Alice Koenig
YOU?
Author Swipe
View article: BK Virus: Beyond Nephropathy Metastatic BK Virus-Induced, Donor-Derived Bellini’s Carcinoma in a Kidney Allograft Recipient: Boosting Rejection to Treat the Cancer
BK Virus: Beyond Nephropathy Metastatic BK Virus-Induced, Donor-Derived Bellini’s Carcinoma in a Kidney Allograft Recipient: Boosting Rejection to Treat the Cancer Open
View article: Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejection
Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejection Open
Graft endothelial cells (ECs) express donor alloantigens and encounter cytotoxic T lymphocytes (CTLs) but are generally spared during T cell-mediated rejection (TCMR), which predominantly affects epithelial structures. The mechanisms under…
View article: <i>FCGR3A</i>F158V Genotype Accelerates Progression to Chronic Alloimmune Injury in Antibody-Mediated Kidney Transplant Rejection: A Population-Based Cohort Study
<i>FCGR3A</i>F158V Genotype Accelerates Progression to Chronic Alloimmune Injury in Antibody-Mediated Kidney Transplant Rejection: A Population-Based Cohort Study Open
Background Evidence for involvement of NK cells and monocytes as prime agents in the process of human kidney transplant rejection is expanding quickly. These cells express FCGR3A, used for antibody-dependent cellular cytotoxicity (ADCC) af…
View article: Clinical evidence for independent regulation of vitamin D by intestinal CYP24A1
Clinical evidence for independent regulation of vitamin D by intestinal CYP24A1 Open
International audience
View article: Reversible Glomerular Thrombotic Microangiopathy Associated With Nintedanib in a Kidney Transplant Recipient
Reversible Glomerular Thrombotic Microangiopathy Associated With Nintedanib in a Kidney Transplant Recipient Open
View article: γδ T Cells’ Role in Donor-Specific Antibody Generation: Insights From Transplant Recipients and Experimental Models
γδ T Cells’ Role in Donor-Specific Antibody Generation: Insights From Transplant Recipients and Experimental Models Open
The generation of donor-specific antibodies (DSA) requires that alloreactive B cells receive help from follicular helper T (T FH ) cells. Recent works have suggested that γδ T cells could contribute to T cell-dependent humoral responses, l…
View article: NK Cells: Not Just Followers But Also Initiators of Chronic Vascular Rejection
NK Cells: Not Just Followers But Also Initiators of Chronic Vascular Rejection Open
Chronic graft rejection represents a significant threat to long-term graft survival. Early diagnosis, understanding of the immunological mechanisms and appropriate therapeutic management are essential to improve graft survival and quality …
View article: FcγR3A polymorphism influences natural killer cell activation and response to anti-PD-L1 (avelumab) in gestational trophoblastic neoplasia
FcγR3A polymorphism influences natural killer cell activation and response to anti-PD-L1 (avelumab) in gestational trophoblastic neoplasia Open
Our work demonstrates that antibody-dependent cell-mediated cytotoxicity contributes to the therapeutic effect of avelumab in gestational trophoblastic neoplasia and that the individual patient response is impacted by the FcγR3A polymorphi…
View article: Longitudinal monitoring of Torque Teno virus DNAemia in kidney transplant recipients correlates with long‐term complications of inadequate immunosuppression
Longitudinal monitoring of Torque Teno virus DNAemia in kidney transplant recipients correlates with long‐term complications of inadequate immunosuppression Open
Optimization of individual immunosuppression, which reduces the risks of both graft loss and patients' death, is considered the best approach to improve long‐term outcomes of renal transplantation. Torque Teno Virus (TTV) DNAemia has emerg…
View article: Imlifidase for Kidney Transplantation of Highly Sensitized Patients With a Positive Crossmatch: The French Consensus Guidelines
Imlifidase for Kidney Transplantation of Highly Sensitized Patients With a Positive Crossmatch: The French Consensus Guidelines Open
Imlifidase recently received early access authorization for highly sensitized adult kidney transplant candidates with a positive crossmatch against an ABO-compatible deceased donor. These French consensus guidelines have been generated by …
View article: Inverted direct allorecognition triggers early donor-specific antibody responses after transplantation
