Menna R. Clatworthy
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View article: Childhood brain tumours instruct cranial haematopoiesis and immunotolerance
Childhood brain tumours instruct cranial haematopoiesis and immunotolerance Open
Recent research has revealed a remarkable role for immunosurveillance in healthy and diseased brains, dispelling the notion that this organ is a passive immune-privileged site 1–3 . Better understanding of how this immunosurveillance opera…
View article: Iterative Bleaching Extends Multiplexity (IBEX) Knowledge-Base
Iterative Bleaching Extends Multiplexity (IBEX) Knowledge-Base Open
The Iterative Bleaching Extends Multiplexity (IBEX) imaging method is an iterative immunolabeling and chemical bleaching method that enables highly multiplexed imaging of diverse tissues. Development of the IBEX method and related software…
View article: Intestinal challenges shape the polarisation of protective dural memory CD4 T cells
Intestinal challenges shape the polarisation of protective dural memory CD4 T cells Open
The meninges house several innate and adaptive immune cell populations 1–3 . These predominantly localise within the dura mater and include gut-derived IgA-secreting plasma cells 4 . Whether T cell adaptive memory in the dura is similarly …
View article: Figure S7 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S7 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 7
View article: Figure S5 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S5 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 5
View article: Figure S3 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S3 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 3
View article: Figure S2 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S2 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 2
View article: Figure S10 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S10 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 10
View article: Data from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Data from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Tumor-associated macrophages (TAM) are a universal feature of cancers but variably influence outcomes and treatment responses. In this study, we used a photoconvertible mouse to distinguish newly entering, monocyte-derived TAMs (mdTAM) tha…
View article: Figure S8 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S8 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 8
View article: Supplementary table 1 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Supplementary table 1 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Antibodies and reagents
View article: Figure S1 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S1 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 1
View article: Figure S6 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S6 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 6
View article: Figure S4 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S4 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 4
View article: Figure S9 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S9 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 9
View article: Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection
Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection Open
Lymphatic vessels maintain tissue fluid homeostasis and modulate inflammation, yet their spatial organization and molecular identity in the healthy human kidney, and how these change during chronic transplant rejection, remain poorly defin…
View article: Mapping and reprogramming human tissue microenvironments with MintFlow
Mapping and reprogramming human tissue microenvironments with MintFlow Open
Tissue microenvironments reprogram local cellular states in disease, yet current computational spatial methods remain descriptive and do not simulate tissue perturbation. We present MintFlow, a generative AI algorithm that learns how the t…
View article: Temporal multi-omics analysis of COVID-19 in end-stage kidney disease
Temporal multi-omics analysis of COVID-19 in end-stage kidney disease Open
Patients with end-stage kidney disease (ESKD) are at high risk of severe COVID-19. We performed longitudinal single-cell immune profiling of ESKD patients with COVID-19. Transcriptome, surface proteome, and immunoreceptor sequencing data w…
View article: <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
<i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Tumor-associated macrophages (TAM) are a universal feature of cancers but variably influence outcomes and treatment responses. In this study, we used a photoconvertible mouse to distinguish newly entering, monocyte-derived TAMs (mdTAM) tha…
View article: Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells following acute coronary syndrome
Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells following acute coronary syndrome Open
Targeting inflammation in atherosclerotic cardiovascular disease remains a major unmet need. Low-dose interleukin-2 (IL-2 LD ) selectively increases regulatory T (T reg ) cell numbers in patients with coronary artery disease. Here we combi…
View article: Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson’s Disease
Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson’s Disease Open
We investigated the role of inflammation in the pathogenesis of prodromal Parkinson’s Disease (PD), performing single-cell RNAseq analysis of cerebrospinal fluid (CSF) and blood from 111 individuals, comparing control subjects with early p…
View article: The IBEX Imaging Knowledge-Base: A Community Resource Enabling Adoption and Development of Immunofluoresence Imaging Methods
The IBEX Imaging Knowledge-Base: A Community Resource Enabling Adoption and Development of Immunofluoresence Imaging Methods Open
The iterative bleaching extends multiplexity (IBEX) Knowledge-Base is a central portal for researchers adopting IBEX and related 2D and 3D immunofluorescence imaging methods. The design of the Knowledge-Base is modeled after efforts in the…
View article: The IBEX Imaging Knowledge-Base: A Community Resource Enabling Adoption and Development of Immunofluoresence Imaging Methods
The IBEX Imaging Knowledge-Base: A Community Resource Enabling Adoption and Development of Immunofluoresence Imaging Methods Open
The iterative bleaching extends multiplexity (IBEX) Knowledge-Base is a central portal for researchers adopting IBEX and related 2D and 3D immunofluorescence imaging methods. The design of the Knowledge-Base is modeled after efforts in the…
View article: Microvascular aberrations found in human polycystic kidneys are an early feature in a <i>Pkd1</i> mutant mouse model
Microvascular aberrations found in human polycystic kidneys are an early feature in a <i>Pkd1</i> mutant mouse model Open
Therapies targeting blood vessels hold promise for autosomal dominant polycystic kidney disease (ADPKD), the most common inherited disorder causing kidney failure. However, the onset and nature of kidney vascular abnormalities in ADPKD are…
View article: The IBEX Knowledge-Base: A central resource for multiplexed imaging techniques
The IBEX Knowledge-Base: A central resource for multiplexed imaging techniques Open
Multiplexed imaging is a powerful approach in spatial biology, although it is complex, expensive and labor-intensive. Here, we present the IBEX Knowledge-Base, a central resource for reagents, protocols and more, to enhance knowledge shari…
View article: Multifaceted B-cell response to transient HIV viraemia in elite controllers
Multifaceted B-cell response to transient HIV viraemia in elite controllers Open
Chronic HIV infection drives B-cell dysfunction associated with the accumulation of tissue-like memory (TLMs) and activated memory B cells (MBCs) but decline in resting memory B cells. TLMs express multiple inhibitory receptors and lack re…