Sher Ali
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View article: Green Cobalt nanoparticles used as a photocatalytic agent for the degradation of methylene blue dye
Green Cobalt nanoparticles used as a photocatalytic agent for the degradation of methylene blue dye Open
The nanoparticles of cobalt synthesized by adding of Pomegranate peels to cobalt nitrate salt. The cobalt nanoparticles appear rapidly with change in color. The cobalt characterized by UV Visible Absorption Spectrometer and Scanning Electr…
View article: BIOTECHNOLOGICAL APPROACHES TO BIOREMEDIATION AND WASTEWATER TREATMENT: UTILIZING MICROBIAL AND ENZYMATIC STRATEGIES TO DEGRADE POLLUTANTS AND TOXIC SUBSTANCES: A REVIEW
BIOTECHNOLOGICAL APPROACHES TO BIOREMEDIATION AND WASTEWATER TREATMENT: UTILIZING MICROBIAL AND ENZYMATIC STRATEGIES TO DEGRADE POLLUTANTS AND TOXIC SUBSTANCES: A REVIEW Open
Background: Environmental pollution from industrial, agricultural, and municipal sources presents a significant threat to ecological and human health. As traditional wastewater treatment methods face limitations in cost, efficiency, and po…
View article: Modulating ion channels with nanobodies
Modulating ion channels with nanobodies Open
Ion channels play instrumental roles in regulating membrane potential and cross-membrane signal transduction, thus making them attractive targets for understanding various physiological processes and associated diseases. Gaining a deeper u…
View article: Briefly highlighting some unseen evidence of two comorbid COVID-19 patients
Briefly highlighting some unseen evidence of two comorbid COVID-19 patients Open
In recent years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and mortality worldwide. Comorbidities have negatively impacted the pandemic of coronavirus disease 2019 (COVID-19). This case r…
View article: System biology approach to delineate expressional difference in the blood mononuclear cells between healthy and Turner syndrome individuals
System biology approach to delineate expressional difference in the blood mononuclear cells between healthy and Turner syndrome individuals Open
Background Turner syndrome (TS) is a rare disorder associated either with complete or partial loss of one X chromosome in women. The information on the genotype–phenotype relationship in TS is inadequate. Comparing the healthy and Turner s…
View article: Genome-wide CRISPR screen identifies AC9 as a key regulator of ER Ca<sup>2+</sup>homeostasis involved in neuronal differentiation
Genome-wide CRISPR screen identifies AC9 as a key regulator of ER Ca<sup>2+</sup>homeostasis involved in neuronal differentiation Open
Endoplasmic reticulum (ER) calcium (Ca 2+ ) homeostasis is essential for maintaining normal cellular physiological functions. Its disturbance is strongly linked to the onset and progression of human diseases, including cancer, developmenta…
View article: Impaired intracellular Ca <sup>2+</sup> signaling contributes to age-related cerebral small vessel disease in <i>Col4a1</i> mutant mice
Impaired intracellular Ca <sup>2+</sup> signaling contributes to age-related cerebral small vessel disease in <i>Col4a1</i> mutant mice Open
Humans and mice with mutations in COL4A1 and COL4A2 manifest hallmarks of cerebral small vessel disease (cSVD). Mice with a missense mutation in Col4a1 at amino acid 1344 ( Col4a1 +/G1344D ) exhibit age-dependent intracerebral hemorrhages …
View article: PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease
PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease Open
Neurovascular coupling (NVC), a vital physiological process that rapidly and precisely directs localized blood flow to the most active regions of the brain, is accomplished in part by the vast network of cerebral capillaries acting as a se…
View article: Salivary transforming growth factor beta in oral submucous fibrosis: A diagnostic and predictive marker
Salivary transforming growth factor beta in oral submucous fibrosis: A diagnostic and predictive marker Open
Context: Growth factors and cytokines like transforming growth factor beta (TGF-β) play a key role in the pathogenesis of oral submucous fibrosis. Aims: To elucidate the role of Salivary TGF-β isoforms as a predictive and diagnostic marker…
View article: Impact of vitamin C supplementation on composition, stability, fatty acids profile, organic acids, antioxidant properties and sensoric acceptability of cultured buttermilk
Impact of vitamin C supplementation on composition, stability, fatty acids profile, organic acids, antioxidant properties and sensoric acceptability of cultured buttermilk Open
Buttermilk is a fermented drink widely used all over the world. It is produced widely both traditionally and commercially through pasteurization. Buttermilk, produced during churning of cultured cream, was supplemented with vitamin C at fo…
View article: Delineating Expressional Difference in the Blood Mononuclear Cells between Healthy and Turner Syndrome Individuals
Delineating Expressional Difference in the Blood Mononuclear Cells between Healthy and Turner Syndrome Individuals Open
Turner Syndrome (TS) is a rare disorder associated either with complete or partial loss of one X chromosome in women. Comparing the healthy and individuals with Turner Syndrome may help elucidate the mechanisms involved in TS pathophysiolo…
View article: PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease
PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease Open
Neurovascular coupling (NVC), a vital physiological process that rapidly and precisely directs localized blood flow to the most active regions of the brain, is accomplished in part by the vast network of cerebral capillaries acting as a se…
View article: Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome
Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome Open
Gould syndrome is a rare multisystem disorder resulting from autosomal dominant mutations in the collagen-encoding genes COL4A1 and COL4A2. Human patients and Col4a1 mutant mice display brain pathology that typifies cerebral small vessel d…
View article: The effectiveness of non-Invasive ventilation in Covid-19 patients
The effectiveness of non-Invasive ventilation in Covid-19 patients Open
Background: Endotracheal intubation is avoided more often with noninvasive ventilation (NIV) in COVID-19 patients with hypoxemia. An endotracheal or tracheostomy tube is not required to use the NIV to deliver mechanical ventilation. When i…
View article: Real World Data about the Characteristics of Adult Diabetes Mellitus Patients Visiting Outpatient Department of a Tertiary Care Hospital
Real World Data about the Characteristics of Adult Diabetes Mellitus Patients Visiting Outpatient Department of a Tertiary Care Hospital Open
Objective: To find our characteristics of adult diabetes mellitus (DM) patients visiting outpatient department (OPD) of a tertiary care hospital. Study Design: Observational, cross-sectional study. Place and Duration: Outpatient department…
View article: Synthesis of 3D Cadmium(II)-Carboxylate Framework Having Potential for Co-Catalyst Free CO2 Fixation to Cyclic Carbonates
Synthesis of 3D Cadmium(II)-Carboxylate Framework Having Potential for Co-Catalyst Free CO2 Fixation to Cyclic Carbonates Open
Metal-organic frameworks (MOFs) are porous coordination polymers with interesting structural frameworks, properties, and a wide range of applications. A novel 3D cadmium(II)-carboxylate framework, CdMOF ([Cd2(L)(DMF)(H2O)2]n), was synthesi…
View article: Spatio-Temporal Analysis of Land Use Land Cover, Dynamics in Built-up Area and Its Trend Predictions in Peshawar Vale, Pakistan
Spatio-Temporal Analysis of Land Use Land Cover, Dynamics in Built-up Area and Its Trend Predictions in Peshawar Vale, Pakistan Open
This study focused on the Spatio-temporal monitoring of land use land cover, built-up area, its trend, and its prediction in the valley of Peshawar, Pakistan. The collected data from 1990 to 2020 were spatiotemporally analyzed in GIS to ge…
View article: PHYSICAL AND MECHANICAL CHARACTERIZATION OF STRUCTURAL WOOD USED IN PAKISTAN
PHYSICAL AND MECHANICAL CHARACTERIZATION OF STRUCTURAL WOOD USED IN PAKISTAN Open
Six species of wood (Vachellia nilotica,Eucalyptus camaldulensis, Ziziphus mauritiana, Albizia lebbeck, Melia azedarach, Dalbergia sissoo)weretested in compression and tension parallel to the grain. The specimens were collected from differ…
View article: Spatio-Temporal Expansion of Built-Up Areas and its Impact on Farmland and Food Security of Peshawar Valley, Pakistan
Spatio-Temporal Expansion of Built-Up Areas and its Impact on Farmland and Food Security of Peshawar Valley, Pakistan Open
valley.As the built-up area is increasing rapidly at the cost of prime agricultural land, if the land use transformation remains constant, it is impossible for the existing cultivated land to feed the increasing inhabitants of Peshawar val…
View article: Author response: STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells
Author response: STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Peripheral coupling between the…
View article: Peripheral Coupling Sites Formed by STIM1 Govern the Contractility of Vascular Smooth Muscle Cells
Peripheral Coupling Sites Formed by STIM1 Govern the Contractility of Vascular Smooth Muscle Cells Open
Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM) forms signaling complexes that regulate the membrane potential and contractility of vascular smooth muscle cells (VSMCs), although the mechanisms responsi…
View article: Meat Production and Supply Chain Under COVID-19 Scenario: Current Trends and Future Prospects
Meat Production and Supply Chain Under COVID-19 Scenario: Current Trends and Future Prospects Open
The COVID-19 pandemic impacted meat production, supply chain, and meat prices that caused a severe socio-economic crisis worldwide. Initially, meat and meat products' prices increased due to less production and increased demand because of …
View article: Circadian clock modulating small molecules repurposing as inhibitors of SARS-CoV-2 M<sup>pro</sup> for pharmacological interventions in COVID-19 pandemic
Circadian clock modulating small molecules repurposing as inhibitors of SARS-CoV-2 M<sup>pro</sup> for pharmacological interventions in COVID-19 pandemic Open
The COVID-19 pandemic caused by SARS-CoV-2 is a global health emergency warranting the development of targeted treatment. The main protease Mpro is considered as a key drug target in coronavirus infections because of its vital role in the …
View article: Brain endothelial cell TRPA1 channels initiate neurovascular coupling
Brain endothelial cell TRPA1 channels initiate neurovascular coupling Open
Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary endothelial cells are stimulated by neuronal activity and instigate…