Ali Ryan
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View article: P02 Uncovering the role of NAD(P)H quinone oxidoreductases in <i>Pseudomonas aeruginosa</i> : new avenues for antibiotic potentiators
P02 Uncovering the role of NAD(P)H quinone oxidoreductases in <i>Pseudomonas aeruginosa</i> : new avenues for antibiotic potentiators Open
Background Antimicrobial resistance (AMR) is a critical global health challenge, with Gram-negative pathogens such as Pseudomonas aeruginosa posing a major threat due to their multidrug resistance and clinical prevalence in hospital-acquir…
View article: Preparation, analysis and toxicity characterisation of the redox metabolites of the azo food dye tartrazine
Preparation, analysis and toxicity characterisation of the redox metabolites of the azo food dye tartrazine Open
Tartrazine (E102, FD&C; Yellow 5) is a vibrant yellow azo dye added to many processed foods. The safety of this ubiquitous chemical has not been fully elucidated, and it has been linked to allergic reactions and ADHD in some individuals. I…
View article: Synthesis and Initial Evaluation of a Novel Fluorophore for Selective FMDV 3C Protease Detection
Synthesis and Initial Evaluation of a Novel Fluorophore for Selective FMDV 3C Protease Detection Open
The development and evaluation of a Boc-AL(Boc)Q(Trt)-AMC fluorophore to detect 3C Protease, produced by Foot and Mouth Disease Virus (FMDV) is reported, with a view to a potential use as a rapid screen for FMDV infected livestock The pept…
View article: Corrigendum: Variant Signal Peptides of Vaccine Antigen, FHbp, Impair Processing Affecting Surface Localization and Antibody-Mediated Killing in Most Meningococcal Isolates
Corrigendum: Variant Signal Peptides of Vaccine Antigen, FHbp, Impair Processing Affecting Surface Localization and Antibody-Mediated Killing in Most Meningococcal Isolates Open
In the original article, there was a mistake in Table 2. The designation of Class 2 and Class isolates have been switched with each other. The corrected Table 2 is shown below. The SP class is indicated for each isolateThe authors apologiz…
View article: Variant Signal Peptides of Vaccine Antigen, FHbp, Impair Processing Affecting Surface Localization and Antibody-Mediated Killing in Most Meningococcal Isolates
Variant Signal Peptides of Vaccine Antigen, FHbp, Impair Processing Affecting Surface Localization and Antibody-Mediated Killing in Most Meningococcal Isolates Open
[This corrects the article DOI: 10.3389/fmicb.2019.02847.].
View article: Vaccine antigen, Factor H binding protein, is typically a non-lipidated precursor that localises to the meningococcal surface by Slam
Vaccine antigen, Factor H binding protein, is typically a non-lipidated precursor that localises to the meningococcal surface by Slam Open
Meningococcal surface lipoprotein, Factor H binding protein (FHbp), is the sole antigen of the Trumenba vaccine (Pfizer) and one of four antigens of the Bexsero vaccine (GSK) targeting Neisseria meningitidis serogroup B isolates. Lipidatio…
View article: Potential Use of the Maillard Reaction for Pharmaceutical Applications: Gastric and Intestinal Controlled Release Alginate-Albumin Beads
Potential Use of the Maillard Reaction for Pharmaceutical Applications: Gastric and Intestinal Controlled Release Alginate-Albumin Beads Open
In this study, bovine serum albumin (BSA) and alginate (ALG) conjugates were synthesized by the Maillard reaction in order to evaluate their potential to develop controlled release drug delivery systems. The progress of the Maillard reacti…
View article: Drug metabolism and antibiotic resistance in micro‐organisms
Drug metabolism and antibiotic resistance in micro‐organisms Open
Linked Articles This article is part of a themed section on Drug Metabolism and Antibiotic Resistance in Micro‐organisms. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.14/issuetoc
View article: Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti‐tubercular agents using a fragment‐based drug design approach
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti‐tubercular agents using a fragment‐based drug design approach Open
Background and Purpose With the emergence of extensively drug‐resistant tuberculosis, there is a need for new anti‐tubercular drugs that work through novel mechanisms of action. The meta cleavage product hydrolase, HsaD, has been demonstra…
View article: The role of apolipoprotein N‐acyl transferase, Lnt, in the lipidation of factor H binding protein of <i>Neisseria meningitidis</i> strain MC58 and its potential as a drug target
The role of apolipoprotein N‐acyl transferase, Lnt, in the lipidation of factor H binding protein of <i>Neisseria meningitidis</i> strain MC58 and its potential as a drug target Open
Background and Purpose The level of cell surface expression of the meningococcal vaccine antigen, Factor H binding protein (FHbp) varies between and within strains and this limits the breadth of strains that can be targeted by FHbp‐based v…
View article: Azoreductases in drug metabolism
Azoreductases in drug metabolism Open
Azoreductases are flavoenzymes that have been characterized in a range of prokaryotes and eukaryotes. Bacterial azoreductases are associated with the activation of two classes of drug, azo drugs for the treatment of inflammatory bowel dise…