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View article: Evaluating the long-term efficacy of umbilical cord-derived mesenchymal stem cell therapy in retinitis pigmentosa: findings from a 1-to-4-year follow-up
Evaluating the long-term efficacy of umbilical cord-derived mesenchymal stem cell therapy in retinitis pigmentosa: findings from a 1-to-4-year follow-up Open
Background The objective of this study was to assess the long-term effectiveness and safety of implanting mesenchymal stem cells derived from umbilical cord tissue (UC-MSC) in patients diagnosed with retinitis pigmentosa (RP). Methods In t…
View article: Low-dose anti-thymocyte globulin combined with low-dose post-transplant cyclophosphamide: a novel approach to prevent graft-versus-host disease in haploidentical stem cell transplantation
Low-dose anti-thymocyte globulin combined with low-dose post-transplant cyclophosphamide: a novel approach to prevent graft-versus-host disease in haploidentical stem cell transplantation Open
Background: In haploidentical hematopoietic stem cell transplantation (haplo-HSCT), combining low-dose post-transplant cyclophosphamide (PTCy) with low-dose anti-thymocyte globulin (ATG) is increasingly recognized as a promising approach f…
View article: The efficacy and safety of therapeutic thrombocytapheresis in patients with extreme thrombocytosis
The efficacy and safety of therapeutic thrombocytapheresis in patients with extreme thrombocytosis Open
Introduction Therapeutic thrombocytapheresis (TTA) is used to promptly reduce platelet count to prevent thrombohemorrhagic complications that may develop in extreme thrombocytosis. In this study, the efficacy and safety of TTA were investi…
View article: Familial hemophagocytic lymphohistiocytosis case in adult age
Familial hemophagocytic lymphohistiocytosis case in adult age Open
Hemophagocytic lymphohistiocytosis (HLH) is an immune disorder with high mortality due to uncontrolled activation of T lymphocytes and macrophages and excessive proliferation of inflammatory cytokines. A 37-year-old female patient diagonse…
View article: MANAGEMENT OF BLEEDING IN A PATIENT WITH ACQUIRED HAEMOPHILIA A: A CASE REPORT
MANAGEMENT OF BLEEDING IN A PATIENT WITH ACQUIRED HAEMOPHILIA A: A CASE REPORT Open
Objective: Acquired haemophilia A (AHA) is a blood clotting disorder caused by the presence of autoantibodies that interfere with the function of factor VIII, often called factor VIII inhibitor (1). It has a prevalence of about one per mil…
View article: Is CMV PCR Monitoring Necessary for Hematological Malignancy during Chemotherapy?
Is CMV PCR Monitoring Necessary for Hematological Malignancy during Chemotherapy? Open
Introduction: Cytomegalovirus (CMV) is an important cause of mortality and morbidity in patients with immune defects. Due to the extensive use of immunosuppressive treatments, CMV infections have emerged as one of the most critical problem…
View article: Follow-up of patients given isoniazid prophylaxis in multiple myeloma patients underwent autologous stem cell transplantation
Follow-up of patients given isoniazid prophylaxis in multiple myeloma patients underwent autologous stem cell transplantation Open
Aims: With the developments in recent years, multiple myeloma (MM) a plasma cell discrazy has become a disease whose life expectancy is expressed in 10 years. Stem cell transplantation still maintains its place in this disease and post-tra…
View article: Uric Acid Levels Might be A Prognostic Indicator For Survival in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation. Single-Center Experience
Uric Acid Levels Might be A Prognostic Indicator For Survival in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation. Single-Center Experience Open
Uric acid (UA) is an abundant aqueous antioxidant that accounts for almost two-thirds of all free- free-radical-scavenging activity in human serum. It is released from injured cells during conditioning for allogeneic hematopoietic stem cel…
View article: Determination of the therapeutic effects of apigenin on chronic myeloid leukemia stem cells; a mechanistic approach
Determination of the therapeutic effects of apigenin on chronic myeloid leukemia stem cells; a mechanistic approach Open
