Explanipedia

Perioperative hemodynamic optimization - Paediatrics Open

Jean-Luc Fellahi, Matthieu Biais, Osama Abou‐Arab, Marc Beaussier, Bernard Cholley , et al. · 2025

Nine guidelines, with a high degree of agreement between experts, on perioperative hemodynamic optimization have been formulated.

Perioperative hemodynamic optimization - Adults including obstetrics Open

Jean-Luc Fellahi, Matthieu Biais, Osama Abou‐Arab, Marc Beaussier, Bernard Cholley , et al. · 2025

24 guidelines on perioperative haemodynamic optimization have been formulated, with a high degree of agreement between experts.

Consensus on the Management of Anesthetic Agents During Digestive Motility Measurements and Proposal of a Standardized Protocol for Anesthesia (French Neuro Gastroenterology Group <span>GFNG</span> and Committee of Anesthetic French Experts) Open

Dimitri Renard, Thomas Clavier, Osama Abou‐Arab, G. Amarenco, Emmanuel Besnier , et al. · 2025

Introduction Techniques for measuring digestive motility are becoming increasingly precise and enable therapeutic interventions. However, while most of these interventions require general anesthesia, there is limited data on the impact of …

Individual mHLA-DR trajectories in the ICU as predictors of early infections following liver transplantation: a prospective observational study Open

Marie‐Charlotte Delignette, Arnaud Riff, Térésa Antonini, Tanguy Soustre, Maxime Bodinier , et al. · 2025

Our findings highlight mHLA-DR as an early predictor of post-LT infections. Monitoring post-LT immune function through mHLA-DR expression could guide individualized management strategies to improve outcomes. Trial registration The study wa…

Individual mHLA-DR trajectories in the ICU as predictors of early infections following liver transplantation: a prospective observational study Open

Marie‐Charlotte Delignette, Arnaud Riff, Térésa Antonini, Tanguy Soustre, Maxime Bodinier , et al. · 2024

Background Infections are a leading cause of early mortality after liver transplantation (LT). Prior to transplantation, cirrhosis-associated immune dysfunction significantly increases the risk of infection. This study investigated the pot…

Current and future trial design in refractory cardiogenic shock Open

Mattia Arrigo, Alice Blet, Andrew Morley‐Smith, Nadia Aïssaoui, David A. Baran , et al. · 2023

International audience

Insulin-like growth factor-binding protein-7 (IGFBP7) links senescence to heart failure Open

Liyong Zhang, David Smyth, Mohammad Al‐Khalaf, Alice Blet, Qiujiang Du , et al. · 2022

Heart failure (HF) is a rising global cardiovascular epidemic driven by aging and chronic inflammation. As elderly populations continue to increase, precision treatments for age-related cardiac decline are urgently needed. Here we report t…

Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors Open

Alice Blet, J. Brennan McNeil, Julie Josse, Bernard Cholley, Raphaël Cinotti , et al. · 2022

Features of Inflammatory Heart Reactions Following mRNA COVID‐19 Vaccination at a Global Level Open

Laurent Chouchana, Alice Blet, Mohammad Al‐Khalaf, Tahir S Kafil, Girish M. Nair , et al. · 2021

Myocarditis and pericarditis may constitute adverse reactions of mRNA coronavirus disease 2019 (COVID‐19) vaccines. This study aimed to document these reactions and to assess the association with patient sex and age. This is as an observat…

Elevated Plasma Bioactive Adrenomedullin and Mortality in Cardiogenic Shock: Results from the OptimaCC Trial Open

Koji Takagi, Bruno Lévy, Antoine Kimmoun, Òscar Miró, Kévin Duarte , et al. · 2021

Aims: Bioactive adrenomedullin (bio-ADM) was recently shown to be a prognostic marker in patients with acute circulatory failure. We investigate the association of bio-ADM with organ injury, functional impairment, and survival in cardiogen…

Cardiac Inflammation after COVID-19 mRNA Vaccines: A Global Pharmacovigilance Analysis Open

Laurent Chouchana, Alice Blet, Mohammad Al‐Khalaf, Tahir S Kafil, Girish M. Nair , et al. · 2021

Background To counter the COVID-19 pandemic, mRNA vaccines, namely tozinameran and elasomeran, have been authorized in several countries. These next generation vaccines have shown high efficacy against COVID-19 and demonstrated a favorable…

Activity of the adrenomedullin system to personalise post-discharge diuretic treatment in acute heart failure Open

Nikola Kozhuharov, Leong L. Ng, Desirée Wussler, Ivo Strebel, Zaid Sabti , et al. · 2021

Efficacité vaccinale sur les hospitalisations liées au COVID-19 et les variants Open

Sacha Rozencwajg, Alice Blet, Antoine Lamer, Thomas Clavier, Osama Abou‐Arab , et al. · 2021

The Physiological Deep Learner: First application of multitask deep learning to predict hypotension in critically ill patients Open

Ményssa Cherifa, Yannet Interian, Alice Blet, Matthieu Resche‐Rigon, Romain Pirracchio · 2021

