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View article: Revolutionizing bone regeneration and wound healing: Mechanical stromal vascular fraction and hyaluronic acid in a mouse calvarial defect model
Revolutionizing bone regeneration and wound healing: Mechanical stromal vascular fraction and hyaluronic acid in a mouse calvarial defect model Open
Introduction The stromal vascular fraction (SVF) is a complex and heterogeneous suspension derived from adipose tissue, containing both cellular and noncellular components. Its cellular fraction includes adipose-derived stem cells (ASCs), …
View article: Gluteal femoral subcutaneous and dermal adipose tissue in female
Gluteal femoral subcutaneous and dermal adipose tissue in female Open
Background During the sexual maturation, gluteal femoral adipose tissue is subjected to numerous modifications, not observable in other regions, in particular in women and less in men. Other authors described this region, but they used ima…
View article: In Vitro Study of a Novel Vibrio alginolyticus-Based Collagenase for Future Medical Application
In Vitro Study of a Novel Vibrio alginolyticus-Based Collagenase for Future Medical Application Open
Mesenchymal stem cells extracted from adipose tissue are particularly promising given the ease of harvest by standard liposuction and reduced donor site morbidity. This study proposes a novel enzymatic method for isolating stem cells using…
View article: Highly Pluripotent Adipose-Derived Stem Cell–Enriched Nanofat: A Novel Translational System in Stem Cell Therapy
Highly Pluripotent Adipose-Derived Stem Cell–Enriched Nanofat: A Novel Translational System in Stem Cell Therapy Open
Fat graft is widely used in plastic and reconstructive surgery. The size of the injectable product, the unpredictable fat resorption rates, and subsequent adverse effects make it tricky to inject untreated fat into the dermal layer. Mechan…
View article: Doped Ferrite Nanoparticles Exhibiting Self-Regulating Temperature as Magnetic Fluid Hyperthermia Antitumoral Agents, with Diagnostic Capability in Magnetic Resonance Imaging and Magnetic Particle Imaging
Doped Ferrite Nanoparticles Exhibiting Self-Regulating Temperature as Magnetic Fluid Hyperthermia Antitumoral Agents, with Diagnostic Capability in Magnetic Resonance Imaging and Magnetic Particle Imaging Open
This paper reports a comprehensive investigation of a magnetic nanoparticle (MNP), named M55, which belongs to a class of innovative doped ferrite nanomaterials, characterized by a self-limiting temperature. M55 is obtained from M48, an MN…
View article: Correction: De Francesco et al. In Vitro Characterization of Canine Microfragmented Adipose Tissue Non-Enzymatically Extracted from the Thigh and Lumbar Regions. Animals 2021, 11, 3231
Correction: De Francesco et al. In Vitro Characterization of Canine Microfragmented Adipose Tissue Non-Enzymatically Extracted from the Thigh and Lumbar Regions. Animals 2021, 11, 3231 Open
Reetuparna Biswas was not included as an author in the original publication [...]
View article: Tissue-Material Integration and Biostimulation Study of Collagen Acellular Matrices
Tissue-Material Integration and Biostimulation Study of Collagen Acellular Matrices Open
Background: Breast reconstruction after mastectomy using silicone implants is a surgical procedure that occasionally leads to capsular contracture formation. This phenomenon constitutes an important and persistent cause of morbidity, and n…
View article: Biocompatible, photo-responsive layer-by-layer polymer nanocapsules with an oil core: <i>in vitro</i> and <i>in vivo</i> study
Biocompatible, photo-responsive layer-by-layer polymer nanocapsules with an oil core: <i>in vitro</i> and <i>in vivo</i> study Open
In cancer therapy, stimulus-responsive drug delivery systems are of particular interest for reducing side effects in healthy tissues and improving drug selectivity in the tumoral ones. Here, a strategy for the preparation of a photo-respon…
View article: In Vitro Characterization of Canine Microfragmented Adipose Tissue Non-Enzymatically Extracted from the Thigh and Lumbar Regions
In Vitro Characterization of Canine Microfragmented Adipose Tissue Non-Enzymatically Extracted from the Thigh and Lumbar Regions Open
Within the adult canine population, disabilities and symptoms including joint pain and functional impairment are commonly observed in articular cartilage lesions and present a challenging feat in the operating room. Clinical settings requi…
View article: Stem Cells in Autologous Microfragmented Adipose Tissue: Current Perspectives in Osteoarthritis Disease
Stem Cells in Autologous Microfragmented Adipose Tissue: Current Perspectives in Osteoarthritis Disease Open
Osteoarthritis (OA) is a chronic debilitating disorder causing pain and gradual degeneration of weight-bearing joints with detrimental effects on cartilage volume as well as cartilage damage, generating inflammation in the joint structure.…
View article: Contribution of preclinical MRI to responsible animal research: living up to the 3R principle
Contribution of preclinical MRI to responsible animal research: living up to the 3R principle Open
View article: Polymer-coated silver-iron nanoparticles as efficient and biodegradable MRI contrast agents
Polymer-coated silver-iron nanoparticles as efficient and biodegradable MRI contrast agents Open
