Alice J. Stelfox
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View article: Molecular basis for occlusion of the jeilongvirus receptor-binding site by the elongated C-terminus
Molecular basis for occlusion of the jeilongvirus receptor-binding site by the elongated C-terminus Open
Paramyxoviral transmission between hosts may be, in part, attributed to the ability of the viral envelope-displayed receptor-binding protein (RBP) to bind to cell surface receptors of different host species. We sought to elucidate the arch…
View article: Influenza a virus antiparallel helical nucleocapsid-like pseudo-atomic structure
Influenza a virus antiparallel helical nucleocapsid-like pseudo-atomic structure Open
Influenza A viruses are responsible for human seasonal epidemics and severe animal pandemics with a risk of zoonotic transmission to humans. The viral segmented RNA genome is encapsidated by nucleoproteins (NP) and attached to the heterotr…
View article: Crystal structure and solution state of the C-terminal head region of the narmovirus receptor binding protein
Crystal structure and solution state of the C-terminal head region of the narmovirus receptor binding protein Open
Increased viral surveillance has led to the isolation and identification of numerous uncharacterized paramyxoviruses, rapidly expanding our understanding of paramyxoviral diversity beyond the bounds of known genera. Despite this diversity,…
View article: Crystal structure and solution state of the C-terminal head region of the narmovirus receptor binding protein
Crystal structure and solution state of the C-terminal head region of the narmovirus receptor binding protein Open
Increased viral surveillance has led to the isolation and identification of numerous uncharacterized paramyxoviruses, rapidly expanding our understanding of paramyxoviral diversity beyond the bounds of known genera. Despite this diversity,…
View article: Structural basis for distinctive receptor tropism of emerging paramyxoviruses
Structural basis for distinctive receptor tropism of emerging paramyxoviruses Open
A diverse array of viruses capable of infecting both humans and animals constitute the family Paramyxoviridae (Amarasinghe et al. 2019; Fields, Knipe, and Howley 2013). Concerns regarding the interspecies transmission potential pa…
View article: Unraveling virus relationships by structure-based phylogenetic classification
Unraveling virus relationships by structure-based phylogenetic classification Open
Delineation of the intricacies of protein function from macromolecular structure constitutes a continual obstacle in the study of cell and pathogen biology. Structure-based phylogenetic analysis has emerged as a powerful tool for addressin…
View article: A structure-based rationale for sialic acid independent host-cell entry of Sosuga virus
A structure-based rationale for sialic acid independent host-cell entry of Sosuga virus Open
The bat-borne paramyxovirus, Sosuga virus (SosV), is one of many paramyxoviruses recently identified and classified within the newly established genus Pararubulavirus , family Paramyxoviridae . The envelope surface of SosV presents a recep…
View article: Cross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats
Cross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats Open
To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuVJL5), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the background of a recombinant JL5 genome (r…