The <span>CLIP</span>‐based mortality score in cardiogenic shock: suitable only for cardiogenic shock? Open

Benjamin Deniau, Adrien Picod, Fériel Azibani, Étienne Gayat, Alexandre Mebazaa , et al. · 2021

International audience

SARS-CoV-2 vaccination efficacy on hospitalisation and variants Open

Sacha Rozencwajg, Alice Blet, Antoine Lamer, Thomas Clavier, Osama Abou‐Arab , et al. · 2021

Quel impact de la présence sur les réseaux sociaux pour un journal médical ? L’exemple de l’équipe dédiée d’Anaesthesia Critical Care and Pain Medicine Open

Thomas Clavier, Stéphanie Sigaut, Fanny Vardon‐Bounes, Arthur James, Denis Frasca , et al. · 2021

SARS-CoV-2 vaccination efficacy on hospitalisation and variants Open

Sacha Rozencwajg, Alice Blet, Antoine Lamer, Matthieu Boisson, Thomas Clavier , et al. · 2021

Link between postoperative ileus and anastomotic leakage: A structural equation modelling approach Open

Aurélien Venara, Jean‐François Hamel, Laura Beyer‐Berjot, Timothée Vignaud, K. Slim , et al. · 2021

Postoperative ileus(POI) and anastomotic leakage(AL) are highly associated but the direction of this link is unknown. Indeed, it has traditionally been stated that AL leads to POI(secondary POI). The objective was to statistically determin…

Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study Open

Alice Blet, Benjamin Deniau, Karine Santos, Dirk van Lier, Fériel Azibani , et al. · 2021

Positive effects of lumbar puncture simulation training for medical students in clinical practice Open

Sinead Gaubert, Alice Blet, Fadia Dib, Pierre‐François Ceccaldi, Thomas Brock , et al. · 2021

Inhibition of circulating dipeptidyl-peptidase 3 restores cardiac function in a sepsis-induced model in rats: A proof of concept study Open

Benjamin Deniau, Alice Blet, Karine Santos, Prabakar Vaittinada Ayar, Magali Genest , et al. · 2020

Sepsis is a global economic and health burden. Dipeptidyl peptidase 3 (DPP3) is elevated in the plasma of septic patients. The highest levels of circulating DPP3 (cDPP3) are found in non-survivor septic shock patients. The aim of this stud…

Redefining Cardiac Biomarkers in Predicting Mortality of Inpatients With COVID-19 Open

Juan‐Juan Qin, Xu Cheng, Feng Zhou, Fang Lei, Gauri Akolkar , et al. · 2020

The prognostic power of circulating cardiac biomarkers, their utility, and pattern of release in coronavirus disease 2019 (COVID-19) patients have not been clearly defined. In this multicentered retrospective study, we enrolled 3219 patien…

Analysis of blood culture in a rat model of cecal ligation and puncture induced sepsis Open

Prabakar Vaittinada Ayar, Hervé Jacquier, Benjamin Deniau, Fériel Azibani, Alexandre Mebazaa , et al. · 2020

International audience

Guidelines: Anaesthesia in the context of COVID-19 pandemic Open

Lionel Velly, Étienne Gayat, Hervé Quintard, Emmanuel Weiss, Audrey De Jong , et al. · 2020

Management of severe thermal burns in the acute phase in adults and children Open

Matthieu Legrand, Damien Barraud, Isabelle Constant, Pauline Devauchelle, Nicolas Donat , et al. · 2020

Substantial agreement was reached among a large cohort of experts regarding numerous strong recommendations to optimise the management of acute burn injuries in adults and children.

Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU Open

Alice Blet, Charles de Roquetaillade, Oliver Hartmann, Joachim Struck, Alexandre Mebazaa , et al. · 2020

A novel urinary biomarker predicts 1-year mortality after discharge from intensive care Open

Esther Nkuipou‐Kenfack, Agnieszka Latosińska, Wen‐Yi Yang, Marie-Céline Fournier, Alice Blet , et al. · 2020

Bioactive Adrenomedullin, Organ Support Therapies, and Survival in the Critically Ill: Results from the French and European Outcome Registry in ICU Study Open

Léa Lemasle, Alice Blet, Christopher Geven, Ményssa Cherifa, Benjamin Deniau , et al. · 2019

Objectives: Adrenomedullin has vascular properties and elevated plasma adrenomedullin levels were detected in sepsis. We assessed, in septic and nonseptic ICU patients, the relation between circulating adrenomedullin, the need for organ su…

Circulating dipeptidyl peptidase 3 and alteration in haemodynamics in cardiogenic shock: results from the OptimaCC trial Open

Koji Takagi, Alice Blet, Bruno Lévy, Benjamin Deniau, Fériel Azibani , et al. · 2019

Aims Dipeptidyl peptidase 3 (DPP3) is a protease involved in the degradation of cardiovascular mediators. Its administration has been shown to be associated with impaired cardiac contraction and kidney haemodynamics while its inhibition re…

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