View article: Nanoparticles exhibiting self-regulating temperature as innovative agents for Magnetic Fluid Hyperthermia
Nanoparticles exhibiting self-regulating temperature as innovative agents for Magnetic Fluid Hyperthermia Open
During the last few years, for therapeutic purposes in oncology, considerable attention has been focused on a method called magnetic fluid hyperthermia (MFH) based on local heating of tumor cells. In this paper, an innovative, promising na…
View article: Simple and Rapid Non-Enzymatic Procedure Allows the Isolation of Structurally Preserved Connective Tissue Micro-Fragments Enriched with SVF
Simple and Rapid Non-Enzymatic Procedure Allows the Isolation of Structurally Preserved Connective Tissue Micro-Fragments Enriched with SVF Open
The stromal vascular fraction (SVF) consists of a heterogeneous population of stem and stromal cells, generally obtained from adipose tissue by enzymatic digestion. For human cell-based therapies, mechanical process methods to obtain SVF r…
View article: 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles
4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles Open
Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of na…
View article: Artificial dermal substitutes for tissue regeneration: comparison of the clinical outcomes and histological findings of two templates
Artificial dermal substitutes for tissue regeneration: comparison of the clinical outcomes and histological findings of two templates Open
Objective Artificial dermal substitutes (DSs) are fundamental in physiological wound healing to ensure consistent and enduring wound closure and provide a suitable scaffold to repair tissue. We compared the clinical and histological featur…
View article: ASC-Exosomes Ameliorate the Disease Progression in SOD1(G93A) Murine Model Underlining Their Potential Therapeutic Use in Human ALS
ASC-Exosomes Ameliorate the Disease Progression in SOD1(G93A) Murine Model Underlining Their Potential Therapeutic Use in Human ALS Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motoneurons. To date, there is no effective treatment available. Exosomes are extracellular vesicles that play important …
View article: In Vitro Characterization of Adipose Stem Cells Non-Enzymatically Extracted from the Thigh and Abdomen
In Vitro Characterization of Adipose Stem Cells Non-Enzymatically Extracted from the Thigh and Abdomen Open
Autologous fat grafting is a surgical technique in which adipose tissue is transferred from one area of the body to another, in order to reconstruct or regenerate damaged or injured tissues. Before reinjection, adipose tissue needs to be p…
View article: Proteomic and Ultrastructural Analysis of Cellulite—New Findings on an Old Topic
Proteomic and Ultrastructural Analysis of Cellulite—New Findings on an Old Topic Open
Background: Cellulite is a condition in which the skin has a dimpled lumpy appearance. The main causes of cellulite development, studied until now, comprehends modified sensitivity to estrogens, the damage of microvasculature present among…
View article: Heterogeneous Enhancement Pattern in DCE-MRI Reveals the Morphology of Normal Lymph Nodes: An Experimental Study
Heterogeneous Enhancement Pattern in DCE-MRI Reveals the Morphology of Normal Lymph Nodes: An Experimental Study Open
Purpose . To investigate the heterogeneous enhancement pattern in normal lymph nodes of healthy mice by different albumin-binding contrast agents. Methods . The enhancement of normal lymph nodes was assessed in mice by dynamic contrast-enh…
View article: Issue Information
Issue Information Open
View article: MRI reveals therapeutical efficacy of stem cells: An experimental study on the SOD1(G93A) animal model
MRI reveals therapeutical efficacy of stem cells: An experimental study on the SOD1(G93A) animal model Open
Purpose The first part of the experiment identifies and validates MRI biomarkers distinctive of the disease progression in the transgenic superoxide dismutase gene (SOD1(G93A)) animal model. The second part assesses the efficacy of a mesen…
View article: In vivo imaging techniques: a new era for histochemical analysis
In vivo imaging techniques: a new era for histochemical analysis Open
In vivo imaging techniques can be integrated with classical histochemistry to create an actual histochemistry of water. In particular, Magnetic Resonance Imaging (MRI), an imaging technique primarily used as diagnostic tool in clinical/pre…
View article: Magnetic resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem cells: a new method to obtain labeled exosomes
Magnetic resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem cells: a new method to obtain labeled exosomes Open
We report a new approach for labeling of exosomes by USPIO that allows detection by MRI while preserving their morphology and physiological characteristics.
View article: Characterization of magnetic nanoparticles from <i>Magnetospirillum Gryphiswaldense</i> as potential theranostics tools
Characterization of magnetic nanoparticles from <i>Magnetospirillum Gryphiswaldense</i> as potential theranostics tools Open
We investigated the theranostic properties of magnetosomes (MNs) extracted from magnetotactic bacteria, promising for nanomedicine applications. Besides a physico‐chemical characterization, their potentiality as mediators for magnetic flui…