Ali Raza Awan
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View article: Altered expression and mutations in cell cycle genes CCND1, CDK4, CDKN2B and TP53 are associated with Pakistani breast cancer patients
Altered expression and mutations in cell cycle genes CCND1, CDK4, CDKN2B and TP53 are associated with Pakistani breast cancer patients Open
Background: Breast cancer impacts nearly one-third of women globally during their lifetime, with the risk increasing in those exhibiting elevated gene expression linked to genetic polymorphisms. In Pakistan, breast cancer ranks among the t…
View article: SOCIAL MEDIA ADDICTION AND CYBERBULLYING PERPETRATION: A COMPARATIVE STUDY OF GENDER IN PAKISTAN
SOCIAL MEDIA ADDICTION AND CYBERBULLYING PERPETRATION: A COMPARATIVE STUDY OF GENDER IN PAKISTAN Open
Background: The rapid growth of social media has transformed communication, education, and business interactions globally. However, its overuse is increasingly linked to maladaptive behaviors, particularly among youth. Cyberbullying perpet…
View article: A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons Open
Repeat expansions in C9orf72 are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. Repeat-associated non-AUG (RAN) translation generates neurotoxic dipeptide repeat proteins (DPRs). To study endogenous DPR…
View article: Disinfectants are effective in controlling bacterial contaminants in swimming pool and pond waters in Lahore City, Punjab, Pakistan
Disinfectants are effective in controlling bacterial contaminants in swimming pool and pond waters in Lahore City, Punjab, Pakistan Open
Swimming pools and pond waters may contain microbial contamination that could be a source of public health hazards. Waterborne bacteria from human or animal excrements or the environment can contaminate swimming pools and ponds. Unhygienic…
View article: Generation of <i>C9orf72<sup>h370</sup></i>mice, an intron 1 humanised <i>C9orf72</i> repeat-expansion knock-in model
Generation of <i>C9orf72<sup>h370</sup></i>mice, an intron 1 humanised <i>C9orf72</i> repeat-expansion knock-in model Open
An autosomal dominant GGGGCC repeat expansion in intron 1 of the C9orf72 gene is the most common genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we set out to engineer a gene targeted mous…
View article: Optimization of suspension culture of adapted baby hamster kidney cells in a bioreactor for maximum cell density
Optimization of suspension culture of adapted baby hamster kidney cells in a bioreactor for maximum cell density Open
View article: Validity Profile and Practically Biological Teaching Structures Based on Local Potenties BIOLA PJBL High Level and Enrichment Program
Validity Profile and Practically Biological Teaching Structures Based on Local Potenties BIOLA PJBL High Level and Enrichment Program Open
Biology based on local potential Bioecology (BIOLA) PjBL High Level, is a promoter of a valid and practical enrichment program for SMAN pupils in Saparua Island. Products were developed in the form of RPPs, teaching materials, and Students…
View article: 3D modeling of thermostable xylanase from Thermotoga naphthophila a member of GH10 family: characterization studies of recombinant xylanase
3D modeling of thermostable xylanase from Thermotoga naphthophila a member of GH10 family: characterization studies of recombinant xylanase Open
The current study was planned keeping in view the significance, industrial impact and import of xylanase to Pakistan. In this study, a thermostable recombinant xylanase from Thermotoga naphthophila was produced and characterized. The PCR p…
View article: Learning Creative Problem-Solving Model With Guided Inquiry Strategy to Improve Students' Concept Mastery
Learning Creative Problem-Solving Model With Guided Inquiry Strategy to Improve Students' Concept Mastery Open
Categories of learning outcomes include acceptance, response, assessment, organization, and pattern formation. Thus, the essence of learning is a change in thinking that affects behaviour. The results of interviews with teachers at SMA Kar…
View article: Disentangling river and swamp buffalo genetic diversity: initial insights from the 1000 Buffalo Genomes Project
Disentangling river and swamp buffalo genetic diversity: initial insights from the 1000 Buffalo Genomes Project Open
More people in the world depend on water buffalo for their livelihoods than on any other domesticated animals, but its genetics is still not extensively explored. The 1000 Buffalo Genomes Project (1000BGP) provides genetic resources for gl…
View article: MicroRNAs hsa-miR-222-3p, hsa-let-7b-5p, and hsa-let-7f-5p Regulate Their Putative Target Genes HMGA1 and CDKN1B in Pakistani Breast Cancer Patients