Aims: Chronic myeloid leukemia (CML) is a type of leukemia characterized by the Philadelphia (Ph) chromosome encoding the BCR-ABL protein. Significant success has been achieved in the treatment of CML with the development of agents that ta…
View article: FLUDARABINE-INDUCED BRADYCARDIA IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
FLUDARABINE-INDUCED BRADYCARDIA IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION Open
Objective: Fludarabine, a purine analog, is getting more attention with the increasing use of reduced intensive conditioning regimens in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Bradycardia was observed in only a few…
View article: AUTOLOGOUS STEM CELL TRANSPLANTATION EXPERIENCE IN B-ALL DEVELOPING DURING MAINTENANCE LENALIDOMIDE TREATMENT:CASE REPORT
AUTOLOGOUS STEM CELL TRANSPLANTATION EXPERIENCE IN B-ALL DEVELOPING DURING MAINTENANCE LENALIDOMIDE TREATMENT:CASE REPORT Open
Case report: Introduction: Secondary leukemias that occur after chemotherapy are mostly myelodysplastic syndrome and acute myeloid leukemias.With the recent increased use of immunomodulatory (IMID) drugs (pomalidomide, thalidomide and lena…
View article: GRANULOCYTE TRANSFUSION ACCELERATES RECOVERY FROM NEUTROPENIA IN PATIENTS WITH HEMATOLOGIC MALIGNANCIES
GRANULOCYTE TRANSFUSION ACCELERATES RECOVERY FROM NEUTROPENIA IN PATIENTS WITH HEMATOLOGIC MALIGNANCIES Open
Objective: Neutropenia is the most common and serious consequence of myelosuppressive chemotherapy in patients with hematologic malignancies.Granulocyte transfusions can restore granulocyte counts and thus theoretically reduce the risk of …
View article: Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors
Comparison of drug–drug interaction checking databases for interactions involving BCR-ABL tyrosine kinase inhibitors Open
Background and Aims: BCR-ABL tyrosine kinase inhibitors (TKIs) are used for the treatment of chronic myeloid leukemia and are commonly involved in clinically significant drug–drug interactions (DDIs). In this study, we aimed to evaluate th…
View article: Outcomes of allogeneic haematopoietic cell transplantation for myelofibrosis in children and adolescents: the retrospective study of the EBMT Paediatric Diseases WP
Outcomes of allogeneic haematopoietic cell transplantation for myelofibrosis in children and adolescents: the retrospective study of the EBMT Paediatric Diseases WP Open
This retrospective study evaluated 35 children (median age 5.2 years; range 0.4–18) with myelofibrosis (MF), including 33 with primary myelofibrosis and 2 with secondary myelofibrosis transplanted from matched sibling donor (MSD) ( n = 17)…
View article: Determination of Risk Factors for Infectious Diarrhea in Patients with Hematological Malignancy
Determination of Risk Factors for Infectious Diarrhea in Patients with Hematological Malignancy Open
Infectious diarrhea lasts longer than unidentified diarrhea in patients with hematological malignancies. Although corticosteroid use is a risk factor for developing infectious diarrhea, GCSF use has a protective effect.
View article: Germline genetic variants in Turkish familial multiple myeloma/monoclonal gammopathy of undetermined significance cases
Germline genetic variants in Turkish familial multiple myeloma/monoclonal gammopathy of undetermined significance cases Open
Summary Multiple myeloma (MM) is a haematological malignancy primarily affecting the elderly, with a striking male predilection and ethnic disparities in incidence. Familial predisposition to MM has long been recognized, but the genetic un…
View article: Allogeneic HSCT for classical BCR::ABL1-negative myeloproliferative neoplasms in children: the retrospective study of the EBMT Pediatric Diseases WP
Allogeneic HSCT for classical BCR::ABL1-negative myeloproliferative neoplasms in children: the retrospective study of the EBMT Pediatric Diseases WP Open
This retrospective EBMT registry-based study evaluated 42 children (0.4–18 years, median 6.1) with BCR::ABL1-neg MPN (PMF, n = 33; ET, n = 3; PV, n = 1, sAML, 3; post-ET/PV-MF, n = 2) transplanted from MSD (n = 21) or non-MSD (n = 21) betw…