Inverted direct allorecognition triggers early donor-specific antibody responses after transplantation Open
The generation of antibodies against donor-specific major histocompatibility complex (MHC) antigens, a type of donor-specific antibodies (DSAs), after transplantation requires that recipient’s allospecific B cells receive help from T cells…
View article: Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients
Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients Open
Transplant recipients, who receive therapeutic immunosuppression to prevent graft rejection, are characterized by high coronavirus disease 2019 (COVID-19)–related mortality and defective response to vaccines. We observed that previous infe…
View article: Allorecognition and the spectrum of kidney transplant rejection
Allorecognition and the spectrum of kidney transplant rejection Open
Detection of mismatched human leukocyte antigens by adaptive immune cells is considered as the main cause of transplant rejection, leading to either T-cell mediated rejection or antibody-mediated rejection. This canonical view guided the s…
View article: Cohort study: “Outcomes of kidney transplantation in patients with prosthetic heart valves”
Cohort study: “Outcomes of kidney transplantation in patients with prosthetic heart valves” Open
The number of kidney transplant candidates with prosthetic heart valves (PHVs) is increasing. Yet, outcomes of kidney transplantation in these patients are still unclear. This is the first report of post-transplant outcomes in patients wit…
View article: Comparison of infected and vaccinated transplant recipients highlights the role of Tfh and neutralizing IgG in COVID-19 protection
Comparison of infected and vaccinated transplant recipients highlights the role of Tfh and neutralizing IgG in COVID-19 protection Open
Transplant recipients, which receive therapeutic immunosuppression to prevent graft rejection, are characterized by high COVID-19-related mortality and defective response to vaccines. Having observed that previous infection by SARS-CoV-2 b…
View article: Missing Self–Induced Microvascular Rejection of Kidney Allografts: A Population-Based Study
Missing Self–Induced Microvascular Rejection of Kidney Allografts: A Population-Based Study Open
Significance Statement Microvascular inflammation (MVI) of the kidney transplant is an important determinant of allograft outcome. Although MVI is considered a cardinal manifestation of antibody-mediated rejection, it is often encountered …
View article: Improved cell signaling analysis by biofunctionalized nanospheres and imaging flow cytometry
Improved cell signaling analysis by biofunctionalized nanospheres and imaging flow cytometry Open
The analysis of immune cell signaling is critical for the understanding of the biology and pathology of the immune system, and thus a mandatory step for the development of efficient biomarkers and targeted therapies. Phosflow, which has pr…
View article: Missing Self-Induced Activation of NK Cells Combines with Non-Complement-Fixing Donor-Specific Antibodies to Accelerate Kidney Transplant Loss in Chronic Antibody-Mediated Rejection
Missing Self-Induced Activation of NK Cells Combines with Non-Complement-Fixing Donor-Specific Antibodies to Accelerate Kidney Transplant Loss in Chronic Antibody-Mediated Rejection Open
Background Binding of donor-specific antibodies (DSAs) to kidney allograft endothelial cells that does not activate the classic complement cascade can trigger the recruitment of innate immune effectors, including NK cells. Activated NK cel…
View article: Un nouveau type de rejet de greffe induit par les lymphocytes natural killer : le rejet chronique vasculaire « inné »
Un nouveau type de rejet de greffe induit par les lymphocytes natural killer : le rejet chronique vasculaire « inné » Open
International audience
View article: IMPact of the COVID-19 epidemic on the moRTAlity of kidney transplant recipients and candidates in a French Nationwide registry sTudy (IMPORTANT)
IMPact of the COVID-19 epidemic on the moRTAlity of kidney transplant recipients and candidates in a French Nationwide registry sTudy (IMPORTANT) Open
View article: Transcriptional Changes in Kidney Allografts with Histology of Antibody-Mediated Rejection without Anti-HLA Donor-Specific Antibodies