MicroRNAs hsa-miR-222-3p, hsa-let-7b-5p, and hsa-let-7f-5p Regulate Their Putative Target Genes HMGA1 and CDKN1B in Pakistani Breast Cancer Patients Open
View article: Improvement in Long Term Bonding and Mechanical Performance by Using Glass Concrete in Combination with Xanthan Gum Exposed to Harsh Environment
Improvement in Long Term Bonding and Mechanical Performance by Using Glass Concrete in Combination with Xanthan Gum Exposed to Harsh Environment Open
Concrete is the mostly used construction material composed of a mixture of cement, water, aggregates (such as sand, gravel, or crushed stone), and often additional additives or admixtures. It is widely used in the construction industry for…
View article: Molecular Identification of Predatory Birds Through Analysis of Mitochondrial ND2 Gene
Molecular Identification of Predatory Birds Through Analysis of Mitochondrial ND2 Gene Open
Mutations in mitochondrial DNA (mtDNA) have been associated with many pathological conditions including cardiovascular diseases.In the present study, we have evaluated the mutations in the mitochondrial tRNA genes for leucine, threonine an…
View article: Quantification and characterization of microplastics (MPs) pollution in peri-uburban agricultural lands of Lahore, Pakistan
Quantification and characterization of microplastics (MPs) pollution in peri-uburban agricultural lands of Lahore, Pakistan Open
Microplastics (MPs) contaminate every conceivable terrestrial and aquatic environment including high peaks and deep marine trenches. Agricultural lands alone are expected to receive plastic up to 23 times more than ocean basins. In this st…
View article: Preparation of purified vaccine from local isolate of foot and mouth disease virus and its immune response in bovine calves
Preparation of purified vaccine from local isolate of foot and mouth disease virus and its immune response in bovine calves Open
Foot and Mouth Disease (FMD) is globally pandemic which badly affect the economics of livestock based countries like Pakistan. There are different types of Foot and Mouth Disease Virus (FMDV) among these types O is most prevalent in Pakist…
View article: Expression Profiling of microRNAs hsa-222-3p, hsa-let-7b-5p, hsa-let-7f-5p and their Putative Targets HMGA1 and CDKN1B Genes in Canine Mammary Tumor
Expression Profiling of microRNAs hsa-222-3p, hsa-let-7b-5p, hsa-let-7f-5p and their Putative Targets HMGA1 and CDKN1B Genes in Canine Mammary Tumor Open
Contribution YZ, LL and LSY designed the experiments and drafted the manuscript.LL, JHH and DLL executed the experiment.LQT
View article: Relationship between Body Weight and Linear Body Measurements in Pakistani Quail (Coturnix japonica PK)
Relationship between Body Weight and Linear Body Measurements in Pakistani Quail (Coturnix japonica PK) Open
AM and ARA planned the experiments.HJ provided the samples.AM, AS and WM interpreted the results.AM, FS
View article: Immuno-affinity chromatography for purification of IgG from hyper-immune sera raised against 146S fraction of Foot and Mouth Disease Virus for diagnostic purposes
Immuno-affinity chromatography for purification of IgG from hyper-immune sera raised against 146S fraction of Foot and Mouth Disease Virus for diagnostic purposes Open
Immunoaffinity chromatography (IAC) is a fundamental isolation and purification tool which is incorporated in a substantial range of therapeutic and diagnostic applications. This study has reappraised the usefulness of immunoaffinity chrom…
View article: In Vivo Evaluation of purD Gene Deleted Brucella abortus in Mice as Potential Vaccine Candidate for Control of Brucellosis
In Vivo Evaluation of purD Gene Deleted Brucella abortus in Mice as Potential Vaccine Candidate for Control of Brucellosis Open
Asiatic black bears (Ursus thibetanus laniger) are natural inhabitants of deciduous forests.They live solitary in their natural habitat.Their captive behaviour was studied by taking two Asiatic black bear pairs as study subjects in Lahore …
View article: Clinical, Hematological and Biochemical Manifestations Among Dengue Patients of Lahore Region
Clinical, Hematological and Biochemical Manifestations Among Dengue Patients of Lahore Region Open
Toxoplasmosis is a parasitic disease that is transmitted by a variety of routes, including the ingestion of raw or undercooked meat.It infects roughly one-third of the world's population and is caused by Toxoplasma gondii, an obligate intr…
View article: Evolutionary dynamics of topotype ME-SA/Ind-2001 of foot and mouth disease virus serotype-O in Pakistan: 2017-2022.