View article: IBRUTINIB RELATED NEUROPATHY: A CASE REPORT
IBRUTINIB RELATED NEUROPATHY: A CASE REPORT Open
Case report Introduction: Chronic lymphocytic leukemia (CLL) is the most common leukemia seen in adulthood and mostly affects the older age group. The treatment of CLL has completely changed in recent years with the discovery of new agents…
View article: Second Allogeneic Stem Cell Transplantation in Acute Leukemia with Post-Transplantation Relapse
Second Allogeneic Stem Cell Transplantation in Acute Leukemia with Post-Transplantation Relapse Open
Aim: It is known that the prognosis of acute leukemia patients who relapse after the first allogeneic stem cell transplantation (ASCT) is dismal. Our goal was to assess the value of a second allogeneic stem cell transplant in acute leukemi…
View article: Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation
Drug-Drug Interaction Intensity Differences Depending On The Hematopoietic Stem Cell Transplantation Type And Existing Polypharmacy Prior To Transplantation Open
Introduction: Drug drug interactions can effect the success of stem cell transplantation process. Therefore, analyzing the risk of these interactions would be helpful for practitioners. This study was conducted to identify drug-drug intera…
View article: Cold autoimmune hemolytic anemia
Cold autoimmune hemolytic anemia Open
Cold agglutinins are antibodies that recognize antigens on erythrocytes at temperatures below normal body temperature. Antibodies are of IgM nature and bind to “I” or “i” antigens on red blood cells, causing agglutination in red blood cell…
View article: P872: EFFICACY OF DARATUMUMAB PLUS BORTEZOMIB, CYCLOPHOSPHAMIDE AND DEXAMETHASONE IN PATIENTS WITH MULTIPLE MYELOMA PRESENTING WITH EXTRAMEDULLARY DISEASE: A EUROPEAN MYELOMA NETWORK STUDY (EMN19)
P872: EFFICACY OF DARATUMUMAB PLUS BORTEZOMIB, CYCLOPHOSPHAMIDE AND DEXAMETHASONE IN PATIENTS WITH MULTIPLE MYELOMA PRESENTING WITH EXTRAMEDULLARY DISEASE: A EUROPEAN MYELOMA NETWORK STUDY (EMN19) Open
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: Multiple myeloma (MM) with extramedullary disease (EMD) is an aggressive disease requiring novel treatment approaches. Aims: To present interim results on the effi…
View article: A CASE REPORT OF AQUAPORIN-4 ANTIBODY NEGATIVE OLIGOCLONAL BAND TYPE 2 POSITIVE NEUROMYELITIS OPTICA SPECTRUM DISORDER
A CASE REPORT OF AQUAPORIN-4 ANTIBODY NEGATIVE OLIGOCLONAL BAND TYPE 2 POSITIVE NEUROMYELITIS OPTICA SPECTRUM DISORDER Open
Introduction. Neuromyelitis optica spectrum disorder is a rare anticor-mediated demyelinating disease of the central nervous system. Long segment myelitis, persistent vomiting and hiccups, or optic neuritis are classic symptoms of the dise…
View article: Clofarabine, cyclophosphamide, and etoposide (CLOVE) in adult patients with relapsed/refractory acute T-cell lymphoblastic leukemia: single-center experience
Clofarabine, cyclophosphamide, and etoposide (CLOVE) in adult patients with relapsed/refractory acute T-cell lymphoblastic leukemia: single-center experience Open
Purpose: Clofarabine is a second-generation purine analog that inhibits DNA synthesis. It is used as an effective new agent in relapsed refractory acute leukemia. We aimed to report our single center experience about CLOVE protocol as a cl…
View article: The effect of granulocyte transfusion on engraftment in patients with allogeneic hematopoietic stem cell transplantation
The effect of granulocyte transfusion on engraftment in patients with allogeneic hematopoietic stem cell transplantation Open
Aim: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is still one of the most effective treatments for many hematological malignancies. However, especially infections and neutropenic fever increase mortality during the engra…
View article: Adult Onset Langerhans Cell Histiocytosis: A Single Center Experience
Adult Onset Langerhans Cell Histiocytosis: A Single Center Experience Open
Aim: Langerhans cell histiocytosis (LCH) is a proliferative disease caused by abnormal proliferation of histiocytes in the bone marrow dendritic cell structure. LCH is very rare in adults and its incidence is 1-2 cases per million. Therefo…