS2 VASc score and its correlation with TIMI flow count in patients with STEMI Undergoing primary PCI
CHA2DS2 VASc score and its correlation with TIMI flow count in patients with STEMI Undergoing primary PCI Open
Background: CHA2DS2-VASc score is used to predict the risk of thrombo-embolic events in patients with AF.In this study, CHA2DS2-VASc score was investigated to show its correlation with TIMI flow count among patients with ST elevation myoca…
View article: Ultrasound-guided fascia iliaca block versus quadratus lumborum block for perioperative analgesia in patients undergoing hip surgery. A randomised controlled trial
Ultrasound-guided fascia iliaca block versus quadratus lumborum block for perioperative analgesia in patients undergoing hip surgery. A randomised controlled trial Open
Introduction Femoral neck fractures are common orthopaedic fractures, especially in old age, and they represent a life-threatening condition requiring surgical intervention. In this study, we aimed to compare 2 regional techniques used to …
View article: Racial Disparity in Anthracycline-induced Cardiotoxicity in Breast Cancer Patients
Racial Disparity in Anthracycline-induced Cardiotoxicity in Breast Cancer Patients Open
Breast cancer has become the most common cancer in the US and worldwide. While advances in early detection and treatment have resulted in a 40% reduction in breast cancer mortality, this reduction has not been achieved uniformly among raci…
View article: Obesity-Associated Vitamin D Deficiency Correlates with Adipose Tissue DNA Hypomethylation, Inflammation, and Vascular Dysfunction
Obesity-Associated Vitamin D Deficiency Correlates with Adipose Tissue DNA Hypomethylation, Inflammation, and Vascular Dysfunction Open
Vitamin D (VD) deficiency is a hallmark of obesity and vascular dysfunction. We sought to test the hypothesis that VD deficiency may contribute to obesity-related vascular dysfunction by inducing adipokine hypomethylation and augmented exp…
View article: DNA Hypomethylation as a Potential Link between Excessive Alcohol Intake and Cardiometabolic Dysfunction in Morbidly Obese Adults
DNA Hypomethylation as a Potential Link between Excessive Alcohol Intake and Cardiometabolic Dysfunction in Morbidly Obese Adults Open
A large percentage of obese patients in the United States suffer a comorbid substance use disorder, mainly alcohol use. Alcohol consumption interferes with the absorption of dietary methyl donors such as folate required for the one-carbon …
View article: CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults
CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults Open
CD147 is a glycoprotein that stimulates the production of matrix metalloproteinases (MMPs), known contributors to cardiovascular risk. The activity of CD147 protein depends on its glycosylation. However, it is unclear whether CD147 protein…
View article: Adipose Tissue Hypoxia Correlates with Adipokine Hypomethylation and Vascular Dysfunction
Adipose Tissue Hypoxia Correlates with Adipokine Hypomethylation and Vascular Dysfunction Open
Obesity is characterized by the accumulation of dysfunctional adipose tissues, which predisposes to cardiometabolic diseases. Our previous in vitro studies demonstrated a role of hypoxia in inducing adipokine hypomethylation in adipocytes.…
View article: High Glucose and Advanced Glycation End Products Induce CD147-Mediated MMP Activity in Human Adipocytes
High Glucose and Advanced Glycation End Products Induce CD147-Mediated MMP Activity in Human Adipocytes Open
Basigin (CD147) is a transmembrane glycoprotein that regulates several physiological processes, including the production and activity of matrix metalloproteinases (MMPs). The activity of CD147 depends mainly on its glycosylation, which var…