Evolutionary dynamics of topotype ME-SA/Ind-2001 of foot and mouth disease virus serotype-O in Pakistan: 2017-2022. Open
Observed mutations suggest potential challenges to current vaccination efficacy against FMD. This emphasizes enhanced FMD surveillance and demonstrates that tracking the emergence of the O/ME-SA/Ind-2001e lineage is important for determini…
View article: Whole-Genome Variants Discovery of FMD Virus Isolated from Cattle Population in Pakistan
Whole-Genome Variants Discovery of FMD Virus Isolated from Cattle Population in Pakistan Open
Foot-and-mouth disease (FMD) is extremely contagious and multispecies that has a severe impact on animal trade across the borders. FMD virus may cause epidemics resulting in devastation of livestock industry so, it’s worthy to explore the …
View article: Impact of Locally Characterized Protease from Geobacillus SBS 4S on the Growth of Poultry Bird
Impact of Locally Characterized Protease from Geobacillus SBS 4S on the Growth of Poultry Bird Open
Due to the expanding human population and subsequent developmental processes, it is crucial to evaluate habitats to design robust conservation strategies.We used maximum entropy modeling (MaxEnt) to identify suitable habitats for red fox (…
View article: Construction and Characterization of purD Gene Deleted Brucella abortus
Construction and Characterization of purD Gene Deleted Brucella abortus Open
This study was performed to evaluate the effects of organic acid and feed restriction intensity on the performance and immune response of broilers.For this purpose, 540 one-day-old male broilers of Ross 308 strain were grown in a 3×3 facto…
View article: Physical and Chemical Factors Affecting biomass and alpha toxin production of CLOSTRIDIUM PERFRINGENS TOXINOTYPE A
Physical and Chemical Factors Affecting biomass and alpha toxin production of CLOSTRIDIUM PERFRINGENS TOXINOTYPE A Open
Clostridium perfringens toxinotype A is one of the important causes of diarrhea/enterotoxaemia in small and large ruminants. Various vaccines have been used against it in Pakistan but all are imported. To muddle through frequent onset of d…
View article: Characterization of a Novel Recombinant β-Lactamase from Bacillus subtilis R5
Characterization of a Novel Recombinant β-Lactamase from Bacillus subtilis R5 Open
Current study deals with the characterization of recombinant β-lactamase from a locally isolated strain Bacillus subtilis R5.The study was an initial step for the fulfillment of commercial needs of β-lactamase in Pakistan.The 1 kb β-lactam…
View article: Polymorphism in MCM6-Gene Associated with Lactose Non-Persistence in Pakistani Patients
Polymorphism in MCM6-Gene Associated with Lactose Non-Persistence in Pakistani Patients Open
This study was aimed to investigate antibacterial activity of chemical constituents of Taraxacum officinale against foodborne pathogens.A total of 133 retail meat products were randomly purchased from different supermarkets.All samples wer…
View article: Serological Estimation, Molecular Detectionand Serotyping of Dengue Virus in Dengue Patientsof Lahore Region
Serological Estimation, Molecular Detectionand Serotyping of Dengue Virus in Dengue Patientsof Lahore Region Open
Dengue has become endemic in Pakistan, and increasing cases of dengue have been reported every year since 2006.The objective of the study was to serologically and molecularly diagnose dengue disease and to identify the circulating serotype…
View article: Combined epidemiological and genomic analysis of nosocomial SARS-CoV-2 infection early in the pandemic and the role of unidentified cases in transmission
Combined epidemiological and genomic analysis of nosocomial SARS-CoV-2 infection early in the pandemic and the role of unidentified cases in transmission Open
View article: Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 Open