Transcriptional Changes in Kidney Allografts with Histology of Antibody-Mediated Rejection without Anti-HLA Donor-Specific Antibodies Open
Significance Statement Donor-specific anti-HLA antibodies (HLA-DSAs) are often not detectable in serum of kidney allograft recipients whose biopsies display histology of antibody-mediated rejection (ABMR), which creates uncertainty in clin…
View article: Prognostic value for long-term graft survival of estimated glomerular filtration rate and proteinuria quantified at 3 months after kidney transplantation
Prognostic value for long-term graft survival of estimated glomerular filtration rate and proteinuria quantified at 3 months after kidney transplantation Open
Background The estimated glomerular filtration rate (eGFR) measured at 1 year is the usual benchmark applied in kidney transplantation (KT). However, acting on earlier eGFR values could help in managing KT during the first post-operative y…
View article: Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants Open
View article: Highly Variable Sialylation Status of Donor-Specific Antibodies Does Not Impact Humoral Rejection Outcomes
Highly Variable Sialylation Status of Donor-Specific Antibodies Does Not Impact Humoral Rejection Outcomes Open
Clinical outcome in antibody-mediated rejection (AMR) shows high inter-individual heterogeneity. Sialylation status of the Fc fragment of IgGs is variable, which could modulate their ability to bind to C1q and/or Fc receptors. In this tran…
View article: Dynamic predictions of long-term kidney graft failure: an information tool promoting patient-centred care
Dynamic predictions of long-term kidney graft failure: an information tool promoting patient-centred care Open
Background Informing kidney transplant recipients of their prognosis and disease progression is of primary importance in a patient-centred vision of care. By participating in decisions from the outset, transplant recipients may be more adh…
View article: Residual Activatability of Circulating Tfh17 Predicts Humoral Response to Thymodependent Antigens in Patients on Therapeutic Immunosuppression
Residual Activatability of Circulating Tfh17 Predicts Humoral Response to Thymodependent Antigens in Patients on Therapeutic Immunosuppression Open
The generation of antibodies against protein antigens (such as donor-specific HLA molecules) requires that T follicular helper cells (Tfh) provide help to B cells. Immunosuppressive (IS) armamentarium prevents T cell activation, yet a sign…
View article: Natural killer cell infiltration is discriminative for antibody-mediated rejection and predicts outcome after kidney transplantation
Natural killer cell infiltration is discriminative for antibody-mediated rejection and predicts outcome after kidney transplantation Open
View article: Rôle de l’activation des cellules « Natural Killer » par le « missing self » dans la génération de lésions de rejet vasculaire chronique après transplantation d’organe
Rôle de l’activation des cellules « Natural Killer » par le « missing self » dans la génération de lésions de rejet vasculaire chronique après transplantation d’organe Open
Organ transplantation is the best treatment for terminal organ failure. However, long-term outcome of organ transplantation remains limited by inexorable loss of graft function, which the prevalent dogma links to the microvascular inflamma…
View article: CD4+ T Cell Help Is Mandatory for Naive and Memory Donor-Specific Antibody Responses: Impact of Therapeutic Immunosuppression
CD4+ T Cell Help Is Mandatory for Naive and Memory Donor-Specific Antibody Responses: Impact of Therapeutic Immunosuppression Open
Antibody-mediated rejection is currently the leading cause of transplant failure. Prevailing dogma predicts that B cells differentiate into anti-donor-specific antibody (DSA)-producing plasma cells only with the help of CD4+ T cells. Yet, …
View article: Endothelial chimerism and vascular sequestration protect pancreatic islet grafts from antibody-mediated rejection
Endothelial chimerism and vascular sequestration protect pancreatic islet grafts from antibody-mediated rejection Open
Humoral rejection is the most common cause of solid organ transplant failure. Here, we evaluated a cohort of 49 patients who were successfully grafted with allogenic islets and determined that the appearance of donor-specific anti-HLA anti…