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View article: An Intrinsically Disordered Region of Histone Demethylase KDM5A Activates Catalysis Through Interactions With the Nucleosomal Acidic Patch and DNA
An Intrinsically Disordered Region of Histone Demethylase KDM5A Activates Catalysis Through Interactions With the Nucleosomal Acidic Patch and DNA Open
Lysine demethylase 5A (KDM5A) plays a key role in the regulation of chromatin accessibility by catalyzing the removal of trimethyl marks on histone H3K4 (H3K4me3). KDM5A is also an oncogenic driver, with overexpression of KDM5A observed in…
View article: An intrinsically disordered region of histone demethylase KDM5A activates catalysis through interactions with the nucleosomal acidic patch and DNA
An intrinsically disordered region of histone demethylase KDM5A activates catalysis through interactions with the nucleosomal acidic patch and DNA Open
Lysine demethylase 5A (KDM5A) plays a key role in the regulation of chromatin accessibility by catalyzing the removal of trimethyl marks on histone H3K4 (H3K4me3). KDM5A is also an oncogenic driver, with overexpression of KDM5A observed in…
View article: Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance
Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance Open
Alteration of antibiotic binding sites through modification of ribosomal RNA (rRNA) is a common form of resistance to ribosome-targeting antibiotics. The rRNA-modifying enzyme Cfr methylates an adenosine nucleotide within the peptidyl tran…
View article: Author response: Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance
Author response: Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Alteratio…
View article: Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance
Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance Open
Alteration of antibiotic binding sites through modification of ribosomal RNA (rRNA) is a common form of resistance to ribosome-targeting antibiotics. The rRNA-modifying enzyme Cfr methylates an adenosine nucleotide within the peptidyl tran…
View article: Higher-order inter-chromosomal hubs shape 3-dimensional genome organization in the nucleus
Higher-order inter-chromosomal hubs shape 3-dimensional genome organization in the nucleus Open
Eukaryotic genomes are packaged into a 3-dimensional structure in the nucleus of each cell. There are currently two distinct views of genome organization that are derived from different technologies. The first view, derived from genome-wid…