Ália dos Santos
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View article: Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells
Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells Open
Approximately 75% of breast cancer cases are estrogen receptor (ER)-positive, with endocrine therapies forming the foundation of treatment. However, therapeutic resistance remains a major clinical challenge, necessitating the identificatio…
View article: <i>In-cell</i> structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells
<i>In-cell</i> structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells Open
In eukaryotic cells, LINC complexes physically bridge the two nuclear membranes to cytoskeletal filaments, transmitting mechanical forces to the nucleus. Due to their dynamic and membrane-embedded nature, their architecture in native membr…
View article: Paclitaxel compromises nuclear integrity in interphase through SUN2-mediated cytoskeletal coupling
Paclitaxel compromises nuclear integrity in interphase through SUN2-mediated cytoskeletal coupling Open
Regulation of Lamin A/C levels and distribution is crucial for nuclear integrity and mechanotransduction via the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex. Dysregulation of Lamin A/C correlates with poor cancer prognosis, an…
View article: Human spermatogenesis leads to a reduced nuclear pore structure and function
Human spermatogenesis leads to a reduced nuclear pore structure and function Open
Nuclear pore complexes (NPCs) are nuclear gateways which regulate the transit of molecules larger than 40kDa through a Ran-dependent transport 1 . The somatic human NPC scaffold consists of three stacked rings: the cytoplasmic (CR), the nu…
View article: Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription
Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription Open
NDP52 is an autophagy receptor involved in the recognition and degradation of invading pathogens and damaged organelles. Although NDP52 was first identified in the nucleus and is expressed throughout the cell, to date, there is no clear nu…
View article: Binding partners regulate unfolding of myosin VI to activate the molecular motor
Binding partners regulate unfolding of myosin VI to activate the molecular motor Open
Myosin VI is the only minus-end actin motor and it is coupled to various cellular processes ranging from endocytosis to transcription. This multi-potent nature is achieved through alternative isoform splicing and interactions with a networ…
View article: Myosin VI regulates the spatial organisation of mammalian transcription initiation
Myosin VI regulates the spatial organisation of mammalian transcription initiation Open
During transcription, RNA Polymerase II (RNAPII) is spatially organised within the nucleus into clusters that correlate with transcription activity. While this is a hallmark of genome regulation in mammalian cells, the mechanisms concernin…
View article: Autophagy receptor NDP52 alters DNA conformation to modulate RNA Polymerase II transcription
Autophagy receptor NDP52 alters DNA conformation to modulate RNA Polymerase II transcription Open
NDP52 is an autophagy receptor involved in the recognition and degradation of invading pathogens and damaged organelles. Although NDP52 was first identified in the nucleus and is expressed throughout the cell, to date, there is no clear nu…
View article: Regulation of Nuclear Mechanics and the Impact on DNA Damage
Regulation of Nuclear Mechanics and the Impact on DNA Damage Open
In eukaryotic cells, the nucleus houses the genomic material of the cell. The physical properties of the nucleus and its ability to sense external mechanical cues are tightly linked to the regulation of cellular events, such as gene expres…
View article: A Targeted and Tuneable DNA Damage Tool Using CRISPR/Cas9
A Targeted and Tuneable DNA Damage Tool Using CRISPR/Cas9 Open
Mammalian cells are constantly subjected to a variety of DNA damaging events that lead to the activation of DNA repair pathways. Understanding the molecular mechanisms of the DNA damage response allows the development of therapeutics which…
View article: A targeted and tuneable DNA damage tool using CRISPR/Cas9
A targeted and tuneable DNA damage tool using CRISPR/Cas9 Open
Mammalian cells are constantly subjected to a variety of DNA damaging events that lead to the activation of DNA repair pathways. Understanding the molecular mechanisms of the DNA damage response allows the development of therapeutics which…
View article: High-throughput mechanobiology: Force modulation of ensemble biochemical and cell-based assays
High-throughput mechanobiology: Force modulation of ensemble biochemical and cell-based assays Open
View article: DNA damage alters nuclear mechanics through chromatin reorganization
DNA damage alters nuclear mechanics through chromatin reorganization Open
DNA double-strand breaks drive genomic instability. However, it remains unknown how these processes may affect the biomechanical properties of the nucleus and what role nuclear mechanics play in DNA damage and repair efficiency. Here, we h…
View article: DNA damage alters nuclear mechanics through chromatin reorganisation
DNA damage alters nuclear mechanics through chromatin reorganisation Open
DNA double-strand breaks (DSBs) drive genomic instability. For efficient and accurate repair of these DNA lesions, the cell activates DNA damage repair pathways. However, it remains unknown how these processes may affect the biomechanical …
View article: Binding partners regulate unfolding of myosin VI to activate the molecular motor
Binding partners regulate unfolding of myosin VI to activate the molecular motor Open
Myosin VI is the only minus-end actin motor and is coupled to various cellular processes ranging from endocytosis to transcription. This multi-potent nature is achieved through alternative isoform splicing and interactions with a network o…
View article: High throughput mechanobiology: Force modulation of ensemble biochemical and cell-based assays
High throughput mechanobiology: Force modulation of ensemble biochemical and cell-based assays Open
Mechanobiology is focused on how the physical forces and the mechanical properties of proteins, cells and tissues contribute to physiology and disease. While the response of proteins and cells to mechanical stimuli is critical for function…
View article: Nuclear myosin VI regulates the spatial organization of mammalian transcription initiation
Nuclear myosin VI regulates the spatial organization of mammalian transcription initiation Open
SUMMARY During transcription, RNA Polymerase II (RNAPII) is spatially organised within the nucleus into clusters that correlate with transcription activity. While this is a hallmark of genome regulation in mammalian cells, the mechanisms c…
View article: Competition between two high- and low-affinity protein-binding sites in myosin VI controls its cellular function
Competition between two high- and low-affinity protein-binding sites in myosin VI controls its cellular function Open
View article: Binding partner regulation of Myosin VI: Loss of tumour-suppressor Dab2 leads to enhanced activity of nuclear myosin
Binding partner regulation of Myosin VI: Loss of tumour-suppressor Dab2 leads to enhanced activity of nuclear myosin Open
Myosin VI is involved in a variety of cellular processes ranging from endocytosis to transcription. This multi-functional potential is achieved through alternative isoform splicing and through the interaction with a diverse network of bind…
View article: Nuclear Myosin VI Stabilizes RNA Polymerase II in Transcription Factories
Nuclear Myosin VI Stabilizes RNA Polymerase II in Transcription Factories Open
View article: Nuclear Myosin VI Regulates Estrogen Receptor Driven Gene Expression
Nuclear Myosin VI Regulates Estrogen Receptor Driven Gene Expression Open
View article: NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription
NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription Open
View article: Atomic Force Microscopy micro-rheology reveals large structural inhomogeneities in single cell-nuclei
Atomic Force Microscopy micro-rheology reveals large structural inhomogeneities in single cell-nuclei Open
View article: Comparative stability of Major Facilitator Superfamily transport proteins
Comparative stability of Major Facilitator Superfamily transport proteins Open
View article: Oligomerization domains in the glycan‐binding receptors DC‐SIGN and DC‐SIGNR: Sequence variation and stability differences
Oligomerization domains in the glycan‐binding receptors DC‐SIGN and DC‐SIGNR: Sequence variation and stability differences Open
Human dendritic cell‐specific intercellular adhesion molecule‐1 grabbing nonintegrin, DC‐SIGN, and the sinusoidal endothelial cell receptor DC‐SIGNR or L‐SIGN, are closely related sugar‐binding receptors. DC‐SIGN acts both as a pathogen‐bi…