Alice Kwon
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View article: Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation
Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation Open
Soluble HIV-1 envelope (Env) trimers may serve as effective vaccine immunogens. The widely utilized SOSIP trimers have been paramount for structural studies, but the disulfide bond they feature between gp120 and gp41 constrains intersubuni…
View article: Generalization of the Thistlethwaite--Tsvietkova Method
Generalization of the Thistlethwaite--Tsvietkova Method Open
Thurston's equations determine the hyperbolic structure of a 3-manifold with a triangulation. In work by Thistlethwaite and Tsvietkova, an alternative method was developed for link complements in $S^3$ depending on the link diagram, where …
View article: The Y-Product
The Y-Product Open
We present a topological construction that provides many examples of non-commutative Frobenius algebras that generalizes the well-known pair-of-pants. When applied to the solid torus, in conjunction with Crane-Yetter theory, we provide a t…
View article: Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State
Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State Open
Elucidating the structure and function of the HIV-1 outer envelope proteins is critical for the design of an effective vaccine. Despite the availability of many high-resolution structures, key functional correlates in the envelope trimer r…
View article: Hyperbolicity of Augmented Links in the Thickened Torus
Hyperbolicity of Augmented Links in the Thickened Torus Open
For a hyperbolic link K in the thickened torus with no bigons, we show that there is a decomposition of the complement of a link L, obtained from augmenting K, into torihedra. We further decompose the torihedra into angled pyramids and fin…
View article: Complément to the Thurston 3D-Geometrization
Complément to the Thurston 3D-Geometrization Open
Geometrization says `` any closed oriented three-manifold which is prime (not a connected sum) carries one of the eight Thurston geometries OR it has incompressible torus walls whose complementary components each carry one of four particul…
View article: Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation
Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation Open
The extraordinary ability of human immunodeficiency virus type 1 (HIV-1) to evade host immunity represents a major obstacle to the development of a protective vaccine. Thus, elucidating the mechanisms whereby HIV-1 protects its external en…
View article: Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing
Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing Open
Anti–integrin α4β7 therapy might directly interfere with the ability of HIV to home to intestinal reserviors.